SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3flt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3flt SAP-LIKE PENTRAXIN
(Limulus
polyphemus) 		4 / 4 ILE A 142
LEU A  34
VAL A 168
ILE A 194
 None
 0.91A 1fm6D-3fltA:
undetectable		 1fm6D-3fltA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 3flt SAP-LIKE PENTRAXIN
(Limulus
polyphemus) 		5 / 12 ILE A 194
ILE A   4
PHE A 201
VAL A 209
VAL A 207
 None
 1.10A 2ygnA-3fltA:
undetectable		 2ygnA-3fltA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3flt SAP-LIKE PENTRAXIN
(Limulus
polyphemus) 		5 / 12 ILE A 194
ILE A   4
PHE A 201
VAL A 209
VAL A 207
 None
 1.05A 2ygoA-3fltA:
undetectable		 2ygoA-3fltA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3flt SAP-LIKE PENTRAXIN
(Limulus
polyphemus) 		3 / 3 CYH A  53
PHE A  62
PHE A  51
 None
 0.74A 3cr5X-3fltA:
undetectable		 3cr5X-3fltA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3flt SAP-LIKE PENTRAXIN
(Limulus
polyphemus) 		5 / 11 GLY A 143
THR A  14
GLY A  13
PRO A  12
PRO A  20
 None
 1.34A 3t8nD-3fltA:
undetectable
3t8nF-3fltA:
undetectable		 3t8nD-3fltA:
16.74
3t8nF-3fltA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3flt SAP-LIKE PENTRAXIN
(Limulus
polyphemus) 		5 / 11 THR A  14
GLY A  13
PRO A  12
PRO A  20
GLY A 143
 None
 1.33A 3t8nD-3fltA:
undetectable
3t8nF-3fltA:
undetectable		 3t8nD-3fltA:
16.74
3t8nF-3fltA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3flt SAP-LIKE PENTRAXIN
(Limulus
polyphemus) 		3 / 3 TYR A  49
THR A  47
GLU A 154
 OPE  A 400 (-4.6A)
None
CA  A 303 (-2.7A)
 0.77A 4df3A-3fltA:
undetectable		 4df3A-3fltA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3flt SAP-LIKE PENTRAXIN
(Limulus
polyphemus) 		3 / 3 TYR A  49
THR A  47
GLU A 154
 OPE  A 400 (-4.6A)
None
CA  A 303 (-2.7A)
 0.74A 4df3B-3fltA:
undetectable		 4df3B-3fltA:
18.93