SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fhh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 ALA A 221
GLN A  59
GLU A 191
THR A  39
ARG A  43
None
1.36A 1dy4A-3fhhA:
undetectable
1dy4A-3fhhA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 10 ASP A 266
ILE A 269
GLY A 294
GLU A 298
GLY A 317
None
1.29A 1mehA-3fhhA:
undetectable
1mehA-3fhhA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
3 / 3 ARG A 104
ASP A 524
ASN A 554
None
0.88A 1nbhA-3fhhA:
undetectable
1nbhA-3fhhA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
3 / 3 ARG A 104
ASP A 524
ASN A 554
None
0.89A 1nbhD-3fhhA:
undetectable
1nbhD-3fhhA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 4 HIS A  44
VAL A 567
THR A  34
LEU A 609
PB  A 645 (-4.4A)
None
None
None
1.41A 1oq5A-3fhhA:
undetectable
1oq5A-3fhhA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 GLY A  58
GLN A  59
ARG A  43
THR A 244
ILE A 276
None
1.39A 1z95A-3fhhA:
undetectable
1z95A-3fhhA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
3 / 3 ASP A 384
ASP A 347
ASP A 380
PB  A 642 ( 2.4A)
None
PB  A 643 (-3.6A)
0.74A 2igtB-3fhhA:
undetectable
2igtB-3fhhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 11 ARG A 415
LEU A 116
ASP A 479
GLY A 532
ILE A 541
None
1.09A 2o4pA-3fhhA:
undetectable
2o4pA-3fhhA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 7 PRO A 441
TYR A 423
PRO A 342
TYR A 382
None
1.31A 2ombC-3fhhA:
undetectable
2ombD-3fhhA:
undetectable
2ombC-3fhhA:
16.43
2ombD-3fhhA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 GLY A 114
ARG A  69
VAL A 119
GLY A 118
TYR A  66
None
0.89A 2qe6A-3fhhA:
undetectable
2qe6A-3fhhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 10 GLU A 191
ILE A 193
ARG A 176
ASP A  40
ASP A 149
None
1.37A 2qeoB-3fhhA:
undetectable
2qeoB-3fhhA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 7 TYR A 217
PHE A  91
PRO A 227
LEU A  87
None
1.01A 2vcvA-3fhhA:
undetectable
2vcvA-3fhhA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
3 / 3 ARG A 296
GLU A 101
SER A 252
None
0.90A 2xkkA-3fhhA:
undetectable
2xkkC-3fhhA:
undetectable
2xkkA-3fhhA:
21.66
2xkkC-3fhhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 7 PRO A 546
ILE A 544
PRO A  46
GLY A  47
None
0.96A 2y7kA-3fhhA:
undetectable
2y7kA-3fhhA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 7 PHE A 407
PHE A 478
SER A 476
TYR A 477
None
1.41A 3hggA-3fhhA:
undetectable
3hggA-3fhhA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 GLY A 153
ASP A  93
VAL A 610
GLY A 146
ALA A  35
None
1.10A 3keeB-3fhhA:
undetectable
3keeB-3fhhA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 7 GLU A 356
ARG A  13
THR A   5
ALA A   8
None
1.29A 3mbgA-3fhhA:
undetectable
3mbgB-3fhhA:
undetectable
3mbgA-3fhhA:
12.48
3mbgB-3fhhA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 6 ALA A 170
ILE A 168
LEU A 197
ALA A  95
None
0.77A 3r9sA-3fhhA:
undetectable
3r9sA-3fhhA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 6 ALA A 170
ILE A 168
LEU A 197
ALA A  95
None
0.75A 3r9sC-3fhhA:
undetectable
3r9sC-3fhhA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 8 ALA A 170
ILE A 168
LEU A 197
ALA A  95
None
0.73A 3r9tA-3fhhA:
undetectable
3r9tA-3fhhA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 4 LEU A 154
GLY A 155
GLY A 143
THR A 144
None
0.94A 3si7A-3fhhA:
undetectable
3si7A-3fhhA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
3 / 3 ARG A 296
ASP A 248
GLN A 246
None
0.87A 4azsA-3fhhA:
undetectable
4azsA-3fhhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 6 TYR A 270
GLN A 250
ARG A 296
GLN A 246
None
1.43A 4azvA-3fhhA:
undetectable
4azvA-3fhhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 ILE A 120
THR A  49
GLY A  65
THR A 530
ILE A  48
None
1.06A 4c9oA-3fhhA:
undetectable
4c9oA-3fhhA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 ILE A 120
THR A  49
GLY A  65
THR A 530
ILE A  48
None
1.06A 4c9oB-3fhhA:
undetectable
4c9oB-3fhhA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 11 SER A 252
GLN A 203
ASP A  76
ASP A 166
ASP A 126
None
1.23A 4fevE-3fhhA:
1.1
4fevE-3fhhA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 5 THR A 401
PRO A 400
PHE A  16
ASN A 399
None
1.43A 4mf6A-3fhhA:
undetectable
4mf6A-3fhhA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 GLY A  58
GLN A  59
ARG A  43
THR A 244
ILE A 276
None
1.42A 4okbA-3fhhA:
undetectable
4okbA-3fhhA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 GLY A  58
GLN A  59
ARG A  43
THR A 244
ILE A 276
None
1.40A 4oktA-3fhhA:
undetectable
4oktA-3fhhA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
6 / 12 GLY A  58
GLN A  59
ARG A  43
THR A 244
ILE A 276
VAL A 274
None
1.37A 4okwA-3fhhA:
undetectable
4okwA-3fhhA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 GLY A  58
GLN A  59
ARG A  43
THR A 244
VAL A 274
None
1.37A 4okxA-3fhhA:
undetectable
4okxA-3fhhA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 7 ALA A 108
ALA A 411
GLU A 451
THR A 452
None
0.89A 4r1zB-3fhhA:
undetectable
4r1zB-3fhhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 ALA A 416
SER A 113
GLU A 421
GLN A 324
GLN A 290
None
1.23A 4uilH-3fhhA:
undetectable
4uilL-3fhhA:
undetectable
4uilH-3fhhA:
16.02
4uilL-3fhhA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 7 GLY A 143
GLY A 145
VAL A 636
LEU A 609
None
0.36A 5izjB-3fhhA:
undetectable
5izjB-3fhhA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 7 GLY A 143
GLY A 145
VAL A 636
LEU A 609
None
0.36A 5izjA-3fhhA:
undetectable
5izjA-3fhhA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 ASP A  26
GLU A  31
ALA A  35
THR A  90
LEU A  42
None
1.45A 5m54B-3fhhA:
undetectable
5m54B-3fhhA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 10 ILE A  61
MET A  63
VAL A  45
TYR A 122
ILE A 120
None
1.38A 5mzrA-3fhhA:
undetectable
5mzrA-3fhhA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 9 ILE A  61
MET A  63
VAL A  45
TYR A 122
ILE A 120
None
1.37A 5mzrD-3fhhA:
undetectable
5mzrD-3fhhA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 8 PHE A 414
SER A 391
THR A 370
GLY A 112
None
0.98A 5v0vA-3fhhA:
undetectable
5v0vA-3fhhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 ARG A 415
LEU A 116
ASP A 479
GLY A 532
ILE A 541
None
1.15A 6difA-3fhhA:
undetectable
6difA-3fhhA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 5 ARG A 176
GLY A 177
ASN A 189
ASP A 149
None
1.15A 6dwjB-3fhhA:
undetectable
6dwjD-3fhhA:
undetectable
6dwjB-3fhhA:
22.58
6dwjD-3fhhA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
4 / 4 ARG A  69
GLU A 421
GLU A 448
ARG A 415
None
1.24A 6fk2A-3fhhA:
undetectable
6fk2A-3fhhA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae)
5 / 12 ARG A  99
ILE A 120
SER A  15
VAL A 103
ILE A 102
None
1.47A 6gsdA-3fhhA:
undetectable
6gsdA-3fhhA:
8.52