SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		4 / 8 SER A  60
HIS A 269
SER A 270
HIS A 273
 None
 1.11A 1eqbA-3fleA:
undetectable
1eqbB-3fleA:
undetectable		 1eqbA-3fleA:
20.10
1eqbB-3fleA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		4 / 8 SER A  60
HIS A 269
SER A 270
HIS A 273
 None
 1.12A 1eqbA-3fleA:
undetectable
1eqbB-3fleA:
undetectable		 1eqbA-3fleA:
20.10
1eqbB-3fleA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		4 / 8 SER A  60
HIS A 269
SER A 270
HIS A 273
 None
 1.12A 1eqbC-3fleA:
undetectable
1eqbD-3fleA:
undetectable		 1eqbC-3fleA:
20.10
1eqbD-3fleA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		4 / 8 SER A  60
HIS A 269
SER A 270
HIS A 273
 None
 1.13A 1eqbC-3fleA:
undetectable
1eqbD-3fleA:
undetectable		 1eqbC-3fleA:
20.10
1eqbD-3fleA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		4 / 8 SER A 253
LEU A 246
PHE A 138
PHE A 150
 None
 0.99A 1wrlC-3fleA:
undetectable
1wrlD-3fleA:
undetectable		 1wrlC-3fleA:
17.57
1wrlD-3fleA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		4 / 8 SER A  60
HIS A 269
SER A 270
HIS A 273
 None
 1.09A 2vmyA-3fleA:
undetectable
2vmyB-3fleA:
undetectable		 2vmyA-3fleA:
19.05
2vmyB-3fleA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		5 / 10 ILE A 172
GLY A 142
GLY A  53
HIS A 269
HIS A 273
 None
 1.35A 2y7pA-3fleA:
undetectable		 2y7pA-3fleA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		3 / 3 LEU A 126
TRP A 121
TYR A 157
 None
 0.96A 3aicB-3fleA:
undetectable		 3aicB-3fleA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		3 / 3 LEU A 126
TRP A 121
TYR A 157
 None
 0.95A 3aicE-3fleA:
undetectable		 3aicE-3fleA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		3 / 3 LEU A 126
TRP A 121
TYR A 157
 None
 0.99A 3aicG-3fleA:
undetectable		 3aicG-3fleA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		3 / 3 LEU A 126
TRP A 121
TYR A 157
 None
 0.93A 3aicH-3fleA:
undetectable		 3aicH-3fleA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 ASN A 139
ILE A 102
THR A  74
VAL A  77
ILE A  78
 None
 1.03A 3kpbA-3fleA:
undetectable		 3kpbA-3fleA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		5 / 10 ILE A 122
ALA A 151
PHE A 140
SER A 144
ILE A 172
 None
 1.20A 3qgtA-3fleA:
2.1		 3qgtA-3fleA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		4 / 7 ASN A 147
PHE A 150
ALA A 151
LEU A 250
 None
 0.86A 3t3sC-3fleA:
undetectable		 3t3sC-3fleA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 GLY A 195
ASP A 192
ILE A 190
ASN A 201
ASN A 183
 None
 0.93A 4a81A-3fleA:
undetectable		 4a81A-3fleA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 ASN A 118
GLY A 146
ASN A 147
PHE A 115
GLY A 174
 None
 1.22A 4n09A-3fleA:
3.6		 4n09A-3fleA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		3 / 3 PRO A 164
LEU A  94
SER A 127
 None
 0.82A 5fsaB-3fleA:
undetectable		 5fsaB-3fleA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 GLY A  56
GLY A 142
GLY A 146
VAL A 170
ILE A 172
 None
 0.92A 5njvC-3fleA:
undetectable		 5njvC-3fleA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 3fle SE_1780 PROTEIN
(Staphylococcus
epidermidis) 		3 / 3 GLY A 178
ASN A 183
ARG A 199
 None
 0.75A 5w7bD-3fleA:
undetectable		 5w7bD-3fleA:
15.73