SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		5 / 12 THR A 130
PRO A 132
VAL A 287
ILE A 266
LEU A 257
 None
 1.32A 1z9hA-3fkqA:
2.0		 1z9hA-3fkqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		5 / 12 THR A 130
PRO A 132
VAL A 287
ILE A 266
LEU A 257
 None
 1.32A 1z9hB-3fkqA:
2.0		 1z9hB-3fkqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		5 / 12 THR A 130
PRO A 132
VAL A 287
ILE A 266
LEU A 257
 None
 1.32A 1z9hC-3fkqA:
undetectable		 1z9hC-3fkqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		3 / 3 ASP A 181
ASP A 219
ASN A 176
 None
 0.84A 2bm9D-3fkqA:
undetectable		 2bm9D-3fkqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		4 / 6 SER A 124
PHE A 157
ILE A 201
PHE A 211
 None
 1.27A 2qeiA-3fkqA:
undetectable		 2qeiA-3fkqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		4 / 7 ILE A 245
THR A 166
ILE A 352
GLY A 137
 None
None
None
ATP  A 500 (-3.2A)
 0.62A 2v0mB-3fkqA:
undetectable		 2v0mB-3fkqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		4 / 8 ILE A 325
GLY A 326
LEU A 343
PHE A 129
 None
 0.68A 2vctB-3fkqA:
undetectable		 2vctB-3fkqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		4 / 7 ILE A 325
GLY A 326
LEU A 343
PHE A 129
 None
 0.67A 2vctD-3fkqA:
undetectable		 2vctD-3fkqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		4 / 7 VAL A 268
THR A 130
ILE A 266
ILE A 298
 None
 0.88A 3deuA-3fkqA:
undetectable		 3deuA-3fkqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		5 / 10 LEU A  30
VAL A   5
ILE A  99
LEU A  18
ILE A  54
 None
 1.05A 3jw3A-3fkqA:
3.6		 3jw3A-3fkqA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		5 / 10 ASP A  51
VAL A   5
CYH A  70
GLY A  71
ALA A  73
 None
 1.21A 3ucjA-3fkqA:
undetectable		 3ucjA-3fkqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		5 / 10 ASP A  51
VAL A   5
CYH A  70
GLY A  71
ALA A  73
 None
 1.18A 3ucjB-3fkqA:
undetectable		 3ucjB-3fkqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		5 / 7 LEU A 195
ASN A 192
ALA A 191
VAL A 106
ILE A  81
 None
 1.39A 4eyrA-3fkqA:
undetectable		 4eyrA-3fkqA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		3 / 3 GLU A  87
ASP A  86
ASP A  62
 None
 0.52A 4gc9A-3fkqA:
undetectable		 4gc9A-3fkqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		5 / 12 LEU A  72
LEU A   8
ALA A  55
ILE A  42
ALA A  41
 None
 1.07A 5xiwD-3fkqA:
2.7		 5xiwD-3fkqA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		5 / 11 ALA A 177
ASP A 219
SER A 180
VAL A 246
ILE A 161
 None
 1.20A 5y80A-3fkqA:
undetectable		 5y80A-3fkqA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		5 / 11 ALA A 177
ASP A 219
SER A 180
VAL A 246
ILE A 228
 None
 1.03A 5y80A-3fkqA:
undetectable		 5y80A-3fkqA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		5 / 12 PHE A 129
ILE A 352
HIS A 149
ALA A 144
LEU A 343
 None
 1.42A 5zwrB-3fkqA:
undetectable		 5zwrB-3fkqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN
([Eubacterium]
rectale) 		4 / 6 LEU A 290
TYR A 225
GLN A 163
GLU A 253
 None
 1.50A 6djzC-3fkqA:
undetectable		 6djzC-3fkqA:
18.98