SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fkf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3fkf THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 10 ALA A 126
LEU A 117
LEU A  55
GLU A  51
GLU A 132
 None
 1.44A 1a29A-3fkfA:
undetectable		 1a29A-3fkfA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 3fkf THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		4 / 7 GLU A  51
LEU A  34
TYR A  59
ILE A 129
 None
 1.05A 1tuvA-3fkfA:
undetectable		 1tuvA-3fkfA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3fkf THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		4 / 5 LYS A 139
LEU A 138
GLU A  58
LEU A  55
 None
 1.23A 4k4yA-3fkfA:
undetectable		 4k4yA-3fkfA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3fkf THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		4 / 4 LYS A 139
LEU A 138
GLU A  58
LEU A  55
 None
 1.24A 4k4yE-3fkfA:
undetectable		 4k4yE-3fkfA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3fkf THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		4 / 5 LYS A 139
LEU A 138
GLU A  58
LEU A  55
 None
 1.25A 4k4yI-3fkfA:
undetectable		 4k4yI-3fkfA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3fkf THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 11 LEU A 112
GLY A  69
LEU A  68
LEU A  72
ALA A 104
 None
 1.21A 4wnuA-3fkfA:
undetectable		 4wnuA-3fkfA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3fkf THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 11 ILE A  70
LEU A  88
LEU A 112
PHE A  37
ASN A 115
 None
 1.18A 6r2eG-3fkfA:
undetectable		 6r2eG-3fkfA:
20.68