SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fg7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 3fg7 VILLIN-1
(Homo
sapiens) 		4 / 6 ARG A 689
ASP A 690
THR A 693
ASP A 653
 None
 0.84A 2j2pE-3fg7A:
undetectable
2j2pF-3fg7A:
undetectable		 2j2pE-3fg7A:
19.85
2j2pF-3fg7A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3fg7 VILLIN-1
(Homo
sapiens) 		4 / 8 LYS A 671
GLU A 668
LYS A 699
ILE A 662
 None
 0.90A 2j9dJ-3fg7A:
undetectable
2j9dK-3fg7A:
undetectable
2j9dL-3fg7A:
undetectable		 2j9dJ-3fg7A:
17.22
2j9dK-3fg7A:
17.22
2j9dL-3fg7A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3fg7 VILLIN-1
(Homo
sapiens) 		4 / 8 LYS A 699
ILE A 662
LYS A 671
GLU A 668
 None
 0.93A 2j9dJ-3fg7A:
undetectable
2j9dK-3fg7A:
undetectable
2j9dL-3fg7A:
undetectable		 2j9dJ-3fg7A:
17.22
2j9dK-3fg7A:
17.22
2j9dL-3fg7A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 3fg7 VILLIN-1
(Homo
sapiens) 		3 / 3 THR A 708
PRO A 704
THR A 706
 None
 0.88A 316dC-3fg7A:
undetectable		 316dC-3fg7A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3fg7 VILLIN-1
(Homo
sapiens) 		4 / 8 THR A 693
PRO A 694
ARG A 689
VAL A 658
 None
 1.19A 4qknA-3fg7A:
undetectable		 4qknA-3fg7A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 3fg7 VILLIN-1
(Homo
sapiens) 		4 / 5 PHE A 622
PHE A 650
LEU A 621
LEU A 632
 None
 1.22A 5veuH-3fg7A:
undetectable		 5veuH-3fg7A:
21.67