SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fes'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3fes ATP-DEPENDENT CLP
ENDOPEPTIDASE
(Clostridioides
difficile) 		5 / 12 ALA A  94
PHE A   5
ILE A  33
LEU A  37
THR A  99
 None
 1.14A 2w3mA-3fesA:
undetectable		 2w3mA-3fesA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3fes ATP-DEPENDENT CLP
ENDOPEPTIDASE
(Clostridioides
difficile) 		4 / 4 LEU A 136
ALA A 110
PHE A  93
ASN A 120
 None
 1.45A 3vasA-3fesA:
undetectable		 3vasA-3fesA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3fes ATP-DEPENDENT CLP
ENDOPEPTIDASE
(Clostridioides
difficile) 		4 / 7 ILE A  86
ARG A  82
ILE A 111
ALA A 119
 None
 0.88A 4lv9A-3fesA:
undetectable		 4lv9A-3fesA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 3fes ATP-DEPENDENT CLP
ENDOPEPTIDASE
(Clostridioides
difficile) 		5 / 11 VAL A  28
GLY A  29
GLU A  31
ALA A  16
SER A  83
 None
 1.16A 5x6yA-3fesA:
undetectable		 5x6yA-3fesA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 3fes ATP-DEPENDENT CLP
ENDOPEPTIDASE
(Clostridioides
difficile) 		5 / 10 VAL A  28
GLY A  29
GLU A  31
ALA A  16
SER A  83
 None
 1.12A 5x6yB-3fesA:
undetectable		 5x6yB-3fesA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3fes ATP-DEPENDENT CLP
ENDOPEPTIDASE
(Clostridioides
difficile) 		3 / 3 ARG A  82
ILE A  86
SER A  30
 None
 0.84A 5zw2A-3fesA:
undetectable		 5zw2A-3fesA:
19.59