SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 3fgq NEUROSERPIN
(Homo
sapiens) 		5 / 12 LEU A 303
ALA A  56
MET A  60
MET A  76
LEU A 333
 None
 1.34A 1brpA-3fgqA:
undetectable		 1brpA-3fgqA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3fgq NEUROSERPIN
(Homo
sapiens) 		4 / 8 TYR A 104
PHE A 186
MET A 106
THR A 387
 None
 1.17A 1ea1A-3fgqA:
undetectable		 1ea1A-3fgqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 3fgq NEUROSERPIN
(Homo
sapiens) 		4 / 6 LEU A  55
LEU A  62
LEU A 112
LEU A  81
 None
 0.91A 1errA-3fgqA:
undetectable		 1errA-3fgqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3fgq NEUROSERPIN
(Homo
sapiens) 		5 / 12 ALA A  64
LEU A 322
LEU A 333
ALA A  56
ILE A  72
 None
 1.30A 1g5yB-3fgqA:
undetectable		 1g5yB-3fgqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3fgq NEUROSERPIN
(Homo
sapiens) 		5 / 11 LEU A 303
ALA A  56
MET A  60
MET A  76
LEU A 333
 None
 1.40A 1iiuA-3fgqA:
undetectable		 1iiuA-3fgqA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3fgq NEUROSERPIN
(Homo
sapiens) 		4 / 7 LEU A 180
LEU A  55
LEU A  62
GLY A  63
 None
 0.87A 1n13D-3fgqA:
undetectable
1n13E-3fgqA:
undetectable		 1n13D-3fgqA:
15.62
1n13E-3fgqA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3fgq NEUROSERPIN
(Homo
sapiens) 		4 / 5 LYS A  82
PHE A  89
LEU A  81
MET A  76
 None
 1.47A 1skxA-3fgqA:
undetectable		 1skxA-3fgqA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3fgq NEUROSERPIN
(Homo
sapiens) 		4 / 5 LEU A  29
PRO A  22
ALA A  25
ILE A  26
 None
 0.92A 2aofB-3fgqA:
undetectable		 2aofB-3fgqA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3fgq NEUROSERPIN
(Homo
sapiens) 		4 / 6 VAL A 184
SER A 340
LEU A  51
PHE A  48
 None
 1.32A 2f8dA-3fgqA:
undetectable		 2f8dA-3fgqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3fgq NEUROSERPIN
(Homo
sapiens) 		4 / 8 PHE A 132
LEU A  90
PHE A  87
GLY A  58
 None
 0.91A 2vdbA-3fgqA:
undetectable		 2vdbA-3fgqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3fgq NEUROSERPIN
(Homo
sapiens) 		4 / 7 GLU A 227
VAL A 283
GLN A 286
VAL A 288
 None
 0.90A 3kp6B-3fgqA:
undetectable		 3kp6B-3fgqA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3fgq NEUROSERPIN
(Homo
sapiens) 		4 / 6 ALA A  56
ILE A  53
HIS A 338
VAL A 184
 None
 1.00A 3nneG-3fgqA:
undetectable		 3nneG-3fgqA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3fgq NEUROSERPIN
(Homo
sapiens) 		5 / 9 ARG A 393
GLY A 392
LEU A  47
ASN A  45
ILE A 301
 None
 1.38A 3wdmA-3fgqA:
undetectable		 3wdmA-3fgqA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3fgq NEUROSERPIN
(Homo
sapiens) 		5 / 9 GLY A 392
LEU A  37
LEU A  47
ASN A  45
ILE A 301
 None
 1.38A 3wdmA-3fgqA:
undetectable		 3wdmA-3fgqA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3fgq NEUROSERPIN
(Homo
sapiens) 		5 / 12 GLU A 122
GLY A 324
ALA A  64
LEU A 112
ILE A 315
 None
 1.21A 4hytA-3fgqA:
undetectable		 4hytA-3fgqA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3fgq NEUROSERPIN
(Homo
sapiens) 		5 / 12 LEU A 325
LEU A 125
LEU A 112
ASN A 137
ALA A 134
 None
 1.12A 4x1yB-3fgqA:
undetectable		 4x1yB-3fgqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3fgq NEUROSERPIN
(Homo
sapiens) 		5 / 12 ASP A  79
GLY A  77
MET A  76
LEU A  29
ALA A  54
 None
 1.37A 5kbwA-3fgqA:
undetectable		 5kbwA-3fgqA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 3fgq NEUROSERPIN
(Homo
sapiens) 		4 / 5 SER A 340
VAL A 184
ASN A 182
PRO A  50
 None
 1.30A 6fi4A-3fgqA:
undetectable
6fi4B-3fgqA:
undetectable		 6fi4A-3fgqA:
20.57
6fi4B-3fgqA:
4.04