SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ff6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		3 / 3 TRP A2078
HIS A1993
MET A2075
 None
 1.07A 1l5qB-3ff6A:
3.8		 1l5qB-3ff6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 5 ASP A1807
GLY A1832
ALA A1915
ILE A1914
 None
 0.88A 2aofA-3ff6A:
undetectable		 2aofA-3ff6A:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 7 GLY A2002
PHE A1724
ILE A1825
PHE A1777
 None
 0.94A 2qmzA-3ff6A:
undetectable
2qmzB-3ff6A:
2.5		 2qmzA-3ff6A:
15.27
2qmzB-3ff6A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		3 / 3 LEU A1743
ARG A1776
ILE A1742
 None
 0.62A 2xn5B-3ff6A:
undetectable		 2xn5B-3ff6A:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 8 GLY A1803
ILE A1717
VAL A1749
SER A1801
 None
 0.77A 2yoeB-3ff6A:
2.4
2yoeC-3ff6A:
2.3		 2yoeB-3ff6A:
16.06
2yoeC-3ff6A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		3 / 3 SER A2063
GLN A2062
PHE A2036
 None
 0.75A 3g4lC-3ff6A:
undetectable		 3g4lC-3ff6A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 12 SER A1929
ALA A1940
ILE A1936
LEU A1959
LEU A1945
 None
 1.36A 3lcvB-3ff6A:
undetectable		 3lcvB-3ff6A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 9 ALA A2209
ASP A2208
ILE A2193
ILE A2313
THR A2210
 None
 1.12A 3tq8A-3ff6A:
undetectable		 3tq8A-3ff6A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 12 TYR A1922
HIS A1993
SER A1992
MET A1986
SER A1918
 None
 1.46A 3ugrA-3ff6A:
undetectable		 3ugrA-3ff6A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 4 PRO A2188
LEU A2330
ILE A2092
ARG A2331
 None
 1.37A 3w1wA-3ff6A:
undetectable		 3w1wA-3ff6A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 8 TYR A2192
TYR A2219
ARG A2329
LEU A2330
 None
 1.20A 3wipG-3ff6A:
undetectable
3wipH-3ff6A:
undetectable		 3wipG-3ff6A:
18.04
3wipH-3ff6A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 8 ARG A2329
LEU A2330
TYR A2192
TYR A2219
 None
 1.27A 3wipF-3ff6A:
undetectable
3wipJ-3ff6A:
undetectable		 3wipF-3ff6A:
18.04
3wipJ-3ff6A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 10 LEU A1945
TYR A1810
ASP A1807
GLY A1910
SER A1911
 None
 1.25A 4bwlC-3ff6A:
undetectable		 4bwlC-3ff6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 5 ALA A1828
ILE A1938
LEU A1942
ASN A1830
 None
 1.22A 4g19A-3ff6A:
undetectable		 4g19A-3ff6A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 5 ALA A1935
ILE A1938
LEU A1942
ASN A1830
 None
 0.98A 4g19A-3ff6A:
undetectable		 4g19A-3ff6A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 8 GLU A2198
ASP A2221
ILE A2193
ILE A2313
 None
 0.65A 4kttB-3ff6A:
undetectable		 4kttB-3ff6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 8 GLU A2198
ASP A2221
ILE A2193
ILE A2313
 None
 0.75A 4kttD-3ff6A:
undetectable		 4kttD-3ff6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 12 TYR A2192
GLY A2226
LEU A2317
LEU A2326
ARG A2329
 None
 1.24A 4wcxC-3ff6A:
2.4		 4wcxC-3ff6A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 7 ALA A2197
ASP A2044
ARG A2046
GLU A2073
 None
 0.98A 5btdA-3ff6A:
undetectable
5btdC-3ff6A:
undetectable
5btdD-3ff6A:
undetectable		 5btdA-3ff6A:
22.90
5btdC-3ff6A:
22.90
5btdD-3ff6A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 5 VAL A2083
VAL A2096
GLY A2095
PHE A2071
 None
 1.01A 5d4nA-3ff6A:
undetectable
5d4nC-3ff6A:
undetectable		 5d4nA-3ff6A:
10.20
5d4nC-3ff6A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 11 ILE A1825
ILE A2006
VAL A1790
ASP A1999
ALA A1727
 None
 1.11A 5lg3A-3ff6A:
2.4		 5lg3A-3ff6A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 7 VAL A2339
ARG A2332
GLU A2336
TRP A2384
 None
 1.15A 5umwB-3ff6A:
undetectable
5umwE-3ff6A:
undetectable		 5umwB-3ff6A:
8.23
5umwE-3ff6A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 6 SER A1919
ARG A2146
GLU A1923
TYR A1922
 None
 1.40A 5x7pB-3ff6A:
undetectable		 5x7pB-3ff6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 6 SER A1919
ARG A2146
GLU A1923
TYR A1922
 None
 1.39A 5x7qA-3ff6A:
undetectable		 5x7qA-3ff6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 6 SER A1919
ARG A2146
GLU A1923
TYR A1922
 None
 1.38A 5x7rA-3ff6A:
undetectable		 5x7rA-3ff6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		3 / 3 THR A2084
ALA A2140
LYS A2142
 None
 0.52A 6fgcA-3ff6A:
undetectable		 6fgcA-3ff6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		3 / 3 THR A2084
ALA A2140
LYS A2142
 None
 0.51A 6fgdA-3ff6A:
undetectable		 6fgdA-3ff6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		3 / 3 ARG A1776
PHE A1777
GLY A1785
 None
 0.51A 6fgdA-3ff6A:
undetectable		 6fgdA-3ff6A:
21.24