SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3fky GLUTAMINE SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 285
THR A 351
LEU A 117
MET A 361
 None
 1.43A 1uw6G-3fkyA:
undetectable
1uw6H-3fkyA:
undetectable		 1uw6G-3fkyA:
18.80
1uw6H-3fkyA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fky GLUTAMINE SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  35
THR A  34
ILE A  74
CYH A  98
PHE A  59
 None
 1.36A 2akeA-3fkyA:
undetectable		 2akeA-3fkyA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fky GLUTAMINE SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  35
THR A  34
ILE A  74
CYH A  98
PHE A  59
 None
 1.34A 2azxA-3fkyA:
undetectable		 2azxA-3fkyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fky GLUTAMINE SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A  35
THR A  34
ILE A  74
CYH A  98
PHE A  59
 None
 1.35A 2dr2A-3fkyA:
undetectable		 2dr2A-3fkyA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3fky GLUTAMINE SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  46
SER A  50
GLN A  53
 None
 0.98A 3si7A-3fkyA:
undetectable		 3si7A-3fkyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3fky GLUTAMINE SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 SER A 197
TYR A 168
VAL A 143
TRP A 244
 None
 1.14A 4l64A-3fkyA:
undetectable		 4l64A-3fkyA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3fky GLUTAMINE SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A  32
TYR A 342
PRO A 341
LEU A 343
 None
 1.28A 5bmvB-3fkyA:
undetectable		 5bmvB-3fkyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3fky GLUTAMINE SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 109
ASP A 213
GLY A 212
 None
 0.64A 5fctB-3fkyA:
undetectable		 5fctB-3fkyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 3fky GLUTAMINE SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 339
GLN A 132
CYH A 249
GLU A 133
 None
None
None
FLC  A 371 (-3.2A)
 1.27A 5fseC-3fkyA:
0.0		 5fseC-3fkyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMW_A_PNNA305_0
(BETA-LACTAMASE
TOHO-1)		 3fky GLUTAMINE SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 338
PRO A 237
ASN A 289
ASP A 290
 None
 1.29A 5kmwA-3fkyA:
0.0		 5kmwA-3fkyA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3fky GLUTAMINE SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 117
PHE A 118
ASP A 213
PHE A 128
ILE A  31
 None
 1.29A 6dwnA-3fkyA:
undetectable		 6dwnA-3fkyA:
14.63