SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fhx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 6 GLU A  61
LEU A  62
VAL A  94
MET A  93
 SO4  A 320 (-2.8A)
None
None
SO4  A 316 (-4.8A)
 0.75A 1hk1A-3fhxA:
4.0		 1hk1A-3fhxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 7 GLU A  61
LEU A  62
VAL A  94
MET A  93
 SO4  A 320 (-2.8A)
None
None
SO4  A 316 (-4.8A)
 0.75A 1hk2A-3fhxA:
3.9		 1hk2A-3fhxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 7 GLU A  61
LEU A  62
VAL A  94
MET A  93
 SO4  A 320 (-2.8A)
None
None
SO4  A 316 (-4.8A)
 0.75A 1hk3A-3fhxA:
3.8		 1hk3A-3fhxA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		5 / 10 SER A  12
VAL A  14
HIS A  46
THR A  47
VAL A 231
 PXL  A 313 (-3.3A)
None
PXL  A 313 (-4.9A)
PXL  A 313 (-2.7A)
SO4  A 314 ( 4.0A)
 0.68A 1td2A-3fhxA:
37.6		 1td2A-3fhxA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		5 / 9 HIS A  46
THR A  47
TYR A  84
VAL A 115
VAL A 231
 PXL  A 313 (-4.9A)
PXL  A 313 (-2.7A)
PXL  A 313 ( 4.6A)
ATP  A 407 ( 4.5A)
SO4  A 314 ( 4.0A)
 0.87A 1td2B-3fhxA:
37.8		 1td2B-3fhxA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		5 / 9 SER A  12
HIS A  46
THR A  47
VAL A 115
VAL A 231
 PXL  A 313 (-3.3A)
PXL  A 313 (-4.9A)
PXL  A 313 (-2.7A)
ATP  A 407 ( 4.5A)
SO4  A 314 ( 4.0A)
 0.91A 1td2B-3fhxA:
37.8		 1td2B-3fhxA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		3 / 3 MET A 221
ASN A 251
GLN A 205
 None
 0.97A 1xoqB-3fhxA:
undetectable		 1xoqB-3fhxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 4 ILE A  97
ASP A  60
LEU A  57
ARG A  70
 None
None
None
SO4  A 316 (-3.0A)
 1.30A 2a7qA-3fhxA:
2.4		 2a7qA-3fhxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		3 / 3 LEU A  28
PRO A  27
LEU A  31
 None
 0.61A 2po5B-3fhxA:
3.4		 2po5B-3fhxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		5 / 9 THR A 148
PRO A 149
VAL A 183
ALA A 144
PRO A 114
 None
NA  A 402 (-4.8A)
None
None
None
 1.50A 2v41A-3fhxA:
undetectable
2v41B-3fhxA:
undetectable		 2v41A-3fhxA:
22.01
2v41B-3fhxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		5 / 9 PRO A 114
THR A 148
PRO A 149
VAL A 183
ALA A 144
 None
None
NA  A 402 (-4.8A)
None
None
 1.49A 2v41A-3fhxA:
undetectable
2v41B-3fhxA:
undetectable		 2v41A-3fhxA:
22.01
2v41B-3fhxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 6 LEU A 132
VAL A 135
VAL A  94
VAL A  95
 None
 0.99A 2z97A-3fhxA:
undetectable		 2z97A-3fhxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 238
LEU A 241
LEU A 252
ALA A 309
 None
 1.24A 3ozuA-3fhxA:
undetectable		 3ozuA-3fhxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 7 ILE A 219
GLY A 203
PHE A 237
LEU A 241
 None
None
ATP  A 407 ( 4.8A)
None
 0.89A 3v7pA-3fhxA:
2.7		 3v7pA-3fhxA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 8 LEU A   8
VAL A  94
LEU A  69
TYR A  77
 None
 1.07A 3v81A-3fhxA:
undetectable		 3v81A-3fhxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 8 LEU A   8
VAL A  94
LEU A  69
TYR A  77
 None
 1.02A 3v81C-3fhxA:
undetectable		 3v81C-3fhxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		5 / 8 VAL A 183
VAL A 184
CYH A 256
LEU A 241
ASP A 113
 None
None
None
None
ATP  A 407 ( 3.3A)
 1.45A 3wzeA-3fhxA:
undetectable		 3wzeA-3fhxA:
24.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 5 SER A  12
GLY A  20
THR A  47
VAL A 231
 PXL  A 313 (-3.3A)
None
PXL  A 313 (-2.7A)
SO4  A 314 ( 4.0A)
 0.18A 4eohA-3fhxA:
51.8		 4eohA-3fhxA:
99.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 5 SER A  12
HIS A  46
TYR A  84
VAL A 231
 PXL  A 313 (-3.3A)
PXL  A 313 (-4.9A)
PXL  A 313 ( 4.6A)
SO4  A 314 ( 4.0A)
 0.24A 4eohB-3fhxA:
51.4		 4eohB-3fhxA:
99.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 8 LEU A   8
VAL A  94
LEU A  69
TYR A  77
 None
 0.99A 4puoC-3fhxA:
undetectable		 4puoC-3fhxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 8 LEU A   8
VAL A  94
LEU A  69
TYR A  77
 None
 1.05A 4pwdC-3fhxA:
undetectable		 4pwdC-3fhxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		5 / 11 GLY A 234
ALA A 235
THR A  82
GLY A  83
VAL A  14
 SO4  A 314 (-3.5A)
SO4  A 314 (-3.6A)
None
None
None
 0.86A 4qgiA-3fhxA:
undetectable		 4qgiA-3fhxA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 7 THR A 233
LEU A 236
LEU A 263
THR A 270
 ATP  A 407 (-3.4A)
None
ATP  A 407 ( 4.1A)
None
 0.91A 4z90A-3fhxA:
2.4
4z90B-3fhxA:
2.4
4z90C-3fhxA:
undetectable
4z90D-3fhxA:
2.3
4z90E-3fhxA:
undetectable		 4z90A-3fhxA:
22.01
4z90B-3fhxA:
22.01
4z90C-3fhxA:
22.01
4z90D-3fhxA:
22.01
4z90E-3fhxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 8 ALA A 255
THR A 259
THR A 262
ALA A  24
 None
 0.97A 5x2tI-3fhxA:
undetectable
5x2tJ-3fhxA:
undetectable
5x2tK-3fhxA:
undetectable
5x2tL-3fhxA:
undetectable		 5x2tI-3fhxA:
17.63
5x2tJ-3fhxA:
19.18
5x2tK-3fhxA:
17.63
5x2tL-3fhxA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 8 ALA A 255
THR A 259
THR A 262
ALA A 235
 None
None
None
SO4  A 314 (-3.6A)
 0.95A 5x2tI-3fhxA:
undetectable
5x2tJ-3fhxA:
undetectable
5x2tK-3fhxA:
undetectable
5x2tL-3fhxA:
undetectable		 5x2tI-3fhxA:
17.63
5x2tJ-3fhxA:
19.18
5x2tK-3fhxA:
17.63
5x2tL-3fhxA:
19.18