SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fmb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD
(Bacteroides
fragilis) 		6 / 12 LEU A  59
GLY A  82
ALA A  81
PRO A  34
ILE A  43
ILE A  30
 SO4  A 100 ( 4.8A)
None
None
None
None
None
 1.45A 3s54A-3fmbA:
undetectable		 3s54A-3fmbA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD
(Bacteroides
fragilis) 		4 / 8 ILE A  43
LEU A  59
LYS A  83
GLY A  82
 None
SO4  A 100 ( 4.8A)
None
None
 0.92A 3selX-3fmbA:
undetectable		 3selX-3fmbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD
(Bacteroides
fragilis) 		3 / 3 ASP A  96
TRP A  55
SER A  61
 None
 0.81A 4lrhA-3fmbA:
undetectable		 4lrhA-3fmbA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD
(Bacteroides
fragilis) 		4 / 7 PHE A   8
ILE A  57
GLY A  82
LEU A  33
 None
 0.65A 4zdzA-3fmbA:
2.2		 4zdzA-3fmbA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD
(Bacteroides
fragilis) 		4 / 7 PHE A   8
ILE A  57
GLY A  82
LEU A  33
 None
 0.73A 4ze3A-3fmbA:
undetectable		 4ze3A-3fmbA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD
(Bacteroides
fragilis) 		4 / 8 PHE A   8
ILE A  57
GLY A  82
LEU A  33
 None
 0.66A 5esfA-3fmbA:
undetectable		 5esfA-3fmbA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD
(Bacteroides
fragilis) 		4 / 8 PHE A   8
ILE A  57
GLY A  82
LEU A  33
 None
 0.71A 5esjA-3fmbA:
undetectable		 5esjA-3fmbA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD
(Bacteroides
fragilis) 		4 / 7 PHE A   8
ILE A  57
GLY A  82
LEU A  33
 None
 0.65A 5esmA-3fmbA:
undetectable		 5esmA-3fmbA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD
(Bacteroides
fragilis) 		4 / 8 PHE A   8
ILE A  57
GLY A  82
LEU A  33
 None
 0.69A 5hs1A-3fmbA:
undetectable		 5hs1A-3fmbA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD
(Bacteroides
fragilis) 		5 / 12 HIS A  78
SER A  61
ARG A  41
PRO A  34
ILE A  43
 SO4  A 100 (-4.0A)
None
None
None
None
 1.35A 5uacC-3fmbA:
0.0		 5uacC-3fmbA:
6.05