SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3flb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 3flb RIFR
(Amycolatopsis
mediterranei) 		5 / 12 ALA A  94
MET A  95
GLY A  92
PHE A  91
PHE A 229
 CL  A 268 (-3.5A)
None
None
None
None
 1.14A 1brpA-3flbA:
undetectable		 1brpA-3flbA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 5 TYR A  54
ILE A  69
ARG A  57
GLY A  30
 None
 1.16A 1kifA-3flbA:
undetectable		 1kifA-3flbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 5 TYR A  54
ILE A  69
ARG A  57
GLY A  30
 None
 1.16A 1kifB-3flbA:
undetectable		 1kifB-3flbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 5 TYR A  54
ILE A  69
ARG A  57
GLY A  30
 None
 1.16A 1kifC-3flbA:
undetectable		 1kifC-3flbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 5 TYR A  54
ILE A  69
ARG A  57
GLY A  30
 None
 1.16A 1kifD-3flbA:
undetectable		 1kifD-3flbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 5 TYR A  54
ILE A  69
ARG A  57
GLY A  30
 None
 1.16A 1kifE-3flbA:
undetectable		 1kifE-3flbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 5 TYR A  54
ILE A  69
ARG A  57
GLY A  30
 None
 1.16A 1kifF-3flbA:
undetectable		 1kifF-3flbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 5 TYR A  54
ILE A  69
ARG A  57
GLY A  30
 None
 1.16A 1kifG-3flbA:
undetectable		 1kifG-3flbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 5 TYR A  54
ILE A  69
ARG A  57
GLY A  30
 None
 1.16A 1kifH-3flbA:
undetectable		 1kifH-3flbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3flb RIFR
(Amycolatopsis
mediterranei) 		5 / 12 LEU A 146
HIS A 228
ARG A 202
ILE A 170
TYR A  54
 None
 1.27A 1ot7B-3flbA:
undetectable		 1ot7B-3flbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 7 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.09A 1rxcD-3flbA:
3.6		 1rxcD-3flbA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 7 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.04A 1rxcF-3flbA:
undetectable		 1rxcF-3flbA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 7 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.07A 1rxcL-3flbA:
3.3		 1rxcL-3flbA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 8 GLU A 178
VAL A 134
GLU A 207
ASP A 132
 None
 1.12A 1s3zA-3flbA:
undetectable
1s3zB-3flbA:
undetectable		 1s3zA-3flbA:
19.85
1s3zB-3flbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 5 TYR A  54
ILE A  69
ARG A  57
GLY A  30
 None
 1.20A 1ve9A-3flbA:
undetectable		 1ve9A-3flbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3flb RIFR
(Amycolatopsis
mediterranei) 		5 / 12 ALA A  89
GLY A  96
GLY A 100
LEU A  72
ASP A 173
 None
 1.13A 1x1aA-3flbA:
undetectable		 1x1aA-3flbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 5 TYR A  54
ILE A  69
ARG A  57
GLY A  30
 None
 1.16A 2du8J-3flbA:
undetectable		 2du8J-3flbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2001_1
(SERUM ALBUMIN)		 3flb RIFR
(Amycolatopsis
mediterranei) 		5 / 12 ARG A 186
ILE A  99
TYR A 180
ARG A 106
GLY A  71
 None
 1.48A 2vufB-3flbA:
undetectable		 2vufB-3flbA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 3flb RIFR
(Amycolatopsis
mediterranei) 		3 / 3 SER A  34
ARG A  11
GLN A  53
 None
 0.86A 2xnrA-3flbA:
undetectable		 2xnrA-3flbA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 8 TYR A 180
HIS A 214
GLY A 100
ILE A  98
 None
 0.90A 2zm9A-3flbA:
undetectable		 2zm9A-3flbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 3flb RIFR
(Amycolatopsis
mediterranei) 		5 / 12 GLY A  31
PHE A  13
LEU A 146
ASP A 153
ALA A 154
 None
 1.28A 3d91A-3flbA:
undetectable		 3d91A-3flbA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 6 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.07A 3kvvA-3flbA:
undetectable		 3kvvA-3flbA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 6 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.07A 3kvvB-3flbA:
undetectable		 3kvvB-3flbA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 6 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.08A 3kvvC-3flbA:
2.5		 3kvvC-3flbA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 6 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.09A 3kvvD-3flbA:
undetectable		 3kvvD-3flbA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 6 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.09A 3kvvE-3flbA:
undetectable		 3kvvE-3flbA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 6 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.06A 3kvvF-3flbA:
2.9		 3kvvF-3flbA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 3flb RIFR
(Amycolatopsis
mediterranei) 		5 / 12 VAL A  24
LEU A  50
LEU A  26
VAL A  79
LEU A 103
 None
 1.07A 3pghD-3flbA:
undetectable		 3pghD-3flbA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 3flb RIFR
(Amycolatopsis
mediterranei) 		5 / 9 PHE A  91
PHE A  36
PHE A 195
ALA A 235
LEU A  43
 None
None
None
PG4  A5798 (-3.4A)
None
 1.38A 3t3sA-3flbA:
0.0		 3t3sA-3flbA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 7 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.07A 4e1vB-3flbA:
undetectable		 4e1vB-3flbA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 6 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.04A 4e1vF-3flbA:
3.6		 4e1vF-3flbA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 6 GLY A  70
GLY A  71
GLU A 102
ILE A  99
 None
 0.86A 4fglD-3flbA:
3.1		 4fglD-3flbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 6 GLY A  92
PRO A  27
TYR A  54
GLY A  30
 None
 0.88A 4fjpA-3flbA:
undetectable		 4fjpA-3flbA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 5 HIS A  28
ALA A  94
HIS A 228
TYR A 174
 None
CL  A 268 (-3.5A)
None
CL  A 268 ( 4.8A)
 1.41A 4gboB-3flbA:
undetectable		 4gboB-3flbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3flb RIFR
(Amycolatopsis
mediterranei) 		5 / 11 ALA A 155
GLY A  30
GLY A  31
SER A  32
SER A  34
 None
 0.87A 4qvwK-3flbA:
undetectable
4qvwL-3flbA:
undetectable		 4qvwK-3flbA:
21.11
4qvwL-3flbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3flb RIFR
(Amycolatopsis
mediterranei) 		5 / 11 ALA A 155
GLY A  30
GLY A  31
SER A  32
SER A  34
 None
 0.88A 4qvwY-3flbA:
undetectable
4qvwZ-3flbA:
undetectable		 4qvwY-3flbA:
21.11
4qvwZ-3flbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 6 GLU A  48
ARG A  15
ARG A  22
ASP A  18
 None
 1.27A 5zw4A-3flbA:
undetectable		 5zw4A-3flbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 8 ASP A 200
ARG A 202
GLU A 145
GLU A 178
 None
 0.98A 6mn4C-3flbA:
undetectable		 6mn4C-3flbA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 7 ASP A 200
ARG A 202
GLU A 145
GLU A 178
 None
 1.13A 6mn5B-3flbA:
undetectable		 6mn5B-3flbA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 6 ASP A 200
ARG A 202
GLU A 145
GLU A 178
 None
 1.07A 6mn5D-3flbA:
undetectable		 6mn5D-3flbA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3flb RIFR
(Amycolatopsis
mediterranei) 		4 / 7 ASP A 200
ARG A 202
GLU A 145
GLU A 178
 None
 1.27A 6mn5E-3flbA:
undetectable		 6mn5E-3flbA:
15.35