SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fk4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		4 / 5 LEU A  93
LEU A 284
LEU A 286
LEU A 108
 None
 1.14A 1yajD-3fk4A:
undetectable		 1yajD-3fk4A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		4 / 5 LEU A 222
LEU A 237
LEU A 238
LEU A 252
 None
 1.14A 1yajD-3fk4A:
undetectable		 1yajD-3fk4A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		3 / 3 LYS A 118
ASP A 354
ASP A 325
 None
 0.89A 2br4D-3fk4A:
undetectable		 2br4D-3fk4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		4 / 4 ILE A  92
PHE A  85
ILE A   4
THR A  94
 None
 1.16A 3ia4A-3fk4A:
undetectable		 3ia4A-3fk4A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		3 / 3 GLU A 181
GLU A 224
ASN A 225
 None
 0.91A 3lp9B-3fk4A:
undetectable
3lp9D-3fk4A:
undetectable		 3lp9B-3fk4A:
18.20
3lp9D-3fk4A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		5 / 10 ILE A 258
ALA A 229
LEU A 252
LEU A 215
VAL A 213
 None
 1.16A 3o02A-3fk4A:
undetectable
3o02B-3fk4A:
undetectable		 3o02A-3fk4A:
20.97
3o02B-3fk4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A 390
GLY A 372
GLY A 373
LEU A 402
GLY A 169
 None
 0.93A 4dc3B-3fk4A:
undetectable		 4dc3B-3fk4A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		5 / 10 LEU A 299
ALA A 295
GLY A 127
ILE A 131
VAL A 334
 None
 0.86A 4dqbB-3fk4A:
undetectable		 4dqbB-3fk4A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		5 / 10 LEU A 299
ALA A 295
GLY A 127
ILE A 131
VAL A 334
 None
 0.83A 4dqeB-3fk4A:
undetectable		 4dqeB-3fk4A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		5 / 10 LEU A 299
ALA A 295
GLY A 127
ILE A 131
VAL A 334
 None
 0.87A 4dqhB-3fk4A:
undetectable		 4dqhB-3fk4A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		4 / 6 ARG A 190
GLY A 194
ALA A 229
GLN A 165
 None
 1.08A 4g0uA-3fk4A:
undetectable		 4g0uA-3fk4A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		3 / 3 LYS A  72
ARG A  73
HIS A  11
 None
 1.05A 4zbrA-3fk4A:
undetectable		 4zbrA-3fk4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		4 / 6 LEU A 100
ILE A  24
ALA A  25
THR A  29
 None
 0.67A 4zf8A-3fk4A:
undetectable		 4zf8A-3fk4A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		5 / 12 TYR A 292
LEU A 289
THR A   7
PHE A 121
THR A  94
 None
 1.16A 5eskA-3fk4A:
undetectable		 5eskA-3fk4A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		4 / 6 PHE A 300
SER A 333
VAL A 355
ASP A 350
 None
 1.24A 5hesA-3fk4A:
undetectable		 5hesA-3fk4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		5 / 9 ALA A 232
GLN A 231
PRO A 186
LEU A 187
ILE A 191
 None
 1.25A 5i73A-3fk4A:
undetectable		 5i73A-3fk4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		4 / 4 PHE A 297
LEU A 198
LEU A 135
VAL A 173
 None
 1.08A 5xxiA-3fk4A:
undetectable		 5xxiA-3fk4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3fk4 RUBISCO-LIKE PROTEIN
(Bacillus
cereus) 		5 / 12 PHE A 332
LEU A 321
ASP A 129
GLY A 127
LEU A 142
 None
 1.07A 6dwnC-3fk4A:
undetectable		 6dwnC-3fk4A:
12.01