SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3flj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD
(Ruegeria
pomeroyi) 		4 / 5 PHE A  75
LEU A 114
VAL A  12
ASP A  88
 UNL  A 137 ( 4.4A)
None
UNL  A 137 (-4.7A)
UNL  A 137 (-2.7A)
 1.47A 1dz6A-3fljA:
undetectable		 1dz6A-3fljA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD
(Ruegeria
pomeroyi) 		5 / 12 ILE A   5
PHE A 101
ILE A  20
VAL A  11
ILE A  98
 None
 1.26A 1r5lA-3fljA:
undetectable		 1r5lA-3fljA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD
(Ruegeria
pomeroyi) 		5 / 12 VAL A  52
PHE A 101
ILE A  20
VAL A  11
ILE A  98
 UNL  A 137 ( 4.9A)
None
None
None
None
 1.35A 1r5lA-3fljA:
undetectable		 1r5lA-3fljA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD
(Ruegeria
pomeroyi) 		4 / 6 PHE A  59
PHE A  75
TYR A  61
VAL A  52
 UNL  A 137 (-4.5A)
UNL  A 137 ( 4.4A)
None
UNL  A 137 ( 4.9A)
 1.20A 3lb3A-3fljA:
undetectable		 3lb3A-3fljA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD
(Ruegeria
pomeroyi) 		4 / 6 PHE A  59
PHE A  75
TYR A  61
VAL A  52
 UNL  A 137 (-4.5A)
UNL  A 137 ( 4.4A)
None
UNL  A 137 ( 4.9A)
 1.22A 3lb3B-3fljA:
undetectable		 3lb3B-3fljA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD
(Ruegeria
pomeroyi) 		4 / 8 VAL A  87
TYR A  61
VAL A 103
ILE A  90
 None
 1.05A 4aftD-3fljA:
undetectable
4aftE-3fljA:
undetectable		 4aftD-3fljA:
22.12
4aftE-3fljA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD
(Ruegeria
pomeroyi) 		4 / 8 ALA A 120
PHE A  56
VAL A 103
PHE A  30
 None
 1.00A 4ltwA-3fljA:
undetectable		 4ltwA-3fljA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD
(Ruegeria
pomeroyi) 		3 / 3 LEU A  23
PHE A 101
ILE A  20
 None
 0.76A 5dzk1-3fljA:
undetectable
5dzkF-3fljA:
undetectable
5dzkM-3fljA:
undetectable		 5dzk1-3fljA:
4.65
5dzkF-3fljA:
22.75
5dzkM-3fljA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD
(Ruegeria
pomeroyi) 		4 / 8 ARG A 127
TRP A  39
VAL A 122
ASP A 125
 None
 1.00A 5vlmA-3fljA:
undetectable		 5vlmA-3fljA:
23.92