SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fkr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE
(Azospirillum
brasilense) 		5 / 10 GLY A 222
ASP A 208
ILE A 183
GLY A 205
ALA A 165
 None
None
KPI  A 182 ( 3.8A)
None
None
 0.95A 1sh9B-3fkrA:
undetectable		 1sh9B-3fkrA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE
(Azospirillum
brasilense) 		5 / 10 ARG A 309
ALA A 308
LEU A 304
LEU A 277
VAL A 315
 None
 1.03A 2bxgB-3fkrA:
undetectable		 2bxgB-3fkrA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE
(Azospirillum
brasilense) 		4 / 6 ALA A 172
ILE A 151
VAL A 153
PHE A 181
 None
 0.96A 2cizA-3fkrA:
undetectable		 2cizA-3fkrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE
(Azospirillum
brasilense) 		4 / 5 GLN A 111
ALA A 148
GLN A 177
ILE A 147
 None
 1.47A 2z0aA-3fkrA:
undetectable		 2z0aA-3fkrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE
(Azospirillum
brasilense) 		3 / 3 PRO A  28
THR A  29
LEU A  60
 None
 0.79A 3ttrA-3fkrA:
undetectable		 3ttrA-3fkrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE
(Azospirillum
brasilense) 		4 / 5 LEU A  57
PRO A  28
VAL A  27
ASP A  47
 None
 0.77A 3ufnA-3fkrA:
undetectable
3ufnB-3fkrA:
undetectable		 3ufnA-3fkrA:
17.79
3ufnB-3fkrA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE
(Azospirillum
brasilense) 		4 / 5 LEU A 168
LEU A 163
MET A 121
THR A 185
 None
 1.39A 4do3A-3fkrA:
undetectable		 4do3A-3fkrA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE
(Azospirillum
brasilense) 		4 / 5 GLU A 210
ALA A 156
GLU A 184
GLU A 211
 PO4  A 404 (-4.6A)
None
NA  A 409 ( 2.1A)
NA  A 409 ( 4.9A)
 1.30A 5dwkC-3fkrA:
undetectable		 5dwkC-3fkrA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE
(Azospirillum
brasilense) 		5 / 12 ASP A 208
ALA A 226
ASP A 234
GLY A 230
GLU A 211
 None
None
None
None
NA  A 409 ( 4.9A)
 1.09A 5hfjD-3fkrA:
undetectable		 5hfjD-3fkrA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE
(Azospirillum
brasilense) 		4 / 7 THR A  34
ARG A 288
PHE A  31
LEU A  37
 None
PO4  A 405 (-3.9A)
None
None
 1.25A 5uxcA-3fkrA:
undetectable		 5uxcA-3fkrA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE
(Azospirillum
brasilense) 		4 / 6 MET A 152
GLU A 184
GLY A 225
GLY A  22
 KPI  A 182 ( 3.9A)
NA  A 409 ( 2.1A)
None
None
 0.92A 5x7pB-3fkrA:
undetectable		 5x7pB-3fkrA:
12.47