SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3feh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3feh CENTAURIN-ALPHA-1
(Homo
sapiens) 		4 / 8 CYH A  44
ASP A  23
CYH A  21
GLY A  25
 ZN  A 375 (-2.3A)
None
ZN  A 375 (-2.3A)
None
 0.99A 1ekjA-3fehA:
undetectable
1ekjB-3fehA:
undetectable		 1ekjA-3fehA:
22.43
1ekjB-3fehA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3feh CENTAURIN-ALPHA-1
(Homo
sapiens) 		3 / 3 ARG A 226
GLU A 178
SER A  91
 None
 0.95A 2xkkA-3fehA:
undetectable
2xkkC-3fehA:
undetectable		 2xkkA-3fehA:
17.84
2xkkC-3fehA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3feh CENTAURIN-ALPHA-1
(Homo
sapiens) 		5 / 10 CYH A  44
ASP A  23
CYH A  21
GLY A  25
ALA A  26
 ZN  A 375 (-2.3A)
None
ZN  A 375 (-2.3A)
None
ZN  A 375 ( 4.7A)
 1.17A 3ucjA-3fehA:
undetectable		 3ucjA-3fehA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3feh CENTAURIN-ALPHA-1
(Homo
sapiens) 		5 / 10 CYH A  44
ASP A  23
CYH A  21
GLY A  25
ALA A  26
 ZN  A 375 (-2.3A)
None
ZN  A 375 (-2.3A)
None
ZN  A 375 ( 4.7A)
 1.14A 3ucjB-3fehA:
undetectable		 3ucjB-3fehA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3feh CENTAURIN-ALPHA-1
(Homo
sapiens) 		4 / 6 LEU A 103
ASP A 220
VAL A 197
ALA A 182
 None
 0.87A 4nkxA-3fehA:
undetectable		 4nkxA-3fehA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3feh CENTAURIN-ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 153
ALA A 159
LEU A 180
THR A 205
ALA A 173
 None
 1.00A 4x1kA-3fehA:
undetectable
4x1kB-3fehA:
undetectable		 4x1kA-3fehA:
22.52
4x1kB-3fehA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 3feh CENTAURIN-ALPHA-1
(Homo
sapiens) 		3 / 3 GLY A  77
ASN A  18
ARG A  82
 None
 0.78A 5w7bD-3fehA:
undetectable		 5w7bD-3fehA:
12.39