SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 11 VAL A 267
SER A 327
LEU A 233
THR A 230
THR A 228
 None
 1.25A 1dmyA-3fk5A:
undetectable		 1dmyA-3fk5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_B_AZMB900_1
(MURINE CARBONIC
ANHYDRASE V)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 12 SER A 327
VAL A 267
LEU A 233
THR A 230
THR A 228
 None
 1.14A 1dmyB-3fk5A:
undetectable		 1dmyB-3fk5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 12 LEU A  54
SER A  22
ILE A  25
ARG A  28
LEU A 161
 None
 1.10A 1dreA-3fk5A:
undetectable		 1dreA-3fk5A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		4 / 5 LEU A 161
VAL A 156
TYR A 157
THR A 160
 None
 1.33A 1nw3A-3fk5A:
undetectable		 1nw3A-3fk5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 12 LEU A  54
SER A  22
ILE A  25
ARG A  28
LEU A 161
 None
 1.14A 1rh3A-3fk5A:
undetectable		 1rh3A-3fk5A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		3 / 3 LYS A 307
ASP A  56
ASP A  15
 None
 0.99A 2br4D-3fk5A:
undetectable		 2br4D-3fk5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		4 / 6 LEU A 305
ILE A 320
ARG A 313
GLY A 312
 None
 0.90A 2du8A-3fk5A:
undetectable		 2du8A-3fk5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		4 / 6 LEU A 305
ILE A 320
ARG A 313
GLY A 312
 None
 0.88A 2du8B-3fk5A:
undetectable		 2du8B-3fk5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 12 ILE A 142
LEU A 137
ASN A   5
VAL A 191
VAL A 198
 None
 0.96A 2nnhA-3fk5A:
undetectable		 2nnhA-3fk5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		6 / 12 GLY A 129
THR A  89
VAL A  87
PHE A 117
ASP A 131
ILE A 132
 None
 1.32A 3elwA-3fk5A:
undetectable		 3elwA-3fk5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		6 / 12 GLY A 207
GLY A 129
VAL A  87
PHE A 117
ASP A 131
ILE A 132
 None
 1.16A 3elwA-3fk5A:
undetectable		 3elwA-3fk5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 12 MET A 190
GLY A 206
ARG A 135
ILE A 127
ASN A 128
 None
 1.45A 3jb2A-3fk5A:
undetectable		 3jb2A-3fk5A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 12 LEU A 108
ILE A  78
ILE A  83
ASP A  75
ALA A  72
 None
 1.14A 3uj7B-3fk5A:
undetectable		 3uj7B-3fk5A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 9 ALA A 255
ARG A 249
GLY A 253
LEU A 259
LEU A 252
 None
 1.39A 3wdmA-3fk5A:
undetectable		 3wdmA-3fk5A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 11 PHE A 126
ASN A 121
GLY A 129
ALA A 187
GLY A 150
 None
 1.27A 4a6nA-3fk5A:
undetectable		 4a6nA-3fk5A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 9 ALA A 212
ALA A 241
ILE A 238
GLY A 237
ILE A 325
 None
 1.00A 4eatB-3fk5A:
undetectable		 4eatB-3fk5A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		4 / 8 THR A  66
THR A 116
LEU A 108
VAL A 110
 None
 1.14A 4l4eA-3fk5A:
undetectable		 4l4eA-3fk5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		4 / 8 THR A  66
THR A 116
LEU A 108
VAL A 110
 None
 1.15A 4l4fA-3fk5A:
undetectable		 4l4fA-3fk5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		4 / 6 ILE A  49
GLY A  44
ILE A  38
ILE A  25
 None
 0.73A 4o8fB-3fk5A:
undetectable		 4o8fB-3fk5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 12 ALA A 241
ILE A 264
ASN A 128
LEU A 124
GLY A 326
 None
 1.19A 4r38A-3fk5A:
undetectable		 4r38A-3fk5A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 12 ALA A 241
ILE A 264
ASN A 128
LEU A 124
GLY A 326
 None
 1.23A 4r38B-3fk5A:
undetectable		 4r38B-3fk5A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 11 ASP A 149
ALA A  69
VAL A 104
THR A 100
ASP A  94
 None
 1.12A 4uuuA-3fk5A:
undetectable
4uuuB-3fk5A:
undetectable		 4uuuA-3fk5A:
18.53
4uuuB-3fk5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 11 ASP A 149
ALA A  69
VAL A 104
THR A 100
ASP A  94
 None
 1.13A 4uuuB-3fk5A:
undetectable		 4uuuB-3fk5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 12 LEU A 137
ALA A  76
VAL A 198
ALA A 201
ILE A  78
 None
 0.91A 4x20B-3fk5A:
undetectable		 4x20B-3fk5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		4 / 8 SER A 300
ALA A 299
HIS A 265
LEU A 183
 None
 1.06A 5dzkd-3fk5A:
undetectable
5dzkr-3fk5A:
undetectable		 5dzkd-3fk5A:
21.83
5dzkr-3fk5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		4 / 8 SER A 300
ALA A 299
HIS A 265
LEU A 183
 None
 1.05A 5dzkF-3fk5A:
undetectable
5dzkT-3fk5A:
undetectable		 5dzkF-3fk5A:
21.83
5dzkT-3fk5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		5 / 12 ILE A 127
GLY A 129
ALA A 299
ILE A   8
MET A 192
 None
 1.18A 5igyA-3fk5A:
undetectable		 5igyA-3fk5A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		6 / 12 VAL A 198
LEU A  11
MET A 190
VAL A 191
GLY A  10
ALA A  76
 None
 1.48A 5iktA-3fk5A:
undetectable		 5iktA-3fk5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		4 / 8 LEU A 305
ALA A 201
VAL A 263
TYR A 204
 None
 1.03A 5nu7A-3fk5A:
undetectable		 5nu7A-3fk5A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		4 / 7 ALA A 179
THR A 182
ILE A  49
LEU A  43
 None
 0.87A 5te8A-3fk5A:
undetectable		 5te8A-3fk5A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3fk5 3-OXOACYL-SYNTHASE
III
(Xanthomonas
oryzae) 		4 / 4 PHE A 126
LEU A 308
LEU A  11
VAL A 263
 None
 1.29A 5xxiA-3fk5A:
undetectable		 5xxiA-3fk5A:
21.75