SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQU_A_ESTA304_1
(ESTROGEN
SULFOTRANSFERASE)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 11 CYH A1268
HIS A1378
PHE A1400
SER A1326
GLU A1327
 None
 1.49A 1aquA-3fk2A:
0.0
1aquB-3fk2A:
0.0		 1aquA-3fk2A:
23.00
1aquB-3fk2A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		3 / 3 LEU A1277
HIS A1378
LYS A1381
 None
 1.07A 1y7iA-3fk2A:
undetectable		 1y7iA-3fk2A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 12 ILE A1265
LEU A1307
SER A1323
LYS A1322
ILE A1269
 None
 1.12A 3cd2A-3fk2A:
undetectable		 3cd2A-3fk2A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 8 TYR A1283
GLU A1273
PHE A1400
ILE A1425
 None
 1.05A 3jz0B-3fk2A:
undetectable		 3jz0B-3fk2A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 7 ALA A1274
TYR A1271
ARG A1267
ALA A1308
 None
 1.13A 3twpB-3fk2A:
undetectable		 3twpB-3fk2A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 7 ALA A1274
TYR A1271
ARG A1267
ALA A1308
 None
 1.05A 3twpC-3fk2A:
undetectable		 3twpC-3fk2A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		3 / 3 GLY A1287
THR A1316
ASN A1288
 None
 0.54A 3v4tD-3fk2A:
undetectable		 3v4tD-3fk2A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 8 SER A1383
GLU A1426
ILE A1429
ASN A1386
 None
 1.07A 4d39A-3fk2A:
undetectable		 4d39A-3fk2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 7 SER A1383
GLU A1426
ILE A1429
ASN A1386
 None
 1.05A 4d39B-3fk2A:
undetectable		 4d39B-3fk2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		3 / 3 PRO A1433
ASN A1380
HIS A1384
 None
 0.55A 4ma3H-3fk2A:
undetectable
4ma3L-3fk2A:
undetectable		 4ma3H-3fk2A:
20.73
4ma3L-3fk2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 7 LEU A1341
THR A1403
MET A1337
LEU A1361
 None
 1.07A 5jq7B-3fk2A:
undetectable		 5jq7B-3fk2A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A1312
LEU A1307
ILE A1261
ALA A1320
 None
 0.80A 6b5vA-3fk2A:
undetectable
6b5vC-3fk2A:
0.0		 6b5vA-3fk2A:
15.57
6b5vC-3fk2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 7 ALA A1320
PHE A1312
LEU A1307
ILE A1261
 None
 0.82A 6b5vA-3fk2A:
undetectable
6b5vB-3fk2A:
undetectable		 6b5vA-3fk2A:
15.57
6b5vB-3fk2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A1312
LEU A1307
ILE A1261
ALA A1320
 None
 0.79A 6b5vC-3fk2A:
undetectable
6b5vD-3fk2A:
undetectable		 6b5vC-3fk2A:
15.57
6b5vD-3fk2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 7 ALA A1320
PHE A1312
LEU A1307
ILE A1261
 None
 0.81A 6b5vB-3fk2A:
undetectable
6b5vD-3fk2A:
undetectable		 6b5vB-3fk2A:
15.57
6b5vD-3fk2A:
15.57