SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fg4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 TYR A1054
HIS A 752
PRO A 593
VAL A 997
 None
None
None
ACY  A2203 (-4.5A)
 1.43A 1q13A-3fg4A:
undetectable		 1q13A-3fg4A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 10 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
 None
 1.47A 1qkuA-3fg4A:
undetectable		 1qkuA-3fg4A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 10 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
 None
 1.47A 1qkuB-3fg4A:
undetectable		 1qkuB-3fg4A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 10 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
 None
 1.47A 1qkuC-3fg4A:
undetectable		 1qkuC-3fg4A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 HIS A 762
HIS A 757
HIS A 943
 FE2  A1500 (-3.2A)
FE2  A1500 (-3.3A)
FE2  A1500 (-3.2A)
 0.66A 1rkyA-3fg4A:
undetectable		 1rkyA-3fg4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.81A 1v54N-3fg4A:
undetectable
1v54W-3fg4A:
undetectable		 1v54N-3fg4A:
20.56
1v54W-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.85A 1v55A-3fg4A:
1.9
1v55J-3fg4A:
undetectable		 1v55A-3fg4A:
20.56
1v55J-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.84A 1v55N-3fg4A:
undetectable
1v55W-3fg4A:
undetectable		 1v55N-3fg4A:
20.56
1v55W-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 HIS A 762
HIS A 757
HIS A 943
 FE2  A1500 (-3.2A)
FE2  A1500 (-3.3A)
FE2  A1500 (-3.2A)
 0.71A 1w2zD-3fg4A:
undetectable		 1w2zD-3fg4A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.84A 2dyrN-3fg4A:
undetectable
2dyrW-3fg4A:
undetectable		 2dyrN-3fg4A:
20.56
2dyrW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.83A 2eijN-3fg4A:
1.7
2eijW-3fg4A:
undetectable		 2eijN-3fg4A:
20.56
2eijW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.85A 2eikN-3fg4A:
1.9
2eikW-3fg4A:
undetectable		 2eikN-3fg4A:
20.56
2eikW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.85A 2eilN-3fg4A:
1.9
2eilW-3fg4A:
undetectable		 2eilN-3fg4A:
20.56
2eilW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.80A 2einA-3fg4A:
2.0
2einJ-3fg4A:
undetectable		 2einA-3fg4A:
20.56
2einJ-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.85A 2einN-3fg4A:
undetectable
2einW-3fg4A:
undetectable		 2einN-3fg4A:
20.56
2einW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 11 LEU A 776
LEU A 786
ILE A 899
PRO A 919
LEU A 492
 None
 1.36A 2ft9A-3fg4A:
0.1		 2ft9A-3fg4A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 THR A 765
ALA A 945
TYR A 860
PHE A 937
 None
 0.99A 2hzqA-3fg4A:
undetectable		 2hzqA-3fg4A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 HIS A 762
HIS A 757
HIS A 943
 FE2  A1500 (-3.2A)
FE2  A1500 (-3.3A)
FE2  A1500 (-3.2A)
 0.73A 2oqeC-3fg4A:
undetectable		 2oqeC-3fg4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 HIS A 762
HIS A 757
HIS A 943
 FE2  A1500 (-3.2A)
FE2  A1500 (-3.3A)
FE2  A1500 (-3.2A)
 0.72A 2oqeD-3fg4A:
undetectable		 2oqeD-3fg4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 PRO A1051
ASN A1045
ARG A1044
 None
None
GOL  A2306 ( 4.3A)
 1.01A 2qeuB-3fg4A:
undetectable		 2qeuB-3fg4A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
VAL A 433
GLY A 434
ARG A 469
 None
 0.73A 2wd9A-3fg4A:
undetectable		 2wd9A-3fg4A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
VAL A 433
GLY A 434
ARG A 469
 None
 0.71A 2wd9B-3fg4A:
undetectable		 2wd9B-3fg4A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.77A 3abkA-3fg4A:
2.7
3abkJ-3fg4A:
undetectable		 3abkA-3fg4A:
20.56
3abkJ-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.88A 3ablN-3fg4A:
1.7
3ablW-3fg4A:
undetectable		 3ablN-3fg4A:
20.56
3ablW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.86A 3abmN-3fg4A:
undetectable
3abmW-3fg4A:
undetectable		 3abmN-3fg4A:
20.56
3abmW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.97A 3ag1N-3fg4A:
undetectable
3ag1W-3fg4A:
undetectable		 3ag1N-3fg4A:
20.56
3ag1W-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.78A 3ag3A-3fg4A:
1.8
3ag3J-3fg4A:
undetectable		 3ag3A-3fg4A:
20.56
3ag3J-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ASN A 636
SER A 638
ALA A 637
HIS A 730
 GOL  A2301 ( 3.0A)
None
None
None
 1.17A 3aruA-3fg4A:
3.2		 3aruA-3fg4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.84A 3asnN-3fg4A:
1.7
3asnW-3fg4A:
undetectable		 3asnN-3fg4A:
20.56
3asnW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.81A 3asoN-3fg4A:
undetectable
3asoW-3fg4A:
undetectable		 3asoN-3fg4A:
20.56
3asoW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 THR A 765
SER A 934
LEU A 935
THR A 938
 None
 0.82A 3deuB-3fg4A:
undetectable		 3deuB-3fg4A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 HIS A 762
HIS A 757
HIS A 943
 FE2  A1500 (-3.2A)
FE2  A1500 (-3.3A)
FE2  A1500 (-3.2A)
 0.73A 3hiiA-3fg4A:
undetectable		 3hiiA-3fg4A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 HIS A 762
HIS A 757
HIS A 943
 FE2  A1500 (-3.2A)
FE2  A1500 (-3.3A)
FE2  A1500 (-3.2A)
 0.72A 3hiiB-3fg4A:
undetectable		 3hiiB-3fg4A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ASN A 947
HIS A 943
LEU A 758
ASP A 797
 FE2  A1500 (-3.7A)
FE2  A1500 (-3.2A)
None
ACD  A2001 ( 4.5A)
 1.11A 3oi8A-3fg4A:
undetectable		 3oi8A-3fg4A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 5 ARG A 861
LEU A 844
PRO A 615
ASP A 862
 None
 1.08A 3ufnA-3fg4A:
undetectable
3ufnB-3fg4A:
undetectable		 3ufnA-3fg4A:
9.39
3ufnB-3fg4A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.94A 3wg7N-3fg4A:
undetectable
3wg7W-3fg4A:
undetectable		 3wg7N-3fg4A:
20.56
3wg7W-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 LEU A 935
LEU A 932
LEU A 928
ILE A 899
GLN A 896
 None
 0.79A 4a7aB-3fg4A:
undetectable		 4a7aB-3fg4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 ILE A 649
LEU A 645
VAL A 635
LEU A 624
ILE A 726
 None
 1.14A 4g1bD-3fg4A:
2.2		 4g1bD-3fg4A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 10 LEU A 776
LEU A 786
ILE A 895
VAL A 902
TRP A 907
 None
 1.35A 4mk4A-3fg4A:
undetectable		 4mk4A-3fg4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 8 GLY A 612
GLN A 608
TYR A 954
SER A 949
SER A 749
 None
ACY  A2201 (-3.6A)
ACY  A2203 (-3.5A)
None
None
 1.30A 4wryA-3fg4A:
undetectable		 4wryA-3fg4A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 8 GLY A 612
GLN A 608
TYR A 954
SER A 949
SER A 749
 None
ACY  A2201 (-3.6A)
ACY  A2203 (-3.5A)
None
None
 1.32A 4wrzA-3fg4A:
undetectable		 4wrzA-3fg4A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 ASP A 391
GLY A 446
ASP A 444
 None
 0.58A 4xdtA-3fg4A:
undetectable		 4xdtA-3fg4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 TYR A 678
ALA A 695
ASN A 717
ILE A 716
 None
 0.68A 4y03A-3fg4A:
undetectable		 4y03A-3fg4A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 LYS A1002
ILE A1066
ILE A 796
 None
None
ACD  A2001 ( 4.9A)
 0.59A 4y0qA-3fg4A:
undetectable		 4y0qA-3fg4A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 LEU A 492
ASP A 892
LEU A 776
ILE A 878
 None
 1.13A 4y4dA-3fg4A:
undetectable		 4y4dA-3fg4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 5 ALA A 531
ARG A 801
ALA A 795
GLU A 766
 None
 1.35A 5a06C-3fg4A:
undetectable
5a06D-3fg4A:
undetectable		 5a06C-3fg4A:
18.95
5a06D-3fg4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.84A 5b1bA-3fg4A:
undetectable
5b1bJ-3fg4A:
undetectable		 5b1bA-3fg4A:
20.56
5b1bJ-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.80A 5b3sN-3fg4A:
1.7
5b3sW-3fg4A:
undetectable		 5b3sN-3fg4A:
20.56
5b3sW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 994
ALA A 960
VAL A 997
HIS A 953
 None
ACY  A2201 ( 3.8A)
ACY  A2203 (-4.5A)
ACY  A2201 (-3.9A)
 0.88A 5ecnD-3fg4A:
undetectable		 5ecnD-3fg4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ILE A 879
TYR A 883
PHE A 882
THR A 772
 GOL  A2302 (-3.7A)
None
None
None
 1.12A 5g08A-3fg4A:
undetectable		 5g08A-3fg4A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 PHE A 486
PRO A 498
THR A 399
ILE A 500
 None
 1.42A 5ih0A-3fg4A:
undetectable		 5ih0A-3fg4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.84A 5iy5A-3fg4A:
undetectable
5iy5J-3fg4A:
undetectable		 5iy5A-3fg4A:
20.56
5iy5J-3fg4A:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.88A 5iy5N-3fg4A:
1.8
5iy5W-3fg4A:
undetectable		 5iy5N-3fg4A:
20.56
5iy5W-3fg4A:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 GLN A 753
ASN A 947
HIS A 762
HIS A 757
 ACY  A2203 (-2.6A)
FE2  A1500 (-3.7A)
FE2  A1500 (-3.2A)
FE2  A1500 (-3.3A)
 1.19A 5km8A-3fg4A:
undetectable
5km8B-3fg4A:
undetectable		 5km8A-3fg4A:
12.55
5km8B-3fg4A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 PHE A 494
HIS A 780
PRO A 781
ILE A 782
 None
 0.91A 5vkqA-3fg4A:
undetectable
5vkqD-3fg4A:
3.1		 5vkqA-3fg4A:
17.51
5vkqD-3fg4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 ARG A 861
PHE A 609
LEU A 855
 None
ACY  A2201 (-3.8A)
None
 0.92A 5x1bC-3fg4A:
2.2		 5x1bC-3fg4A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLY A 383
ALA A1015
ASP A 384
GLU A 419
THR A 382
 GOL  A2305 (-3.4A)
GOL  A2305 (-3.6A)
GOL  A2305 (-3.9A)
None
None
 1.35A 5x6yC-3fg4A:
undetectable		 5x6yC-3fg4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.93A 5xdqA-3fg4A:
1.9
5xdqJ-3fg4A:
undetectable		 5xdqA-3fg4A:
20.56
5xdqJ-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.76A 5xdqN-3fg4A:
1.6
5xdqW-3fg4A:
undetectable		 5xdqN-3fg4A:
20.56
5xdqW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.91A 5xdxA-3fg4A:
undetectable
5xdxJ-3fg4A:
undetectable		 5xdxA-3fg4A:
20.56
5xdxJ-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.80A 5xdxN-3fg4A:
undetectable
5xdxW-3fg4A:
undetectable		 5xdxN-3fg4A:
20.56
5xdxW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 SER A 940
HIS A 789
TYR A1013
 None
 0.96A 5y2tA-3fg4A:
undetectable		 5y2tA-3fg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.77A 5z86N-3fg4A:
undetectable
5z86W-3fg4A:
undetectable		 5z86N-3fg4A:
20.56
5z86W-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.79A 5zcoN-3fg4A:
undetectable
5zcoW-3fg4A:
undetectable		 5zcoN-3fg4A:
20.56
5zcoW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.77A 5zcpN-3fg4A:
1.9
5zcpW-3fg4A:
undetectable		 5zcpN-3fg4A:
20.56
5zcpW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.91A 6nmfA-3fg4A:
undetectable
6nmfJ-3fg4A:
undetectable		 6nmfA-3fg4A:
20.56
6nmfJ-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 5 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.84A 6nmpN-3fg4A:
undetectable
6nmpW-3fg4A:
undetectable		 6nmpN-3fg4A:
20.56
6nmpW-3fg4A:
8.30