SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		3 / 3 GLN A 526
HIS A 529
PRO A 524
 None
 0.84A 1d8cA-3fgwA:
undetectable		 1d8cA-3fgwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		5 / 9 LEU A 118
LEU A 205
VAL A 126
GLY A 124
ALA A  90
 NAG  A  11 ( 4.6A)
None
None
None
None
 1.20A 1e7aA-3fgwA:
undetectable		 1e7aA-3fgwA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 8 TRP A 593
SER A  64
ASN A  93
ASP A 594
 None
NAG  A   1 (-2.9A)
NAG  A   1 (-2.1A)
None
 1.10A 1ig3A-3fgwA:
undetectable
1ig3B-3fgwA:
undetectable		 1ig3A-3fgwA:
18.88
1ig3B-3fgwA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 7 ASP A 594
TRP A 593
SER A  64
ASN A  93
 None
None
NAG  A   1 (-2.9A)
NAG  A   1 (-2.1A)
 1.12A 1ig3A-3fgwA:
undetectable
1ig3B-3fgwA:
undetectable		 1ig3A-3fgwA:
18.88
1ig3B-3fgwA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		3 / 3 GLN A 186
HIS A 185
ARG A 287
 None
 1.08A 1zlqA-3fgwA:
undetectable		 1zlqA-3fgwA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		5 / 10 GLU A 350
ASN A 381
GLU A 232
LEU A 235
TYR A 156
 None
 1.40A 2ha6A-3fgwA:
undetectable		 2ha6A-3fgwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		5 / 10 GLU A 350
ASN A 381
GLU A 232
LEU A 235
TYR A 156
 None
 1.42A 2ha6B-3fgwA:
undetectable		 2ha6B-3fgwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 6 ARG A 287
GLU A 288
GLN A 186
PRO A 182
 None
 1.46A 2qqtA-3fgwA:
undetectable		 2qqtA-3fgwA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		3 / 3 TRP A 170
GLN A 343
TRP A 351
 None
 1.06A 2vqyA-3fgwA:
1.4		 2vqyA-3fgwA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		5 / 12 LEU A 197
GLY A 124
PHE A 304
LEU A 302
VAL A  89
 None
 1.33A 2w8yA-3fgwA:
undetectable		 2w8yA-3fgwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		5 / 12 LEU A 284
ASN A 300
LEU A 320
GLY A 321
MET A 549
 None
 1.30A 2yhdA-3fgwA:
undetectable		 2yhdA-3fgwA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 6 ALA A 265
LEU A 263
SER A 542
VAL A 538
 None
 0.92A 3d2tB-3fgwA:
undetectable		 3d2tB-3fgwA:
14.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 4 ARG A 469
ASP A 488
ASP A 492
PRO A 493
 None
 0.43A 3fgrB-3fgwA:
50.2		 3fgrB-3fgwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 6 ARG A 287
GLU A 288
GLN A 186
PRO A 182
 None
 1.47A 3gclA-3fgwA:
undetectable		 3gclA-3fgwA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 6 ARG A 513
SER A 570
ASP A 582
PRO A 564
 None
 1.49A 3jqaC-3fgwA:
undetectable		 3jqaC-3fgwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 6 ARG A 513
SER A 570
ASP A 582
PRO A 564
 None
 1.49A 3jqaD-3fgwA:
undetectable		 3jqaD-3fgwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		3 / 3 LYS A 215
PRO A 216
LEU A 217
 IOD  A  16 (-4.5A)
IOD  A  16 ( 4.2A)
IOD  A  16 (-4.3A)
 0.66A 3tpxE-3fgwA:
undetectable		 3tpxE-3fgwA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 7 TRP A 584
PRO A 581
ASN A  96
ILE A  98
 None
 0.98A 3u5kB-3fgwA:
undetectable		 3u5kB-3fgwA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		3 / 3 ARG A 485
THR A 101
TRP A 103
 None
 1.25A 4d7hA-3fgwA:
undetectable		 4d7hA-3fgwA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 6 GLY A 247
ASN A 508
GLN A 382
MET A 384
 None
 1.24A 4g0vB-3fgwA:
undetectable		 4g0vB-3fgwA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 8 SER A 305
HIS A 266
TYR A 307
GLU A 328
 None
None
None
NA  A 610 (-3.1A)
 1.28A 4ms4A-3fgwA:
undetectable		 4ms4A-3fgwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		5 / 12 ALA A 357
THR A 419
THR A 404
VAL A 402
LEU A 324
 None
 1.35A 4qynA-3fgwA:
undetectable		 4qynA-3fgwA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		5 / 12 ALA A 357
THR A 419
THR A 404
VAL A 402
LEU A 324
 None
 1.29A 4qzuA-3fgwA:
undetectable		 4qzuA-3fgwA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		3 / 3 ARG A 485
THR A 101
TRP A 103
 None
 1.17A 4ug5A-3fgwA:
undetectable		 4ug5A-3fgwA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 6 LEU A  78
ALA A 122
LEU A 205
SER A 200
 IOD  A 609 (-4.1A)
None
None
None
 1.25A 5a6iA-3fgwA:
undetectable		 5a6iA-3fgwA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		5 / 12 GLY A 377
GLN A 408
LEU A 168
GLY A 218
PHE A 163
 None
 1.15A 5fsaB-3fgwA:
undetectable		 5fsaB-3fgwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		3 / 3 ARG A 485
THR A 101
TRP A 103
 None
 1.23A 5g6cA-3fgwA:
undetectable		 5g6cA-3fgwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		5 / 12 ILE A 319
HIS A 266
TYR A 388
ALA A 546
MET A 549
 None
 1.29A 5n0xB-3fgwA:
undetectable		 5n0xB-3fgwA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		3 / 3 THR A 209
PRO A 290
ARG A 287
 NAG  A  12 (-3.6A)
None
None
 0.82A 5nd7B-3fgwA:
undetectable		 5nd7B-3fgwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 8 TRP A 584
TRP A 567
HIS A 138
THR A 142
 None
 1.44A 5yj1G-3fgwA:
undetectable
5yj1Y-3fgwA:
undetectable		 5yj1G-3fgwA:
10.84
5yj1Y-3fgwA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 6 ARG A 485
GLY A 556
THR A 268
TRP A 103
 None
 1.11A 5ysiA-3fgwA:
undetectable		 5ysiA-3fgwA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		5 / 12 VAL A 126
LEU A 302
LEU A 284
ALA A 123
GLY A 309
 None
 1.03A 6b0iB-3fgwA:
undetectable		 6b0iB-3fgwA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		4 / 4 VAL A 342
GLY A 377
ASP A 230
ASP A 227
 None
 1.28A 6cjkC-3fgwA:
undetectable		 6cjkC-3fgwA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2
(Mus
musculus) 		3 / 3 LEU A 552
LEU A 545
ARG A 590
 None
 0.70A 6fgcA-3fgwA:
undetectable		 6fgcA-3fgwA:
21.27