SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		5 / 10 ASP A 169
HIS A 171
LEU A 157
ILE A  79
ASN A  75
 None
 1.24A 1sq5B-3fmcA:
0.6		 1sq5B-3fmcA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		3 / 3 ASN A  75
TRP A  99
GLN A  38
 None
 1.08A 1xoqA-3fmcA:
undetectable		 1xoqA-3fmcA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		5 / 12 GLN A 191
ALA A 189
PRO A 276
GLY A 259
LEU A 261
 None
 1.35A 2nv4A-3fmcA:
undetectable		 2nv4A-3fmcA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		3 / 3 PRO A 342
GLY A 304
TYR A 358
 None
 0.57A 2vouA-3fmcA:
undetectable		 2vouA-3fmcA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		3 / 3 PRO A 342
GLY A 304
TYR A 358
 None
 0.58A 2vouB-3fmcA:
undetectable		 2vouB-3fmcA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		3 / 3 PRO A 342
GLY A 304
TYR A 358
 None
 0.58A 2vouC-3fmcA:
2.1		 2vouC-3fmcA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		4 / 8 THR A 239
TYR A 181
ILE A 201
ASP A 169
 None
 0.84A 2xytE-3fmcA:
undetectable		 2xytE-3fmcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		4 / 7 ASP A 169
HIS A 171
LEU A 157
ILE A  79
 None
 0.84A 3avpA-3fmcA:
undetectable		 3avpA-3fmcA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		5 / 12 GLY A  48
GLN A  47
VAL A  46
LEU A 250
ILE A  79
 None
 1.24A 3h52B-3fmcA:
undetectable		 3h52B-3fmcA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		5 / 12 LEU A  64
GLY A 268
GLY A  32
ILE A 166
ALA A 271
 None
 1.15A 4a6dA-3fmcA:
undetectable		 4a6dA-3fmcA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		5 / 12 ILE A  68
LEU A 170
ALA A 257
LEU A 261
LEU A 264
 None
 1.01A 4m11B-3fmcA:
undetectable		 4m11B-3fmcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		5 / 9 LEU A 357
HIS A 345
VAL A 351
SER A 350
VAL A 300
 None
 0.99A 4qd3A-3fmcA:
2.7		 4qd3A-3fmcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		5 / 12 VAL A   8
GLN A  38
ILE A  52
ASN A  49
TYR A  36
 None
 1.33A 4s0vA-3fmcA:
2.7		 4s0vA-3fmcA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		4 / 6 TYR A 289
LYS A 359
GLY A 173
SER A 176
 None
 1.26A 5bphA-3fmcA:
2.5		 5bphA-3fmcA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		4 / 7 TYR A 289
LYS A 359
GLY A 173
SER A 176
 None
 1.17A 5bphB-3fmcA:
2.1		 5bphB-3fmcA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		4 / 6 TYR A 289
LYS A 359
GLY A 173
SER A 176
 None
 1.30A 5bphD-3fmcA:
1.8		 5bphD-3fmcA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		5 / 12 PHE A 193
LEU A 238
ALA A 189
ILE A 166
LEU A  55
 None
 1.10A 5h8tA-3fmcA:
undetectable		 5h8tA-3fmcA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		5 / 12 PHE A 193
LEU A 238
ALA A 189
ILE A 166
LEU A  55
 None
 1.05A 5ljeA-3fmcA:
undetectable		 5ljeA-3fmcA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		3 / 3 HIS A 117
GLU A 116
TRP A 113
 None
 0.91A 5odiD-3fmcA:
3.3		 5odiD-3fmcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		3 / 3 HIS A 117
GLU A 116
TRP A 113
 None
 0.95A 5odqD-3fmcA:
3.2		 5odqD-3fmcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		3 / 3 HIS A 117
GLU A 116
TRP A 113
 None
 0.88A 5odrD-3fmcA:
3.3		 5odrD-3fmcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		3 / 3 THR A 239
GLU A 241
HIS A  42
 None
SO4  A 368 ( 4.7A)
SO4  A 368 (-4.4A)
 0.91A 5xioA-3fmcA:
undetectable		 5xioA-3fmcA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE
(Shewanella
amazonensis) 		5 / 12 VAL A  41
LEU A 153
GLU A  45
LEU A  21
LEU A 157
 None
 1.07A 6f6iA-3fmcA:
undetectable
6f6iB-3fmcA:
undetectable		 6f6iA-3fmcA:
13.57
6f6iB-3fmcA:
13.76