SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3flo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 MET A 250
SER A 493
ALA A 496
ILE B1338
 None
 1.16A 1gm7A-3floA:
undetectable
1gm7B-3floA:
undetectable		 1gm7A-3floA:
18.00
1gm7B-3floA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 8 SER A 304
SER A 315
ASN A 312
ASP A 308
 None
 1.17A 1hwkC-3floA:
undetectable		 1hwkC-3floA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 8 SER A 304
SER A 315
ASN A 312
ASP A 308
 None
 1.19A 1hwkD-3floA:
undetectable		 1hwkD-3floA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 407
HIS A 440
ALA A 404
GLY A 660
 None
 1.14A 1l5qA-3floA:
undetectable		 1l5qA-3floA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 407
HIS A 440
ALA A 404
GLY A 660
 None
 1.13A 1l5qB-3floA:
undetectable		 1l5qB-3floA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 407
HIS A 440
ALA A 404
GLY A 660
 None
 1.07A 1l7xA-3floA:
undetectable		 1l7xA-3floA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 407
HIS A 440
ALA A 404
GLY A 660
 None
 1.13A 1l7xB-3floA:
undetectable		 1l7xB-3floA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 MET A 250
SER A 493
ALA A 496
ILE B1338
 None
 1.10A 1pnlA-3floA:
undetectable
1pnlB-3floA:
undetectable		 1pnlA-3floA:
18.00
1pnlB-3floA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 ARG B1335
TYR B1448
LYS B1447
 None
 1.03A 1uujB-3floB:
undetectable		 1uujB-3floB:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 6 TYR B1410
ASP B1416
THR B1282
GLU B1284
 None
 1.37A 2dttB-3floB:
undetectable
2dttC-3floB:
undetectable		 2dttB-3floB:
15.46
2dttC-3floB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 ASP B1451
LEU B1449
ASN B1450
SER B1443
PHE B1392
 None
 1.17A 2ejtA-3floB:
undetectable		 2ejtA-3floB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 666
ILE A 632
ILE A 430
VAL A 648
ILE A 650
 None
 0.72A 2hs1B-3floA:
undetectable		 2hs1B-3floA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 521
HIS A 495
ASP A 611
TYR A 498
 None
 1.18A 2lh8A-3floA:
undetectable		 2lh8A-3floA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 531
VAL A 670
THR A 669
ILE A 526
 None
 0.97A 2qbmA-3floA:
undetectable		 2qbmA-3floA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 SER B1328
PRO B1323
GLY B1441
THR B1440
LEU B1395
 None
 0.90A 2zifA-3floB:
undetectable		 2zifA-3floB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 407
HIS A 440
ALA A 404
GLY A 660
 None
 1.14A 3dd1A-3floA:
undetectable		 3dd1A-3floA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 407
HIS A 440
ALA A 404
GLY A 660
 None
 1.15A 3ddwA-3floA:
undetectable		 3ddwA-3floA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 407
HIS A 440
ALA A 404
GLY A 660
 None
 1.14A 3ddwB-3floA:
undetectable		 3ddwB-3floA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 300
GLN A 346
VAL A 348
PHE A 342
 None
 1.50A 3ieoA-3floA:
undetectable		 3ieoA-3floA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 328
SER B1361
PHE B1363
ASP A 262
 None
 1.19A 3jq7B-3floA:
undetectable		 3jq7B-3floA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ARG A 328
SER B1361
PHE B1363
ASP A 262
 None
 1.17A 3jqaA-3floA:
undetectable		 3jqaA-3floA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ARG A 328
SER B1361
PHE B1363
ASP A 262
 None
 1.18A 3jqaB-3floA:
undetectable		 3jqaB-3floA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ARG A 328
SER B1361
PHE B1363
ASP A 262
 None
 1.21A 3jqaC-3floA:
undetectable		 3jqaC-3floA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ARG A 328
SER B1361
PHE B1363
ASP A 262
 None
 1.21A 3jqaD-3floA:
undetectable		 3jqaD-3floA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 396
THR A 398
ILE A 476
SER A 419
PRO A 426
 None
 1.07A 3kpdB-3floA:
undetectable		 3kpdB-3floA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 402
MET A 431
ASN A 535
ASP A 490
 None
None
SO4  A  48 ( 4.8A)
None
 1.49A 3lslG-3floA:
undetectable		 3lslG-3floA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 442
SER A 445
LEU A 448
PRO A 449
 None
 1.26A 3onnA-3floA:
undetectable		 3onnA-3floA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 5 GLY B1371
ASP B1370
ARG A 328
GLN B1359
 None
 1.05A 3qx3A-3floB:
undetectable		 3qx3A-3floB:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 634
GLY A 400
ASP A 437
PRO A 486
LEU A 503
 SO4  A  48 (-4.5A)
None
None
None
None
 1.12A 3v8vA-3floA:
undetectable		 3v8vA-3floA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 642
ILE A 650
VAL A 700
LEU A 702
 None
 1.06A 4em2A-3floA:
undetectable		 4em2A-3floA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 666
ILE A 632
ILE A 430
VAL A 648
ILE A 650
 None
 0.71A 4q1xB-3floA:
undetectable		 4q1xB-3floA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 666
ILE A 632
ILE A 430
VAL A 648
ILE A 650
 None
 0.76A 4q1yB-3floA:
undetectable		 4q1yB-3floA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 319
ARG A 329
GLN A 264
 None
 0.94A 4rtbA-3floA:
2.2		 4rtbA-3floA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 465
ILE A 417
PHE A 435
LEU A 484
LEU A 510
 None
 1.17A 4xumA-3floA:
undetectable		 4xumA-3floA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 667
HIS A 427
ILE A 396
ILE A 480
 None
 1.18A 5dnvA-3floA:
undetectable		 5dnvA-3floA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 410
LEU B1324
LEU A 448
PHE A 403
ALA A 491
 None
 1.38A 5ieoA-3floA:
undetectable		 5ieoA-3floA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 424
ARG A 654
PRO A 652
 None
SO4  A  48 (-4.1A)
None
 0.84A 5koxA-3floA:
undetectable		 5koxA-3floA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 641
PHE A 531
ILE A 430
VAL A 395
 None
 0.82A 5nujA-3floA:
undetectable		 5nujA-3floA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 8 SER A 341
HIS A 563
PHE A 343
GLN A 567
 SO4  A   3 ( 4.5A)
SO4  A   3 (-3.5A)
None
None
 1.47A 5u6nA-3floA:
undetectable		 5u6nA-3floA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 9 LEU A 461
THR A 460
ASP A 462
GLY B1441
ILE B1330
 None
 1.19A 6ebpA-3floA:
undetectable		 6ebpA-3floA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 LEU A 461
THR A 460
ASP A 462
GLY B1441
ILE B1330
 None
 1.17A 6ebpB-3floA:
undetectable		 6ebpB-3floA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 LEU A 461
THR A 460
ASP A 462
GLY B1441
ILE B1330
 None
 1.16A 6ebpC-3floA:
undetectable		 6ebpC-3floA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3flo DNA POLYMERASE ALPHA
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 436
ASP A 490
ILE A 492
PRO A 401
PHE A 469
 None
 1.33A 6fbpA-3floA:
undetectable
6fbpB-3floA:
undetectable		 6fbpA-3floA:
10.79
6fbpB-3floA:
10.79