SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 LEU A 150
ALA A 151
LEU A 127
LEU A  97
LEU A 134
None
1.28A 1gwrA-3fhtA:
undetectable
1gwrA-3fhtA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
3 / 3 ASP A 242
HIS A 425
ASP A 245
MG  A   1 ( 3.7A)
None
None
0.86A 1nw5A-3fhtA:
3.1
1nw5A-3fhtA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 12 PHE A 433
PHE A 112
LEU A 150
VAL A 149
VAL A 107
ANP  A 480 (-3.6A)
ANP  A 480 (-3.5A)
None
None
None
1.23A 1q23B-3fhtA:
undetectable
1q23B-3fhtA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
4 / 9 ILE A 258
PHE A 284
ALA A 285
VAL A 288
None
0.84A 2vufA-3fhtA:
undetectable
2vufA-3fhtA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
4 / 5 GLN A 286
PHE A 284
LEU A 241
PHE A 239
None
1.28A 3ablC-3fhtA:
undetectable
3ablJ-3fhtA:
undetectable
3ablC-3fhtA:
20.16
3ablJ-3fhtA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
4 / 5 ALA A 334
ALA A 439
TYR A 310
MET A 442
None
1.21A 3d91A-3fhtA:
undetectable
3d91A-3fhtA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 12 THR A 145
GLY A 186
LEU A 150
VAL A 156
GLN A 212
ANP  A 480 ( 3.5A)
None
None
None
None
1.23A 3fzgA-3fhtA:
3.2
3fzgA-3fhtA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
6 / 12 LEU A 438
GLY A 428
GLY A 431
ILE A 397
ASP A 398
ALA A 394
None
None
None
None
ANP  A 480 (-3.2A)
None
1.35A 3gryA-3fhtA:
3.7
3gryA-3fhtA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
4 / 5 LEU A 353
LYS A 320
GLN A 322
LEU A 324
None
1.14A 3h5gA-3fhtA:
undetectable
3h5gB-3fhtA:
undetectable
3h5gA-3fhtA:
6.07
3h5gB-3fhtA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
4 / 7 GLU A 366
LEU A 362
THR A 390
ALA A 346
None
None
U  C   3 ( 2.9A)
None
1.30A 3mbgA-3fhtA:
undetectable
3mbgB-3fhtA:
undetectable
3mbgA-3fhtA:
16.48
3mbgB-3fhtA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 ILE A 307
ILE A 455
ILE A 451
ASN A 407
VAL A 405
None
1.46A 3ohtA-3fhtA:
undetectable
3ohtB-3fhtA:
undetectable
3ohtA-3fhtA:
21.87
3ohtB-3fhtA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 11 PHE A 239
ILE A 258
ALA A 244
VAL A 289
PRO A 290
None
1.08A 3tmzA-3fhtA:
undetectable
3tmzA-3fhtA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 12 LEU A 153
LEU A 150
LEU A 123
ILE A 182
VAL A 240
None
1.26A 4f4dA-3fhtA:
undetectable
4f4dA-3fhtA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 12 SER A 116
ALA A 109
MET A 110
GLY A 111
PHE A 112
None
None
None
None
ANP  A 480 (-3.5A)
1.25A 4r29A-3fhtA:
undetectable
4r29A-3fhtA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 12 SER A 116
ALA A 109
MET A 110
GLY A 111
PHE A 112
None
None
None
None
ANP  A 480 (-3.5A)
1.20A 4r29B-3fhtA:
undetectable
4r29B-3fhtA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 12 SER A 116
ALA A 109
MET A 110
GLY A 111
PHE A 112
None
None
None
None
ANP  A 480 (-3.5A)
1.21A 4r29C-3fhtA:
undetectable
4r29C-3fhtA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 12 LEU A  99
ALA A 146
VAL A 149
GLY A 106
GLY A 186
None
ANP  A 480 ( 4.6A)
None
None
None
0.78A 4rn6B-3fhtA:
undetectable
4rn6B-3fhtA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 12 LEU A 150
ALA A 151
LEU A 127
LEU A  97
LEU A 134
None
1.06A 4xi3C-3fhtA:
undetectable
4xi3C-3fhtA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 11 LEU A 150
ALA A 151
LEU A 127
LEU A  97
LEU A 134
None
1.26A 5dxgB-3fhtA:
undetectable
5dxgB-3fhtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 GLY A 428
HIS A 425
THR A 303
ILE A 427
THR A 276
None
None
None
None
GOL  A3731 (-4.6A)
1.33A 5eeuT-3fhtA:
undetectable
5eeuU-3fhtA:
undetectable
5eeuT-3fhtA:
11.25
5eeuU-3fhtA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 GLY A 428
HIS A 425
THR A 303
ILE A 427
THR A 276
None
None
None
None
GOL  A3731 (-4.6A)
1.33A 5eevT-3fhtA:
undetectable
5eevU-3fhtA:
undetectable
5eevT-3fhtA:
11.25
5eevU-3fhtA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 GLY A 428
HIS A 425
THR A 303
ILE A 427
THR A 276
None
None
None
None
GOL  A3731 (-4.6A)
1.33A 5eewT-3fhtA:
undetectable
5eewU-3fhtA:
undetectable
5eewT-3fhtA:
11.25
5eewU-3fhtA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 GLY A 428
HIS A 425
THR A 303
ILE A 427
THR A 276
None
None
None
None
GOL  A3731 (-4.6A)
1.33A 5eexT-3fhtA:
undetectable
5eexU-3fhtA:
undetectable
5eexT-3fhtA:
11.25
5eexU-3fhtA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 GLY A 428
HIS A 425
THR A 303
ILE A 427
THR A 276
None
None
None
None
GOL  A3731 (-4.6A)
1.33A 5eeyT-3fhtA:
undetectable
5eeyU-3fhtA:
undetectable
5eeyT-3fhtA:
11.25
5eeyU-3fhtA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 GLY A 428
HIS A 425
THR A 303
ILE A 427
THR A 276
None
None
None
None
GOL  A3731 (-4.6A)
1.33A 5eezT-3fhtA:
undetectable
5eezU-3fhtA:
undetectable
5eezT-3fhtA:
11.25
5eezU-3fhtA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 GLY A 428
HIS A 425
THR A 303
ILE A 427
THR A 276
None
None
None
None
GOL  A3731 (-4.6A)
1.33A 5ef0T-3fhtA:
undetectable
5ef0U-3fhtA:
undetectable
5ef0T-3fhtA:
11.25
5ef0U-3fhtA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 GLY A 428
HIS A 425
THR A 303
ILE A 427
THR A 276
None
None
None
None
GOL  A3731 (-4.6A)
1.33A 5ef1T-3fhtA:
undetectable
5ef1U-3fhtA:
undetectable
5ef1T-3fhtA:
11.25
5ef1U-3fhtA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 GLY A 428
HIS A 425
THR A 303
ILE A 427
THR A 276
None
None
None
None
GOL  A3731 (-4.6A)
1.33A 5ef2T-3fhtA:
undetectable
5ef2U-3fhtA:
undetectable
5ef2T-3fhtA:
11.25
5ef2U-3fhtA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
5 / 10 GLY A 428
HIS A 425
THR A 303
ILE A 427
THR A 276
None
None
None
None
GOL  A3731 (-4.6A)
1.33A 5ef3T-3fhtA:
undetectable
5ef3U-3fhtA:
undetectable
5ef3T-3fhtA:
11.25
5ef3U-3fhtA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
4 / 6 VAL A 149
LEU A 153
CYH A 167
LEU A 194
None
1.17A 5hrqB-3fhtA:
undetectable
5hrqI-3fhtA:
undetectable
5hrqJ-3fhtA:
undetectable
5hrqB-3fhtA:
10.10
5hrqI-3fhtA:
5.35
5hrqJ-3fhtA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
3 / 3 ARG A 432
HIS A 425
ARG A 429
ANP  A 480 (-2.8A)
None
ANP  A 480 (-2.8A)
1.03A 5iaoC-3fhtA:
3.7
5iaoC-3fhtA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
3 / 3 ARG A 432
HIS A 425
ARG A 429
ANP  A 480 (-2.8A)
None
ANP  A 480 (-2.8A)
1.08A 5iaoF-3fhtA:
4.4
5iaoF-3fhtA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
3 / 3 ARG A 454
PRO A 418
ASN A 420
None
0.97A 5jwaA-3fhtA:
undetectable
5jwaH-3fhtA:
undetectable
5jwaA-3fhtA:
21.12
5jwaH-3fhtA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
4 / 6 ILE A 248
ILE A 215
LEU A 166
PHE A 239
None
0.94A 5vkqA-3fhtA:
undetectable
5vkqB-3fhtA:
undetectable
5vkqA-3fhtA:
13.37
5vkqB-3fhtA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
4 / 6 ILE A 248
ILE A 215
LEU A 166
PHE A 239
None
0.93A 5vkqB-3fhtA:
undetectable
5vkqC-3fhtA:
undetectable
5vkqB-3fhtA:
13.37
5vkqC-3fhtA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
4 / 6 ILE A 248
ILE A 215
LEU A 166
PHE A 239
None
0.92A 5vkqC-3fhtA:
undetectable
5vkqD-3fhtA:
undetectable
5vkqC-3fhtA:
13.37
5vkqD-3fhtA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
4 / 6 ILE A 248
ILE A 215
LEU A 166
PHE A 239
None
0.92A 5vkqA-3fhtA:
undetectable
5vkqD-3fhtA:
undetectable
5vkqA-3fhtA:
13.37
5vkqD-3fhtA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo
sapiens)
4 / 6 PRO A 218
GLY A 219
THR A 220
LYS A 227
U  C   4 ( 4.2A)
U  C   5 ( 3.1A)
U  C   5 ( 3.5A)
U  C   6 ( 2.9A)
0.85A 5xxiA-3fhtA:
undetectable
5xxiA-3fhtA:
21.91