SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 0.91A 1j36A-3fiiA:
2.3		 1j36A-3fiiA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 0.91A 1j36B-3fiiA:
2.1		 1j36B-3fiiA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 11 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 0.87A 1j37A-3fiiA:
2.6		 1j37A-3fiiA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 11 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 0.88A 1j37B-3fiiA:
2.4		 1j37B-3fiiA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 6 VAL A  14
ILE A  19
TRP A  44
LEU A 154
 None
 1.30A 1j96A-3fiiA:
undetectable		 1j96A-3fiiA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 GLU A 200
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 None
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 1.18A 1o86A-3fiiA:
2.5		 1o86A-3fiiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 0.91A 1o86A-3fiiA:
2.5		 1o86A-3fiiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 LEU A 236
TYR A 237
LEU A 107
LEU A 108
MET A  40
 None
 1.46A 1p33C-3fiiA:
undetectable		 1p33C-3fiiA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 6 TYR A 349
TYR A 345
GLU A 265
VAL A 242
 None
 1.20A 1q13A-3fiiA:
undetectable		 1q13A-3fiiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 0.87A 2c6nA-3fiiA:
3.1		 2c6nA-3fiiA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 0.95A 2c6nB-3fiiA:
undetectable		 2c6nB-3fiiA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 7 ARG A  49
GLY A 159
SER A 196
GLU A 198
 None
 1.04A 2c8aB-3fiiA:
undetectable		 2c8aB-3fiiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 7 ARG A  49
GLY A 159
SER A 196
GLU A 198
 None
 0.99A 2c8aD-3fiiA:
undetectable		 2c8aD-3fiiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 GLU A 200
GLU A 353
ARG A 365
TYR A 368
TYR A 372
 None
None
None
00C  B  58 (-4.8A)
None
 1.46A 2htqA-3fiiA:
undetectable		 2htqA-3fiiA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 11 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 0.86A 2x8zA-3fiiA:
2.3		 2x8zA-3fiiA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 0.89A 2x91A-3fiiA:
undetectable		 2x91A-3fiiA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 5 PRO A  25
VAL A 137
THR A 123
GLY A 119
 None
 1.17A 3elzB-3fiiA:
undetectable		 3elzB-3fiiA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 9 HIS A 231
ASN A 191
HIS A 234
GLY A 235
THR A 269
 ZN  A 822 (-3.4A)
None
None
None
None
 1.30A 3gn0A-3fiiA:
undetectable		 3gn0A-3fiiA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		3 / 3 HIS A 227
GLU A 228
HIS A 231
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
 0.15A 3kecB-3fiiA:
undetectable		 3kecB-3fiiA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 8 LEU A 290
VAL A 336
TYR A 324
LEU A 348
 None
 0.85A 3v81A-3fiiA:
undetectable		 3v81A-3fiiA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 11 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 0.89A 4c2pA-3fiiA:
2.6		 4c2pA-3fiiA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 ALA A 226
ASN A 101
ALA A 103
GLY A 104
LEU A 107
 None
 1.04A 4oaeA-3fiiA:
undetectable		 4oaeA-3fiiA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 8 LEU A 290
VAL A 336
TYR A 324
LEU A 348
 None
 0.76A 4puoC-3fiiA:
undetectable		 4puoC-3fiiA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 368
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
ZN  A 822 ( 2.0A)
00C  B  58 (-4.8A)
 0.48A 4r7lA-3fiiA:
3.5		 4r7lA-3fiiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 10 LEU A 268
LEU A 275
TYR A 349
SER A 350
ILE A 278
 None
 1.15A 4xj7C-3fiiA:
undetectable
4xj7D-3fiiA:
undetectable		 4xj7C-3fiiA:
20.28
4xj7D-3fiiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		6 / 12 VAL A   3
LEU A 229
LEU A 225
ILE A  98
VAL A 155
LEU A 153
 None
 1.43A 4y0sA-3fiiA:
undetectable		 4y0sA-3fiiA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 7 GLY A 186
GLY A 188
SER A 189
ASP A 185
 None
 0.79A 5ergB-3fiiA:
undetectable		 5ergB-3fiiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3fii BOTULINUM NEUROTOXIN
TYPE F
FRAGMENT OF
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 2
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 THR A 243
ASP B  57
GLU B  55
 None
 0.81A 5fa8A-3fiiA:
undetectable		 5fa8A-3fiiA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3fii BOTULINUM NEUROTOXIN
TYPE F
FRAGMENT OF
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 2
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 ILE A  52
GLY A  53
ASN B  49
ASP B  51
 None
 0.94A 5hieD-3fiiA:
undetectable		 5hieD-3fiiA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3fii BOTULINUM NEUROTOXIN
TYPE F
FRAGMENT OF
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 2
(Clostridium
botulinum;
Homo
sapiens) 		4 / 6 GLY A 186
ASP B  57
ILE A 230
TYR A 349
 None
 0.82A 5iwuA-3fiiA:
undetectable		 5iwuA-3fiiA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 7 LEU A 236
ILE A 139
MET A  22
TRP A  44
 None
 1.37A 5ljcA-3fiiA:
undetectable		 5ljcA-3fiiA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 4 HIS A 231
HIS A 227
TYR A 368
GLU A 266
 ZN  A 822 (-3.4A)
ZN  A 822 ( 3.5A)
00C  B  58 (-4.8A)
ZN  A 822 ( 2.0A)
 1.30A 5pahA-3fiiA:
undetectable		 5pahA-3fiiA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		5 / 12 LEU A 381
ALA A  82
THR A  80
ILE A 162
GLY A 157
 None
 0.91A 5veuB-3fiiA:
undetectable		 5veuB-3fiiA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 5 ASN A 358
ASN A 366
ASP A 205
ASN A 401
 None
 1.38A 5vooA-3fiiA:
undetectable		 5vooA-3fiiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 5 ASN A 358
ASN A 366
ASP A 205
ASN A 401
 None
 1.40A 5vooC-3fiiA:
undetectable		 5vooC-3fiiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 5 ASN A 358
ASN A 366
ASP A 205
ASN A 401
 None
 1.40A 5vooE-3fiiA:
undetectable		 5vooE-3fiiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 3fii BOTULINUM NEUROTOXIN
TYPE F
(Clostridium
botulinum) 		4 / 4 LEU A 380
ASP A 220
PRO A 221
ARG A  97
 None
 0.96A 6fgdA-3fiiA:
1.7		 6fgdA-3fiiA:
22.29