SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3feg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		4 / 6 CYH A 239
ASP A 276
VAL A 237
GLY A 274
 None
 1.25A 1ekjC-3fegA:
undetectable
1ekjD-3fegA:
undetectable		 1ekjC-3fegA:
21.20
1ekjD-3fegA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		4 / 6 CYH A 239
ASP A 276
VAL A 237
GLY A 274
 None
 1.22A 1ekjC-3fegA:
undetectable
1ekjD-3fegA:
undetectable		 1ekjC-3fegA:
21.20
1ekjD-3fegA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		5 / 8 HIS A 240
ASP A 276
SER A 269
THR A 191
ASP A 242
 None
None
None
None
HC7  A   1 (-2.8A)
 1.35A 1p7lC-3fegA:
undetectable		 1p7lC-3fegA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		5 / 8 HIS A 240
ASP A 276
SER A 269
THR A 191
ASP A 242
 None
None
None
None
HC7  A   1 (-2.8A)
 1.34A 1p7lD-3fegA:
undetectable		 1p7lD-3fegA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		5 / 8 HIS A 240
ASP A 276
SER A 269
THR A 191
ASP A 242
 None
None
None
None
HC7  A   1 (-2.8A)
 1.33A 1rg9A-3fegA:
undetectable		 1rg9A-3fegA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		5 / 8 HIS A 240
ASP A 276
SER A 269
THR A 191
ASP A 242
 None
None
None
None
HC7  A   1 (-2.8A)
 1.33A 1rg9B-3fegA:
undetectable		 1rg9B-3fegA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		5 / 8 HIS A 240
ASP A 276
SER A 269
THR A 191
ASP A 242
 None
None
None
None
HC7  A   1 (-2.8A)
 1.33A 1rg9C-3fegA:
undetectable		 1rg9C-3fegA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		5 / 8 HIS A 240
ASP A 276
SER A 269
THR A 191
ASP A 242
 None
None
None
None
HC7  A   1 (-2.8A)
 1.33A 1rg9D-3fegA:
undetectable		 1rg9D-3fegA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		4 / 7 LEU A 126
ASN A 247
ILE A 243
ASP A 242
 None
MG  A 399 ( 2.7A)
None
HC7  A   1 (-2.8A)
 0.84A 1yc2E-3fegA:
undetectable		 1yc2E-3fegA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		5 / 12 ALA A 346
SER A 343
ALA A 348
GLY A 274
GLY A 278
 None
 1.16A 2igtA-3fegA:
undetectable		 2igtA-3fegA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		3 / 3 ARG A 151
GLU A 283
SER A 150
 None
UNX  A 400 ( 3.2A)
AMP  A 398 ( 4.0A)
 0.93A 2xkkA-3fegA:
2.1
2xkkC-3fegA:
2.1		 2xkkA-3fegA:
18.89
2xkkC-3fegA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		4 / 7 LEU A  82
SER A 150
GLY A 132
MET A 261
 AMP  A 398 ( 4.7A)
AMP  A 398 ( 4.0A)
None
None
 1.04A 3hcnA-3fegA:
undetectable		 3hcnA-3fegA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_A_DMEA427_1
(CHOLINE KINASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		8 / 10 ASP A 242
GLN A 244
GLU A 283
TYR A 288
TRP A 353
TRP A 356
PHE A 368
TYR A 373
 HC7  A   1 (-2.8A)
HC7  A   1 (-4.2A)
UNX  A 400 ( 3.2A)
HC7  A   1 ( 3.7A)
HC7  A   1 (-3.9A)
HC7  A   1 (-4.4A)
HC7  A   1 (-3.2A)
HC7  A   1 (-4.0A)
 0.59A 3mesA-3fegA:
35.0		 3mesA-3fegA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_B_DMEB427_1
(CHOLINE KINASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		8 / 10 ASP A 242
GLN A 244
GLU A 283
TYR A 288
TRP A 353
TRP A 356
PHE A 368
TYR A 373
 HC7  A   1 (-2.8A)
HC7  A   1 (-4.2A)
UNX  A 400 ( 3.2A)
HC7  A   1 ( 3.7A)
HC7  A   1 (-3.9A)
HC7  A   1 (-4.4A)
HC7  A   1 (-3.2A)
HC7  A   1 (-4.0A)
 0.61A 3mesB-3fegA:
35.0		 3mesB-3fegA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		6 / 12 LEU A 260
LEU A 262
ILE A 167
MET A 171
GLY A 246
LEU A 153
 None
 1.43A 4lmnA-3fegA:
6.3		 4lmnA-3fegA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens) 		4 / 5 SER A  93
VAL A  94
GLY A  59
ALA A  60
 None
 0.84A 5k50A-3fegA:
undetectable		 5k50A-3fegA:
21.48