SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3few'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3few COLICIN S4
(Escherichia
coli) 		5 / 12 GLY X 104
GLY X  92
TYR X  91
ILE X 107
LEU X 228
 None
 1.10A 1p91B-3fewX:
undetectable		 1p91B-3fewX:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3few COLICIN S4
(Escherichia
coli) 		5 / 12 VAL X 405
VAL X 444
VAL X 306
GLY X 394
LEU X 458
 None
 1.17A 2cbrA-3fewX:
undetectable		 2cbrA-3fewX:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3few COLICIN S4
(Escherichia
coli) 		4 / 6 ALA X 475
TYR X 329
ILE X 317
ILE X 336
 None
 1.27A 2dcfA-3fewX:
undetectable		 2dcfA-3fewX:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 3few COLICIN S4
(Escherichia
coli) 		4 / 7 ARG X 280
ASN X 274
THR X 240
GLY X 241
 None
 1.05A 2f6dA-3fewX:
undetectable		 2f6dA-3fewX:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 3few COLICIN S4
(Escherichia
coli) 		4 / 6 TYR X 456
LEU X 474
LYS X 320
ASP X 323
 None
 1.46A 2w98A-3fewX:
undetectable
2w98B-3fewX:
undetectable		 2w98A-3fewX:
20.45
2w98B-3fewX:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 3few COLICIN S4
(Escherichia
coli) 		5 / 12 TYR X 231
ASP X 305
ILE X 302
TYR X 293
PHE X 292
 None
 1.45A 3a8iA-3fewX:
0.0		 3a8iA-3fewX:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 3few COLICIN S4
(Escherichia
coli) 		5 / 12 TYR X 231
ASP X 305
ILE X 302
TYR X 293
PHE X 292
 None
 1.43A 3a8iD-3fewX:
undetectable		 3a8iD-3fewX:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3few COLICIN S4
(Escherichia
coli) 		5 / 9 LEU X 453
VAL X 313
ILE X 314
ILE X 317
GLY X 479
 None
 0.91A 4kukA-3fewX:
undetectable		 4kukA-3fewX:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3few COLICIN S4
(Escherichia
coli) 		5 / 12 LEU X 474
VAL X 477
LEU X 482
VAL X 340
GLY X 447
 None
 1.15A 5i8fA-3fewX:
undetectable		 5i8fA-3fewX:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3few COLICIN S4
(Escherichia
coli) 		3 / 3 GLY X 479
VAL X 432
MET X 429
 None
 0.56A 5ycpA-3fewX:
undetectable		 5ycpA-3fewX:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3few COLICIN S4
(Escherichia
coli) 		5 / 12 PHE X 486
LEU X 473
GLY X 471
VAL X 340
ILE X 314
 None
 1.27A 6bxnB-3fewX:
undetectable		 6bxnB-3fewX:
21.76