SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GXS_A_BEZA601_0 (P-(S)-HYDROXYMANDELO NITRILE LYASE CHAIN A P-(S)-HYDROXYMANDELO NITRILE LYASE CHAIN B)	3fl7	EPHRIN RECEPTOR (Homo sapiens)	4 / 7	GLY A 75 ASP A 184 SER A 74 ALA A 187	None	1.00A	1gxsA-3fl7A: undetectable 1gxsB-3fl7A: undetectable	1gxsA-3fl7A: 18.32 1gxsB-3fl7A: 14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L64_A_C2FA802_0 (5-METHYLTETRAHYDROPT EROYLTRIGLUTAMATE--H OMOCYSTEINE METHYLTRANSFERASE)	3fl7	EPHRIN RECEPTOR (Homo sapiens)	4 / 7	TRP A 456 TYR A 473 ARG A 485 VAL A 454	None	1.46A	4l64A-3fl7A: undetectable	4l64A-3fl7A: 22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AOX_C_ACTC1001_0 (ALU JO CONSENSUS RNA SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN)	3fl7	EPHRIN RECEPTOR (Homo sapiens)	3 / 3	TYR A 334 THR A 336 THR A 349	None	0.59A	5aoxB-3fl7A: undetectable	5aoxB-3fl7A: 10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AOX_F_ACTF1001_0 (ALU JO CONSENSUS RNA SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN)	3fl7	EPHRIN RECEPTOR (Homo sapiens)	3 / 3	TYR A 334 THR A 336 THR A 349	None	0.64A	5aoxE-3fl7A: undetectable	5aoxE-3fl7A: 10.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GXS_A_BEZA601_0","P-(S)-HYDROXYMANDELONITRILE LYASE CHAIN A;P-(S)-HYDROXYMANDELONITRILE LYASE CHAIN B","3fl7","EPHRIN RECEPTOR","Homo sapiens",4,"GLY A  75;ASP A 184;SER A  74;ALA A 187","None","1.00A","1gxsA-3fl7A:undetectable;1gxsB-3fl7A:undetectable","1gxsA-3fl7A:18.32;1gxsB-3fl7A:14.77"],["4L64_A_C2FA802_0","5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE","3fl7","EPHRIN RECEPTOR","Homo sapiens",4,"TRP A 456;TYR A 473;ARG A 485;VAL A 454","None","1.46A","4l64A-3fl7A:undetectable","4l64A-3fl7A:22.65"],["5AOX_C_ACTC1001_0","ALU JO CONSENSUS RNA;SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN","3fl7","EPHRIN RECEPTOR","Homo sapiens",3,"TYR A 334;THR A 336;THR A 349","None","0.59A","5aoxB-3fl7A:undetectable","5aoxB-3fl7A:10.56"],["5AOX_F_ACTF1001_0","ALU JO CONSENSUS RNA;SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN","3fl7","EPHRIN RECEPTOR","Homo sapiens",3,"TYR A 334;THR A 336;THR A 349","None","0.64A","5aoxE-3fl7A:undetectable","5aoxE-3fl7A:10.56"]]