SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 3fk3 PROTEIN AF-9 HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  57
GLU A  53
PHE A 150
GLY A  49
 None
 1.02A 2ha4A-3fk3A:
undetectable		 2ha4A-3fk3A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3fk3 PROTEIN AF-9 HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  49
PHE A  58
ILE A  59
PHE A 155
 None
 0.87A 2qmzA-3fk3A:
undetectable
2qmzB-3fk3A:
undetectable		 2qmzA-3fk3A:
19.49
2qmzB-3fk3A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3fk3 PROTEIN AF-9 HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 GLY A  49
PHE A  58
ILE A  59
PHE A 155
 None
 0.93A 4qogA-3fk3A:
undetectable
4qogB-3fk3A:
undetectable		 4qogA-3fk3A:
19.41
4qogB-3fk3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3fk3 PROTEIN AF-9 HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  96
GLY A  49
ILE A  59
PHE A 100
PHE A 155
 None
 1.17A 4qoiA-3fk3A:
undetectable
4qoiB-3fk3A:
undetectable		 4qoiA-3fk3A:
19.41
4qoiB-3fk3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3fk3 PROTEIN AF-9 HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  96
GLY A  49
PHE A  58
ILE A  59
PHE A 155
 None
 1.07A 4qoiA-3fk3A:
undetectable
4qoiB-3fk3A:
undetectable		 4qoiA-3fk3A:
19.41
4qoiB-3fk3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3fk3 PROTEIN AF-9 HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 4 ARG A  75
HIS A  39
ALA A  35
GLU A  86
 None
 1.32A 5a06A-3fk3A:
0.0
5a06F-3fk3A:
0.0		 5a06A-3fk3A:
16.87
5a06F-3fk3A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3fk3 PROTEIN AF-9 HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 153
ASP A  54
VAL A  47
ALA A  79
VAL A  62
 None
 1.03A 5igjA-3fk3A:
undetectable		 5igjA-3fk3A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fk3 PROTEIN AF-9 HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  96
PHE A  64
ARG A  48
THR A  23
 None
 1.27A 5z84N-3fk3A:
undetectable
5z84W-3fk3A:
undetectable		 5z84N-3fk3A:
13.57
5z84W-3fk3A:
15.72