SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		5 / 12 THR A 259
ALA A 260
ASP A 261
MET A 379
ILE A 367
 None
 1.02A 1errA-3fibA:
undetectable		 1errA-3fibA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		5 / 10 ALA A 341
ALA A 289
LEU A 250
MET A 384
VAL A 248
 None
 1.09A 2wuzA-3fibA:
undetectable		 2wuzA-3fibA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		5 / 10 ALA A 341
ALA A 289
LEU A 250
MET A 384
VAL A 248
 None
 1.07A 2wuzB-3fibA:
undetectable		 2wuzB-3fibA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		4 / 7 TYR A 274
GLU A 213
TRP A 208
ASN A 317
 None
 1.13A 3k8mA-3fibA:
undetectable		 3k8mA-3fibA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		4 / 7 PHE A 204
GLY A 346
GLY A 200
PHE A 312
 None
 0.84A 3ko0M-3fibA:
undetectable
3ko0P-3fibA:
undetectable		 3ko0M-3fibA:
18.33
3ko0P-3fibA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		3 / 3 GLN A 210
THR A 314
ASN A 207
 None
 0.88A 3v4tE-3fibA:
undetectable		 3v4tE-3fibA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		4 / 7 PHE A 215
TYR A 211
GLN A 195
PHE A 312
 None
 1.41A 4grqA-3fibA:
undetectable
4grqC-3fibA:
undetectable		 4grqA-3fibA:
16.06
4grqC-3fibA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		4 / 7 PHE A 215
TYR A 211
TRP A 227
PHE A 312
 None
 1.19A 4grqA-3fibA:
undetectable
4grqC-3fibA:
undetectable		 4grqA-3fibA:
16.06
4grqC-3fibA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		5 / 12 MET A 384
VAL A 248
LEU A 246
PHE A 295
ALA A 289
 None
 1.05A 4o1zB-3fibA:
undetectable		 4o1zB-3fibA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		3 / 3 TYR A 348
LYS A 381
LYS A 380
 None
 1.08A 5dbyA-3fibA:
undetectable		 5dbyA-3fibA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_A_K1SA304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		4 / 5 GLU A 183
TRP A 191
VAL A 193
LEU A 246
 None
 1.43A 5qjqA-3fibA:
0.0
5qjqB-3fibA:
0.0		 5qjqA-3fibA:
20.08
5qjqB-3fibA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_B_K1SB304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		4 / 5 TRP A 191
VAL A 193
LEU A 246
GLU A 183
 None
 1.42A 5qjqA-3fibA:
0.0
5qjqB-3fibA:
0.0		 5qjqA-3fibA:
20.08
5qjqB-3fibA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_C_K1SC305_0
(ADP-SUGAR
PYROPHOSPHATASE)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		4 / 5 GLU A 183
TRP A 191
VAL A 193
LEU A 246
 None
 1.46A 5qjqC-3fibA:
0.0
5qjqD-3fibA:
0.0		 5qjqC-3fibA:
20.08
5qjqD-3fibA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		4 / 8 THR A 353
TYR A 377
THR A 374
ARG A 375
 None
 1.34A 5tzoB-3fibA:
undetectable		 5tzoB-3fibA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		4 / 5 HIS A 343
SER A 332
TYR A 211
GLY A 333
 None
 1.43A 5yodH-3fibA:
undetectable		 5yodH-3fibA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		5 / 12 LEU A 344
HIS A 340
PHE A 293
TYR A 262
ALA A 260
 None
 1.23A 6qyaB-3fibA:
undetectable		 6qyaB-3fibA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 3fib FIBRINOGEN GAMMA
CHAIN RESIDUES
(Homo
sapiens) 		5 / 12 LEU A 344
HIS A 340
PHE A 293
TYR A 262
ALA A 260
 None
 1.22A 6qyaD-3fibA:
undetectable		 6qyaD-3fibA:
21.43