SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fhc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 12 LEU A 389
PHE A  19
LEU A 391
ILE A 310
ARG A 301
 None
 1.22A 1hrkB-3fhcA:
undetectable		 1hrkB-3fhcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 4 LEU A 317
SER A 308
TYR A 309
LEU A 315
 None
 1.08A 1xz1A-3fhcA:
undetectable		 1xz1A-3fhcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 4 LEU A 317
SER A 308
TYR A 309
LEU A 315
 None
 1.09A 1xz3A-3fhcA:
undetectable		 1xz3A-3fhcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 ARG A 348
ARG A  20
GLN A  18
HIS B 253
 None
 1.33A 2vxaA-3fhcA:
undetectable
2vxaC-3fhcA:
undetectable
2vxaE-3fhcA:
undetectable		 2vxaA-3fhcA:
10.03
2vxaC-3fhcA:
10.03
2vxaE-3fhcA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 ARG A  20
GLN A  18
ARG A 348
HIS B 253
 None
 1.33A 2vxaA-3fhcA:
undetectable
2vxaB-3fhcA:
undetectable
2vxaK-3fhcA:
undetectable		 2vxaA-3fhcA:
10.03
2vxaB-3fhcA:
10.03
2vxaK-3fhcA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 ARG A  20
GLN A  18
ARG A 348
HIS B 253
 None
 1.34A 2vxaB-3fhcA:
undetectable
2vxaC-3fhcA:
undetectable
2vxaG-3fhcA:
undetectable		 2vxaB-3fhcA:
10.03
2vxaC-3fhcA:
10.03
2vxaG-3fhcA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 ARG A 348
ARG A  20
GLN A  18
HIS B 253
 None
 1.34A 2vxaD-3fhcA:
undetectable
2vxaF-3fhcA:
undetectable
2vxaI-3fhcA:
undetectable		 2vxaD-3fhcA:
10.03
2vxaF-3fhcA:
10.03
2vxaI-3fhcA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 ARG A  20
GLN A  18
ARG A 348
HIS B 253
 None
 1.32A 2vxaD-3fhcA:
undetectable
2vxaE-3fhcA:
undetectable
2vxaL-3fhcA:
undetectable		 2vxaD-3fhcA:
10.03
2vxaE-3fhcA:
10.03
2vxaL-3fhcA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 HIS B 253
ARG A  20
GLN A  18
ARG A 348
 None
 1.34A 2vxaB-3fhcB:
undetectable
2vxaG-3fhcB:
undetectable
2vxaH-3fhcB:
undetectable		 2vxaB-3fhcB:
15.74
2vxaG-3fhcB:
15.74
2vxaH-3fhcB:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 ARG A  20
GLN A  18
ARG A 348
HIS B 253
 None
 1.34A 2vxaH-3fhcA:
undetectable
2vxaI-3fhcA:
undetectable
2vxaJ-3fhcA:
undetectable		 2vxaH-3fhcA:
10.03
2vxaI-3fhcA:
10.03
2vxaJ-3fhcA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 HIS B 253
ARG A 348
ARG A  20
GLN A  18
 None
 1.34A 2vxaD-3fhcB:
undetectable
2vxaJ-3fhcB:
undetectable
2vxaL-3fhcB:
undetectable		 2vxaD-3fhcB:
15.74
2vxaJ-3fhcB:
15.74
2vxaL-3fhcB:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 HIS B 253
ARG A  20
GLN A  18
ARG A 348
 None
 1.34A 2vxaH-3fhcB:
undetectable
2vxaJ-3fhcB:
undetectable
2vxaK-3fhcB:
undetectable		 2vxaH-3fhcB:
15.74
2vxaJ-3fhcB:
15.74
2vxaK-3fhcB:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 HIS B 253
ARG A  20
GLN A  18
ARG A 348
 None
 1.34A 2vxaA-3fhcB:
undetectable
2vxaK-3fhcB:
undetectable
2vxaL-3fhcB:
undetectable		 2vxaA-3fhcB:
15.74
2vxaK-3fhcB:
15.74
2vxaL-3fhcB:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		3 / 3 ARG A  38
GLU A 292
SER A  39
 None
 0.71A 2xkkA-3fhcA:
undetectable
2xkkC-3fhcA:
undetectable		 2xkkA-3fhcA:
19.28
2xkkC-3fhcA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		3 / 3 THR B 276
SER B 140
LYS B 144
 None
 1.01A 3aocC-3fhcB:
undetectable		 3aocC-3fhcB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 6 LEU A 144
ALA A 175
LEU A 169
SER A 173
THR A 188
 None
 1.32A 3cfqA-3fhcA:
undetectable		 3cfqA-3fhcA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 7 LEU A 144
ALA A 175
LEU A 169
SER A 173
THR A 188
 None
 1.36A 3cfqA-3fhcA:
undetectable
3cfqB-3fhcA:
undetectable		 3cfqA-3fhcA:
14.71
3cfqB-3fhcA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 12 ALA A 121
MET A  91
LEU A  98
ALA A  99
ILE A  61
 None
 0.89A 3dauA-3fhcA:
undetectable		 3dauA-3fhcA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		5 / 12 GLN B 119
PHE B 273
THR B 142
VAL B 240
LEU B 271
 None
 1.35A 3elzA-3fhcB:
undetectable		 3elzA-3fhcB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 10 ALA B 197
LEU B 168
ARG A 348
MET B 263
LEU B 166
 None
 1.27A 3erdB-3fhcB:
undetectable		 3erdB-3fhcB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 11 LEU A 144
LEU A 177
VAL A 165
SER A 173
ILE A 174
 None
 0.96A 3frbX-3fhcA:
undetectable		 3frbX-3fhcA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 9 LEU A 144
LEU A 177
VAL A 165
SER A 173
ILE A 174
 None
 0.96A 3freX-3fhcA:
undetectable		 3freX-3fhcA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		3 / 3 VAL A 152
SER A 118
LEU A 169
 None
 0.76A 3n8xA-3fhcA:
undetectable		 3n8xA-3fhcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 9 LEU A 144
ALA A 175
LEU A 169
SER A 173
THR A 188
 None
 1.39A 3ozkA-3fhcA:
undetectable		 3ozkA-3fhcA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		4 / 8 ALA B 146
GLY B 143
THR B 142
GLN B 119
 None
 0.86A 3rglA-3fhcB:
undetectable		 3rglA-3fhcB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		4 / 7 VAL B 288
LEU B 241
LEU B 272
ILE B 248
 None
 1.00A 3u5kB-3fhcB:
undetectable		 3u5kB-3fhcB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		4 / 5 VAL B 288
LEU B 241
LEU B 272
ILE B 248
 None
 0.97A 4a9jA-3fhcB:
undetectable		 4a9jA-3fhcB:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 7 ALA A 175
LEU A 169
SER A 173
THR A 188
 None
 0.95A 4d7bA-3fhcA:
undetectable		 4d7bA-3fhcA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 7 LEU A 144
ALA A 175
SER A 173
THR A 188
 None
 0.96A 4d7bA-3fhcA:
undetectable		 4d7bA-3fhcA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 7 GLY A 210
VAL A 209
ILE A 229
PHE A 287
 None
 0.87A 4fglC-3fhcA:
undetectable		 4fglC-3fhcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 6 LEU A 144
ALA A 175
LEU A 169
SER A 173
THR A 188
 None
 1.36A 4ikiB-3fhcA:
undetectable		 4ikiB-3fhcA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 7 LEU A 144
ALA A 175
LEU A 169
SER A 173
THR A 188
 None
 1.30A 4ikkA-3fhcA:
1.7
4ikkB-3fhcA:
undetectable		 4ikkA-3fhcA:
15.82
4ikkB-3fhcA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 7 LEU A 144
ALA A 175
SER A 173
THR A 188
 None
 1.10A 4iklA-3fhcA:
undetectable
4iklB-3fhcA:
undetectable		 4iklA-3fhcA:
15.82
4iklB-3fhcA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 SER A 191
ALA A 175
SER A 173
THR A 188
 None
 0.78A 4iklA-3fhcA:
undetectable
4iklB-3fhcA:
undetectable		 4iklA-3fhcA:
15.82
4iklB-3fhcA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		5 / 12 LEU B 272
PHE B 277
PRO B 292
GLN B  81
ASP B 279
 None
 1.30A 4j7xA-3fhcB:
2.3		 4j7xA-3fhcB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		5 / 12 LEU B 272
PHE B 277
PRO B 292
GLN B  81
ASP B 279
 None
 1.29A 4j7xF-3fhcB:
2.2		 4j7xF-3fhcB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		5 / 12 LEU B 272
PHE B 277
PRO B 292
GLN B  81
ASP B 279
 None
 1.35A 4j7xJ-3fhcB:
0.7		 4j7xJ-3fhcB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 SER A 101
ASP A 103
VAL A 179
THR A 180
 None
 1.14A 4lnwA-3fhcA:
undetectable		 4lnwA-3fhcA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 8 LEU A 100
LEU A 107
VAL A 125
ILE A  61
 None
 0.96A 4oj4A-3fhcA:
undetectable		 4oj4A-3fhcA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		6 / 12 SER B 116
GLY B 143
ALA B 109
MET B 110
GLY B 111
PHE B 112
 None
 1.45A 4r29B-3fhcB:
undetectable		 4r29B-3fhcB:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		5 / 12 GLY B 143
ALA B 109
MET B 110
GLY B 111
PHE B 112
 None
 1.02A 4r29C-3fhcB:
undetectable		 4r29C-3fhcB:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		6 / 12 SER B 116
GLY B 143
ALA B 109
MET B 110
GLY B 111
PHE B 112
 None
 1.47A 4r29D-3fhcB:
undetectable		 4r29D-3fhcB:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		5 / 11 LEU B  97
LEU B  99
LEU B 127
ALA B 146
LEU B 150
 None
 1.10A 4wg0B-3fhcB:
undetectable
4wg0C-3fhcB:
undetectable
4wg0D-3fhcB:
undetectable		 4wg0B-3fhcB:
7.23
4wg0C-3fhcB:
7.23
4wg0D-3fhcB:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 11 ALA B 197
LEU B 168
ARG A 348
MET B 263
LEU B 166
 None
 1.32A 4zn7B-3fhcB:
undetectable		 4zn7B-3fhcB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 12 GLY A  54
GLY A 364
LEU A  42
HIS A  96
LEU A  59
 None
 1.20A 5c0oE-3fhcA:
undetectable		 5c0oE-3fhcA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 12 VAL A 366
LEU A  98
PHE A  52
LEU A 107
THR A 106
 None
 1.23A 5hnxB-3fhcA:
undetectable		 5hnxB-3fhcA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens) 		4 / 6 VAL B 149
LEU B 153
CYH B 167
LEU B 194
 None
 1.14A 5hrqB-3fhcB:
undetectable
5hrqI-3fhcB:
undetectable
5hrqJ-3fhcB:
undetectable		 5hrqB-3fhcB:
19.42
5hrqI-3fhcB:
8.51
5hrqJ-3fhcB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		4 / 7 SER B 280
ASP A  76
PRO A  77
SER B 274
 None
 1.14A 5l1fC-3fhcB:
undetectable		 5l1fC-3fhcB:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens) 		5 / 12 ALA A  99
VAL A 198
ASP A 154
LEU A 223
LEU A 207
 None
 1.09A 5xxiA-3fhcA:
undetectable		 5xxiA-3fhcA:
23.65