SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fge'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN
(Shewanella
frigidimarina) 		3 / 3 ARG A 196
GLY A 170
ASP A 169
 None
 0.59A 1kf6A-3fgeA:
undetectable
1kf6B-3fgeA:
undetectable		 1kf6A-3fgeA:
15.36
1kf6B-3fgeA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN
(Shewanella
frigidimarina) 		3 / 3 PHE A 109
TYR A 118
PRO A 116
 None
 1.17A 1mcnA-3fgeA:
undetectable
1mcnB-3fgeA:
undetectable
1mcnP-3fgeA:
undetectable		 1mcnA-3fgeA:
21.37
1mcnB-3fgeA:
21.37
1mcnP-3fgeA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN
(Shewanella
frigidimarina) 		4 / 5 GLN A  35
THR A  41
GLU A 108
THR A  98
 None
 1.50A 3glqA-3fgeA:
undetectable		 3glqA-3fgeA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN
(Shewanella
frigidimarina) 		4 / 6 SER A 107
THR A  72
THR A 112
PHE A 109
 None
 1.00A 4acbC-3fgeA:
undetectable		 4acbC-3fgeA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN
(Shewanella
frigidimarina) 		3 / 3 GLY A 184
LEU A 185
HIS A  18
 None
 0.68A 5u63A-3fgeA:
undetectable		 5u63A-3fgeA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN
(Shewanella
frigidimarina) 		5 / 12 LEU A  58
ILE A  50
SER A  28
PHE A 151
VAL A 139
 None
 1.18A 5uanB-3fgeA:
undetectable		 5uanB-3fgeA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN
(Shewanella
frigidimarina) 		4 / 8 ILE A  84
THR A  83
THR A  72
GLU A 108
 None
 1.10A 6c06C-3fgeA:
undetectable		 6c06C-3fgeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN
(Shewanella
frigidimarina) 		5 / 11 TYR A 118
THR A  41
GLU A 110
PHE A 109
LEU A 119
 None
 1.40A 6efnA-3fgeA:
undetectable		 6efnA-3fgeA:
20.78