SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fet'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 PHE A  12
ASN A  11
ILE A 136
GLY A 134
 None
 1.01A 1oniA-3fetA:
undetectable
1oniB-3fetA:
undetectable		 1oniA-3fetA:
23.84
1oniB-3fetA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ILE A  72
THR A   5
VAL A  77
THR A  75
PHE A  12
 None
 1.48A 1tw4B-3fetA:
undetectable		 1tw4B-3fetA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 LEU A 100
ALA A  71
LEU A  19
THR A   5
 None
 1.13A 1tyrA-3fetA:
undetectable		 1tyrA-3fetA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 TYR A  45
TYR A  67
GLU A 146
 None
 0.80A 3pfgA-3fetA:
undetectable		 3pfgA-3fetA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 LEU A 100
ALA A  71
LEU A  19
THR A   5
 None
 1.14A 4d7bB-3fetA:
undetectable		 4d7bB-3fetA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 GLY A  83
ILE A  72
THR A 130
THR A  93
 None
 0.86A 4em2A-3fetA:
undetectable		 4em2A-3fetA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 LEU A 100
ALA A  71
LEU A  19
THR A   5
 None
 1.04A 4ikkA-3fetA:
undetectable
4ikkB-3fetA:
undetectable		 4ikkA-3fetA:
22.73
4ikkB-3fetA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 LEU A 150
VAL A  43
ASP A  27
 None
 0.56A 4y8wC-3fetA:
undetectable		 4y8wC-3fetA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 LEU A 100
ALA A  71
LEU A  19
THR A   5
 None
 1.13A 5l4iB-3fetA:
undetectable		 5l4iB-3fetA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 ILE A  30
ILE A  81
GLY A  78
LEU A 150
VAL A  56
 None
 0.89A 5twjD-3fetA:
undetectable		 5twjD-3fetA:
22.35