SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3flu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 VAL A 256
ARG A  70
HIS A  66
GLU A  33
 None
 1.07A 1s3zA-3fluA:
undetectable
1s3zB-3fluA:
undetectable		 1s3zA-3fluA:
19.60
1s3zB-3fluA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 3 GLU A 263
GLN A 278
ARG A 282
 None
 0.93A 2w3bB-3fluA:
undetectable		 2w3bB-3fluA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 7 ASP A  29
ARG A  70
VAL A  71
ILE A  39
 None
 1.14A 2yfbA-3fluA:
undetectable		 2yfbA-3fluA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 3 GLY A  35
ASP A  37
SER A   5
 None
 0.48A 3brfA-3fluA:
undetectable		 3brfA-3fluA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 3 GLU A  33
GLY A  35
THR A  36
 None
 0.56A 3iazA-3fluA:
undetectable		 3iazA-3fluA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 11 SER A  48
THR A  44
ALA A  79
GLY A  78
THR A  77
 GOL  A 298 (-2.9A)
SO4  A 294 (-3.6A)
None
GOL  A 298 ( 4.1A)
None
 1.33A 3mg0H-3fluA:
undetectable
3mg0I-3fluA:
undetectable		 3mg0H-3fluA:
22.22
3mg0I-3fluA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 ILE A 132
ALA A 152
LEU A 151
PRO A 178
 None
 0.73A 3ozwA-3fluA:
undetectable		 3ozwA-3fluA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 3 ASN A  34
TRP A  30
ASP A 216
 GOL  A 299 (-3.1A)
GOL  A 299 (-4.2A)
None
 1.09A 4a7tA-3fluA:
undetectable
4a7tF-3fluA:
undetectable		 4a7tA-3fluA:
20.20
4a7tF-3fluA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 ASN A 208
ALA A 207
LEU A 236
TYR A 240
 None
 0.90A 4jjkA-3fluA:
2.2		 4jjkA-3fluA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 GLY A 165
ALA A 163
PHE A 194
ILE A 167
ILE A 171
 None
SO4  A 293 ( 4.2A)
None
None
None
 1.12A 4uw0A-3fluA:
undetectable		 4uw0A-3fluA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 GLY A  46
ALA A 209
SER A 185
ILE A 203
TYR A 133
 None
None
None
SO4  A 294 (-4.6A)
SO4  A 294 ( 4.7A)
 1.14A 5igvA-3fluA:
undetectable		 5igvA-3fluA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 9 ILE A  28
VAL A   7
THR A  36
ASN A  34
 None
None
None
GOL  A 299 (-3.1A)
 1.01A 5lg3I-3fluA:
undetectable		 5lg3I-3fluA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 6 ALA A 220
GLN A 223
GLN A   3
ASP A  37
 None
 1.46A 5y9aA-3fluA:
undetectable		 5y9aA-3fluA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 VAL A 182
PRO A 211
PHE A 214
PRO A  72
ILE A  32
 None
GOL  A 299 (-3.4A)
None
None
None
 1.45A 6becA-3fluA:
undetectable
6becB-3fluA:
undetectable
6becC-3fluA:
undetectable		 6becA-3fluA:
19.86
6becB-3fluA:
19.86
6becC-3fluA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 6 ILE A  19
MET A  13
ASN A  14
ASP A  16
 None
None
GOL  A 301 (-4.5A)
None
 1.06A 6dhbA-3fluA:
undetectable		 6dhbA-3fluA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 5 LEU A 173
THR A 147
PRO A 136
ARG A 138
 None
None
None
SO4  A 293 (-4.0A)
 1.13A 6ew0B-3fluA:
undetectable		 6ew0B-3fluA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 5 LEU A 173
THR A 147
PRO A 136
ARG A 138
 None
None
None
SO4  A 293 (-4.0A)
 1.13A 6ew0D-3fluA:
undetectable		 6ew0D-3fluA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 5 LEU A 173
THR A 147
PRO A 136
ARG A 138
 None
None
None
SO4  A 293 (-4.0A)
 1.14A 6ew0H-3fluA:
undetectable		 6ew0H-3fluA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 5 LEU A 173
THR A 147
PRO A 136
ARG A 138
 None
None
None
SO4  A 293 (-4.0A)
 1.13A 6ew0I-3fluA:
undetectable		 6ew0I-3fluA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 3 THR A 242
ALA A 284
LYS A 286
 None
 0.65A 6fgcA-3fluA:
undetectable		 6fgcA-3fluA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 4 MET A 195
GLY A 199
HIS A 200
GLY A 201
 None
 1.00A 6fgdA-3fluA:
undetectable		 6fgdA-3fluA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3flu DIHYDRODIPICOLINATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 3 THR A 242
ALA A 284
LYS A 286
 None
 0.65A 6fgdA-3fluA:
undetectable		 6fgdA-3fluA:
23.11