SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		4 / 5 LEU A 239
ALA A  78
ILE A 137
SER A  80
 None
 1.13A 2othA-3fidA:
undetectable		 2othA-3fidA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		3 / 3 SER A 286
ASP A 283
ASP A  29
 None
None
ZN  A 300 (-2.1A)
 0.80A 2plwA-3fidA:
undetectable		 2plwA-3fidA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		5 / 12 ASP A  32
THR A 233
ASN A 231
VAL A 228
TYR A 178
 None
GOL  A 302 (-3.8A)
GOL  A 302 (-3.3A)
None
None
 1.38A 2x0yB-3fidA:
undetectable		 2x0yB-3fidA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		3 / 3 GLY A 180
TYR A 178
SER A 169
 None
 0.76A 2xatA-3fidA:
undetectable		 2xatA-3fidA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		4 / 5 SER A   6
GLY A 200
GLU A 167
GLU A 224
 None
 1.34A 3raeB-3fidA:
undetectable
3raeD-3fidA:
undetectable		 3raeB-3fidA:
20.60
3raeD-3fidA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		5 / 12 TYR A  33
ILE A 137
LEU A 234
GLU A 278
ARG A  77
 None
None
None
GOL  A 302 (-2.7A)
GOL  A 302 (-3.1A)
 1.22A 4b9zA-3fidA:
undetectable		 4b9zA-3fidA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		4 / 7 PHE A 176
VAL A 171
GLY A 200
PHE A  82
 GOL  A 302 (-4.3A)
None
None
None
 0.97A 4ejjB-3fidA:
undetectable		 4ejjB-3fidA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		6 / 12 LEU A 270
GLY A  13
ALA A  12
ASP A  11
ASP A  10
ILE A 288
 None
None
None
None
GOL  A 303 ( 2.8A)
None
 1.34A 4jecA-3fidA:
undetectable		 4jecA-3fidA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		4 / 4 ILE A  59
SER A  80
ASP A  10
ASP A  29
 None
None
GOL  A 303 ( 2.8A)
ZN  A 300 (-2.1A)
 1.41A 4krhB-3fidA:
undetectable		 4krhB-3fidA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		5 / 12 GLY A  31
ASP A  29
ILE A  59
SER A 286
ASN A   9
 None
ZN  A 300 (-2.1A)
None
None
GOL  A 303 ( 3.1A)
 1.20A 4obwC-3fidA:
undetectable		 4obwC-3fidA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		5 / 12 ALA A 112
GLY A 113
ILE A 108
GLY A 106
ASN A 139
 None
 1.29A 4obwD-3fidA:
undetectable		 4obwD-3fidA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		3 / 3 VAL A 223
ALA A 183
PHE A 199
 CXE  A 307 (-4.3A)
CXE  A 306 ( 4.4A)
None
 0.82A 4olbA-3fidA:
undetectable		 4olbA-3fidA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		3 / 3 VAL A 223
ALA A 183
PHE A 199
 CXE  A 307 (-4.3A)
CXE  A 306 ( 4.4A)
None
 0.85A 4w5nA-3fidA:
undetectable		 4w5nA-3fidA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		3 / 3 ASP A  32
ARG A 256
ARG A 226
 None
None
GOL  A 302 (-4.5A)
 0.84A 5eajB-3fidA:
undetectable		 5eajB-3fidA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		4 / 5 TYR A 287
ILE A 288
LEU A  37
GLY A  36
 None
 0.96A 5kmdC-3fidA:
undetectable
5kmdD-3fidA:
undetectable		 5kmdC-3fidA:
21.16
5kmdD-3fidA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)
(Salmonella
enterica) 		5 / 12 THR A 192
ASP A 196
SER A   1
SER A   2
ASN A  90
 None
None
ZN  A 298 ( 1.8A)
None
None
 1.31A 6h7jB-3fidA:
undetectable		 6h7jB-3fidA:
13.88