SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 HIS A  63
ASN A  82
PHE A  86
HIS A 100
VAL A 112
 None
 0.81A 2xpvA-3fiwA:
17.3		 2xpvA-3fiwA:
39.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 TYR A  44
LEU A  51
LEU A  30
SER A  40
 None
 0.92A 3lm8A-3fiwA:
undetectable
3lm8C-3fiwA:
undetectable		 3lm8A-3fiwA:
21.67
3lm8C-3fiwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 TYR A  44
LEU A  51
LEU A  30
SER A  40
 None
 0.91A 3lm8B-3fiwA:
undetectable
3lm8D-3fiwA:
undetectable		 3lm8B-3fiwA:
21.67
3lm8D-3fiwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 TYR A  44
LEU A  51
LEU A  30
SER A  40
 None
 0.69A 3lm8A-3fiwA:
undetectable
3lm8C-3fiwA:
undetectable		 3lm8A-3fiwA:
21.67
3lm8C-3fiwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 ALA A 132
ALA A 135
ALA A 136
THR A 140
LEU A  80
 None
 1.13A 4j6cA-3fiwA:
undetectable		 4j6cA-3fiwA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A 132
ALA A 135
ALA A 136
THR A 140
LEU A  80
 None
 1.12A 4j6cB-3fiwA:
undetectable		 4j6cB-3fiwA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 HIS A  63
ASN A  82
PHE A  86
HIS A 100
VAL A 112
 None
 0.87A 4v2gB-3fiwA:
17.3		 4v2gB-3fiwA:
39.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ASP A  95
VAL A  25
LEU A  52
 None
 0.68A 5e5jB-3fiwA:
undetectable		 5e5jB-3fiwA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 MET A   4
ASN A   5
TYR A  44
SER A  26
ARG A  28
 None
 1.38A 5lsaA-3fiwA:
undetectable		 5lsaA-3fiwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 ARG A   6
MET A  55
THR A  53
LEU A  52
 None
 1.40A 6nknJ-3fiwA:
undetectable		 6nknJ-3fiwA:
11.48