SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ffh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 7 ILE A 262
PHE A  86
ARG A  70
ALA A  66
 None
 1.12A 1oniD-3ffhA:
undetectable
1oniE-3ffhA:
undetectable		 1oniD-3ffhA:
17.60
1oniE-3ffhA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 6 PHE A  86
ARG A  70
ALA A  66
ILE A 262
 None
 1.22A 1oniH-3ffhA:
undetectable
1oniI-3ffhA:
undetectable		 1oniH-3ffhA:
17.60
1oniI-3ffhA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 7 ILE A 307
LEU A 309
ARG A 328
LEU A 320
 None
None
SO4  A 363 (-2.6A)
None
 1.01A 1v54N-3ffhA:
undetectable
1v54W-3ffhA:
undetectable		 1v54N-3ffhA:
20.95
1v54W-3ffhA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 8 TYR A 233
PHE A  86
ALA A 236
LEU A  79
 None
 1.11A 1x8vA-3ffhA:
undetectable		 1x8vA-3ffhA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 7 ILE A 307
LEU A 309
ARG A 328
LEU A 320
 None
None
SO4  A 363 (-2.6A)
None
 0.98A 2dyrN-3ffhA:
undetectable
2dyrW-3ffhA:
undetectable		 2dyrN-3ffhA:
20.95
2dyrW-3ffhA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 9 LEU A 189
ILE A 194
LEU A 171
ILE A 174
TYR A 168
 None
None
SO4  A 362 (-4.1A)
None
SO4  A 362 (-4.5A)
 1.23A 2f7aB-3ffhA:
undetectable		 2f7aB-3ffhA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 7 ILE A 307
LEU A 309
ARG A 328
LEU A 320
 None
None
SO4  A 363 (-2.6A)
None
 1.03A 3ablA-3ffhA:
undetectable
3ablJ-3ffhA:
undetectable		 3ablA-3ffhA:
20.95
3ablJ-3ffhA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 11 ALA A  48
GLY A 225
GLY A  42
ILE A  50
SER A 228
 None
 0.94A 3dcmX-3ffhA:
undetectable		 3dcmX-3ffhA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 12 ILE A 158
ALA A 111
LEU A 134
PRO A 299
TYR A 118
 None
 1.24A 3eigA-3ffhA:
undetectable		 3eigA-3ffhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		3 / 3 TYR A 325
TYR A 285
ILE A 353
 None
 0.72A 3eteA-3ffhA:
3.8
3eteB-3ffhA:
3.8		 3eteA-3ffhA:
22.33
3eteB-3ffhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 12 LEU A 186
VAL A 181
LEU A 146
ILE A 174
ILE A 216
 None
 1.09A 3ijdA-3ffhA:
undetectable		 3ijdA-3ffhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 12 LEU A 186
VAL A 181
LEU A 146
ILE A 174
ILE A 216
 None
 1.16A 3ijdB-3ffhA:
undetectable		 3ijdB-3ffhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		3 / 3 LYS A 222
ARG A 340
LYS A  17
 SO4  A 361 (-3.5A)
SO4  A 363 (-3.2A)
None
 1.36A 3okxA-3ffhA:
undetectable		 3okxA-3ffhA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 9 TYR A 118
ILE A  94
VAL A  90
THR A 217
ILE A 215
 None
None
SO4  A 361 (-3.5A)
None
None
 1.37A 3p4wA-3ffhA:
undetectable		 3p4wA-3ffhA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 4 LEU A 134
GLY A 138
LEU A 135
GLU A 139
 None
 1.06A 3tgvB-3ffhA:
undetectable		 3tgvB-3ffhA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 7 TYR A 233
VAL A  90
ILE A  94
GLU A 195
 None
SO4  A 361 (-3.5A)
None
None
 1.13A 4a97H-3ffhA:
undetectable		 4a97H-3ffhA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 8 TYR A 233
VAL A  90
ILE A  94
GLU A 195
 None
SO4  A 361 (-3.5A)
None
None
 1.08A 4a97I-3ffhA:
undetectable		 4a97I-3ffhA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 12 LEU A 189
GLU A 191
ILE A 240
ILE A 241
LEU A  93
 None
 1.23A 4j24C-3ffhA:
undetectable		 4j24C-3ffhA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 12 LEU A 189
GLU A 191
ILE A 240
ILE A 241
LEU A  93
 None
 1.22A 4j26B-3ffhA:
undetectable		 4j26B-3ffhA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 12 GLU A 273
ALA A 264
ASN A  39
GLY A 225
LEU A 226
 None
 1.09A 4oaeA-3ffhA:
undetectable		 4oaeA-3ffhA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 6 TYR A 233
GLU A 195
TYR A 224
LEU A 226
 None
 1.35A 4twdF-3ffhA:
undetectable
4twdG-3ffhA:
undetectable		 4twdF-3ffhA:
23.29
4twdG-3ffhA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 12 PRO A 299
GLY A 302
GLY A 166
ILE A 194
ASN A 160
 None
 1.10A 5fa8A-3ffhA:
undetectable		 5fa8A-3ffhA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 7 ILE A 307
LEU A 309
ARG A 328
LEU A 320
 None
None
SO4  A 363 (-2.6A)
None
 0.99A 5iy5A-3ffhA:
undetectable
5iy5J-3ffhA:
undetectable		 5iy5A-3ffhA:
20.95
5iy5J-3ffhA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 10 TYR A 118
ILE A  94
VAL A  90
THR A 217
ILE A 215
 None
None
SO4  A 361 (-3.5A)
None
None
 1.36A 5mzrA-3ffhA:
undetectable		 5mzrA-3ffhA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 10 TYR A 118
ILE A  94
VAL A  90
THR A 217
ILE A 215
 None
None
SO4  A 361 (-3.5A)
None
None
 1.34A 5mzrC-3ffhA:
undetectable		 5mzrC-3ffhA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		5 / 9 TYR A 118
ILE A  94
VAL A  90
THR A 217
ILE A 215
 None
None
SO4  A 361 (-3.5A)
None
None
 1.36A 5mzrD-3ffhA:
undetectable		 5mzrD-3ffhA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 6 VAL A 188
LEU A 101
THR A  98
TRP A 157
 None
 0.81A 5ogjA-3ffhA:
undetectable		 5ogjA-3ffhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 6 VAL A 188
LEU A 101
THR A  98
TRP A 157
 None
 0.80A 5ogjB-3ffhA:
undetectable		 5ogjB-3ffhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 6 VAL A 188
LEU A 101
THR A  98
TRP A 157
 None
 0.81A 5ohhB-3ffhA:
undetectable		 5ohhB-3ffhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 7 PHE A  76
LEU A  69
ILE A 271
ALA A 229
 None
 0.87A 6b5vA-3ffhA:
undetectable
6b5vC-3ffhA:
undetectable		 6b5vA-3ffhA:
12.50
6b5vC-3ffhA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 7 ALA A 229
PHE A  76
LEU A  69
ILE A 271
 None
 0.85A 6b5vA-3ffhA:
undetectable
6b5vB-3ffhA:
undetectable		 6b5vA-3ffhA:
12.50
6b5vB-3ffhA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 7 PHE A  76
LEU A  69
ILE A 271
ALA A 229
 None
 0.88A 6b5vC-3ffhA:
undetectable
6b5vD-3ffhA:
undetectable		 6b5vC-3ffhA:
12.50
6b5vD-3ffhA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Listeria
innocua) 		4 / 7 ALA A 229
PHE A  76
LEU A  69
ILE A 271
 None
 0.87A 6b5vB-3ffhA:
undetectable
6b5vD-3ffhA:
undetectable		 6b5vB-3ffhA:
12.50
6b5vD-3ffhA:
12.50