SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fh3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR
(Bacillus
anthracis) 		5 / 11 LEU A  89
PHE A 147
MET A 154
TYR A 114
GLN A  90
 None
 1.25A 1hbpA-3fh3A:
undetectable		 1hbpA-3fh3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR
(Bacillus
anthracis) 		3 / 3 SER A 130
GLU A 151
ASP A 158
 None
 0.71A 2zulA-3fh3A:
undetectable		 2zulA-3fh3A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR
(Bacillus
anthracis) 		3 / 3 SER A 130
GLU A 151
ASP A 158
 None
 0.68A 3dmhA-3fh3A:
undetectable		 3dmhA-3fh3A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR
(Bacillus
anthracis) 		3 / 3 LYS A  59
LEU A  55
ALA A  58
 None
 0.74A 4ikiA-3fh3A:
undetectable		 4ikiA-3fh3A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR
(Bacillus
anthracis) 		4 / 5 LYS A  54
LEU A  55
GLU A  51
LEU A  89
 None
 1.21A 4k4yA-3fh3A:
undetectable		 4k4yA-3fh3A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR
(Bacillus
anthracis) 		4 / 4 LYS A  54
LEU A  55
GLU A  51
LEU A  89
 None
 1.22A 4k4yE-3fh3A:
undetectable		 4k4yE-3fh3A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR
(Bacillus
anthracis) 		4 / 5 LYS A  54
LEU A  55
GLU A  51
LEU A  89
 None
 1.24A 4k4yI-3fh3A:
undetectable		 4k4yI-3fh3A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR
(Bacillus
anthracis) 		4 / 6 GLU A 122
GLY A  67
GLY A  63
ASP A  64
 None
 0.97A 5a06D-3fh3A:
undetectable		 5a06D-3fh3A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR
(Bacillus
anthracis) 		4 / 5 MET A  82
TYR A  62
GLY A  63
GLY A  67
 None
 0.90A 5x7pA-3fh3A:
undetectable		 5x7pA-3fh3A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR
(Bacillus
anthracis) 		4 / 6 MET A  82
TYR A  62
GLY A  63
GLY A  67
 None
 0.97A 5x7pB-3fh3A:
undetectable		 5x7pB-3fh3A:
9.40