SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_1
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3fhg N-GLYCOSYLASE/DNA
LYASE
(Sulfolobus
solfataricus) 		4 / 4 SER A  50
SER A  46
LEU A  74
PHE A  81
 None
 1.48A 1r5lA-3fhgA:
0.0		 1r5lA-3fhgA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3fhg N-GLYCOSYLASE/DNA
LYASE
(Sulfolobus
solfataricus) 		3 / 3 ARG A 116
ILE A 149
THR A 162
 None
 0.70A 3ia4D-3fhgA:
undetectable		 3ia4D-3fhgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3fhg N-GLYCOSYLASE/DNA
LYASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 143
ILE A 149
LEU A 193
ILE A 156
LEU A   2
 None
 1.17A 3k2hB-3fhgA:
undetectable		 3k2hB-3fhgA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3fhg N-GLYCOSYLASE/DNA
LYASE
(Sulfolobus
solfataricus) 		3 / 3 ARG A  18
LEU A 195
THR A 202
 None
 0.80A 3oxcA-3fhgA:
undetectable		 3oxcA-3fhgA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3fhg N-GLYCOSYLASE/DNA
LYASE
(Sulfolobus
solfataricus) 		4 / 6 GLU A 201
THR A 202
THR A  43
HIS A 132
 None
None
GOL  A 208 ( 4.8A)
GOL  A 208 (-3.8A)
 1.11A 4pfjB-3fhgA:
undetectable		 4pfjB-3fhgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 3fhg N-GLYCOSYLASE/DNA
LYASE
(Sulfolobus
solfataricus) 		4 / 4 PHE A 140
ASP A 141
GLY A 138
SER A 189
 SO4  A 222 (-4.5A)
GOL  A 212 (-4.3A)
None
SO4  A 222 ( 3.6A)
 1.38A 4xp9C-3fhgA:
undetectable		 4xp9C-3fhgA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3fhg N-GLYCOSYLASE/DNA
LYASE
(Sulfolobus
solfataricus) 		4 / 5 LEU A 179
LYS A 180
ALA A 183
LEU A 186
 None
 0.81A 5vkqA-3fhgA:
undetectable
5vkqD-3fhgA:
undetectable		 5vkqA-3fhgA:
8.03
5vkqD-3fhgA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3fhg N-GLYCOSYLASE/DNA
LYASE
(Sulfolobus
solfataricus) 		4 / 5 LEU A 179
LYS A 180
ALA A 183
LEU A 186
 None
 0.80A 5vkqA-3fhgA:
undetectable
5vkqB-3fhgA:
undetectable		 5vkqA-3fhgA:
8.03
5vkqB-3fhgA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3fhg N-GLYCOSYLASE/DNA
LYASE
(Sulfolobus
solfataricus) 		4 / 5 LEU A 179
LYS A 180
ALA A 183
LEU A 186
 None
 0.80A 5vkqB-3fhgA:
undetectable
5vkqC-3fhgA:
undetectable		 5vkqB-3fhgA:
8.03
5vkqC-3fhgA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3fhg N-GLYCOSYLASE/DNA
LYASE
(Sulfolobus
solfataricus) 		4 / 5 LEU A 179
LYS A 180
ALA A 183
LEU A 186
 None
 0.80A 5vkqC-3fhgA:
undetectable
5vkqD-3fhgA:
undetectable		 5vkqC-3fhgA:
8.03
5vkqD-3fhgA:
8.03