SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fiu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 11 ILE A 187
ILE A  34
LEU A 166
PRO A 165
ILE A  40
 None
None
None
None
POP  A4001 (-4.9A)
 1.07A 1dg5A-3fiuA:
undetectable		 1dg5A-3fiuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 10 ALA A  45
GLY A  39
ILE A 187
ALA A  58
ILE A  34
 None
POP  A4001 (-3.3A)
None
None
None
 1.00A 3ekwA-3fiuA:
undetectable		 3ekwA-3fiuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 6 VAL A 174
SER A  47
LEU A 128
ILE A  83
LEU A 166
 None
 1.45A 3kk6A-3fiuA:
undetectable		 3kk6A-3fiuA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		4 / 7 ARG A 137
ALA A  45
VAL A 183
ILE A  34
 None
 0.90A 3wsjB-3fiuA:
undetectable		 3wsjB-3fiuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		4 / 6 GLU A 205
PRO A 192
TRP A 233
GLU A 203
 None
POP  A4001 (-3.7A)
None
None
 1.49A 4a7tA-3fiuA:
0.0		 4a7tA-3fiuA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		4 / 6 GLU A 205
PRO A 192
TRP A 233
GLU A 203
 None
POP  A4001 (-3.7A)
None
None
 1.49A 4a7uA-3fiuA:
0.0		 4a7uA-3fiuA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 12 ILE A 187
ILE A  34
LEU A 166
PRO A 165
ILE A  40
 None
None
None
None
POP  A4001 (-4.9A)
 1.01A 4m2xA-3fiuA:
undetectable		 4m2xA-3fiuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 12 ILE A 187
ILE A  34
LEU A 166
PRO A 165
ILE A  40
 None
None
None
None
POP  A4001 (-4.9A)
 1.03A 4m2xC-3fiuA:
undetectable		 4m2xC-3fiuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 12 ILE A 187
ILE A  34
LEU A 166
PRO A 165
ILE A  40
 None
None
None
None
POP  A4001 (-4.9A)
 1.01A 4m2xE-3fiuA:
undetectable		 4m2xE-3fiuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 12 ILE A 187
ILE A  34
LEU A 166
PRO A 165
ILE A  40
 None
None
None
None
POP  A4001 (-4.9A)
 1.04A 4m2xG-3fiuA:
undetectable		 4m2xG-3fiuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 12 ASN A  66
GLY A 195
GLN A 200
LEU A 113
GLN A  91
 AMP  A3001 ( 3.7A)
None
None
None
None
 1.30A 4p6xE-3fiuA:
undetectable		 4p6xE-3fiuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 12 ASN A  66
GLY A 195
GLN A 200
LEU A 113
GLN A  91
 AMP  A3001 ( 3.7A)
None
None
None
None
 1.29A 4p6xG-3fiuA:
undetectable		 4p6xG-3fiuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 11 ARG A 122
LEU A 113
GLU A 205
ALA A 194
LEU A 196
 None
None
None
AMP  A3001 (-3.7A)
None
 1.11A 4wg0H-3fiuA:
undetectable
4wg0I-3fiuA:
undetectable
4wg0J-3fiuA:
undetectable		 4wg0H-3fiuA:
6.40
4wg0I-3fiuA:
6.40
4wg0J-3fiuA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 12 ILE A  90
TYR A  86
GLU A  84
THR A  57
LEU A  61
 None
None
None
None
AMP  A3001 (-4.2A)
 1.19A 5ienB-3fiuA:
undetectable		 5ienB-3fiuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		4 / 4 GLY A 195
ARG A 124
ASN A  66
LEU A 196
 None
AMP  A3001 (-3.8A)
AMP  A3001 ( 3.7A)
None
 1.32A 6b58A-3fiuA:
undetectable		 6b58A-3fiuA:
16.96