SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FMO_E_ADNE351_1 (CAMP-DEPENDENT PROTEIN KINASE)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	7 / 12	LEU A 59 GLY A 60 VAL A 67 ALA A 80 VAL A 113 ASN A 184 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None STU A 1 (-3.4A) None STU A 1 ( 4.9A) STU A 1 (-4.4A)	0.56A	1fmoE-3fmeA: 22.4	1fmoE-3fmeA: 26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK2_A_T44A3004_1 (SERUM ALBUMIN)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 7	PHE A 313 ALA A 159 LEU A 155 MET A 247	None	0.95A	1hk2A-3fmeA: undetectable	1hk2A-3fmeA: 19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IEP_A_STIA201_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LYS A 82 VAL A 113 ILE A 127 MET A 132	STU A 1 ( 4.2A) None None None	0.67A	1iepA-3fmeA: 17.7	1iepA-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IEP_B_STIB202_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 7	LYS A 82 ILE A 127 MET A 132 LEU A 186	STU A 1 ( 4.2A) None None STU A 1 (-4.4A)	0.73A	1iepB-3fmeA: 17.6	1iepB-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IEP_B_STIB202_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 7	LYS A 82 VAL A 113 ILE A 127 LEU A 186	STU A 1 ( 4.2A) None None STU A 1 (-4.4A)	0.76A	1iepB-3fmeA: 17.6	1iepB-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OPJ_B_STIB4_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LEU A 59 LYS A 82 ILE A 127 MET A 132	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None	0.52A	1opjB-3fmeA: 17.0	1opjB-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SV9_A_DIFA701_1 (PHOSPHOLIPASE A2)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 8	LEU A 308 ALA A 159 ILE A 162 GLY A 244 PHE A 287	None	1.12A	1sv9A-3fmeA: undetectable	1sv9A-3fmeA: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B17_A_DIFA701_1 (PHOSPHOLIPASE A2 VRV-PL-VIIIA)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 10	LEU A 308 ALA A 159 ILE A 162 GLY A 244 PHE A 287	None	1.14A	2b17A-3fmeA: undetectable	2b17A-3fmeA: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EVA_A_ADNA498_1 (TAK1 KINASE - TAB1 CHIMERA FUSION PROTEIN)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 11	GLY A 60 VAL A 67 ALA A 80 MET A 129 SER A 135 LEU A 186	STU A 1 (-3.5A) None STU A 1 (-3.4A) STU A 1 ( 3.8A) STU A 1 (-3.2A) STU A 1 (-4.4A)	0.61A	2evaA-3fmeA: 18.8	2evaA-3fmeA: 28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_A_MIXA539_1 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	7 / 12	LEU A 59 GLY A 60 VAL A 67 ALA A 80 ASP A 179 LYS A 181 ASN A 184	STU A 1 (-3.8A) STU A 1 (-3.5A) None STU A 1 (-3.4A) None None STU A 1 ( 4.9A)	0.58A	2fumA-3fmeA: 20.0	2fumA-3fmeA: 28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_B_MIXB1539_1 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	7 / 12	LEU A 59 GLY A 60 VAL A 67 ALA A 80 MET A 129 LYS A 181 ASN A 184	STU A 1 (-3.8A) STU A 1 (-3.5A) None STU A 1 (-3.4A) STU A 1 ( 3.8A) None STU A 1 ( 4.9A)	0.63A	2fumB-3fmeA: 23.5	2fumB-3fmeA: 28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_C_MIXC2539_1 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 12	LEU A 59 GLY A 60 VAL A 67 ALA A 80 MET A 129 ASN A 184	STU A 1 (-3.8A) STU A 1 (-3.5A) None STU A 1 (-3.4A) STU A 1 ( 3.8A) STU A 1 ( 4.9A)	0.59A	2fumC-3fmeA: 23.8	2fumC-3fmeA: 28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_D_MIXD3539_1 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	7 / 12	LEU A 59 GLY A 60 GLY A 62 VAL A 67 ALA A 80 MET A 129 ASN A 184	STU A 1 (-3.8A) STU A 1 (-3.5A) None None STU A 1 (-3.4A) STU A 1 ( 3.8A) STU A 1 ( 4.9A)	0.53A	2fumD-3fmeA: 20.8	2fumD-3fmeA: 28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HYY_A_STIA600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LEU A 59 LYS A 82 VAL A 113 ILE A 127	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None	0.46A	2hyyA-3fmeA: 17.7	2hyyA-3fmeA: 27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HYY_B_STIB600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LEU A 59 LYS A 82 ILE A 127 MET A 132	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None	0.52A	2hyyB-3fmeA: 17.6	2hyyB-3fmeA: 27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HYY_B_STIB600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LEU A 59 LYS A 82 VAL A 113 ILE A 127	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None	0.52A	2hyyB-3fmeA: 17.6	2hyyB-3fmeA: 27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HYY_C_STIC600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LEU A 59 LYS A 82 ILE A 127 MET A 132	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None	0.50A	2hyyC-3fmeA: 17.3	2hyyC-3fmeA: 27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HYY_D_STID600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 4	LEU A 59 LYS A 82 VAL A 113 MET A 132	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None	0.61A	2hyyD-3fmeA: 17.5	2hyyD-3fmeA: 27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PRG_A_BRLA1_2 (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	3 / 3	ILE A 154 ILE A 187 LEU A 278	None	0.53A	2prgA-3fmeA: undetectable	2prgA-3fmeA: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AOX_A_EMHA901_1 (ALK TYROSINE KINASE RECEPTOR)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 10	LEU A 59 ALA A 80 VAL A 113 LEU A 131 MET A 132 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.4A) None STU A 1 (-4.6A) None STU A 1 (-4.4A)	0.72A	3aoxA-3fmeA: 21.0	3aoxA-3fmeA: 26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CS9_A_NILA600_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 10	LEU A 59 VAL A 67 LYS A 82 VAL A 113 ILE A 127	STU A 1 (-3.8A) None STU A 1 ( 4.2A) None None	0.54A	3cs9A-3fmeA: 17.5	3cs9A-3fmeA: 27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CS9_B_NILB600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 9	LEU A 59 VAL A 67 LYS A 82 VAL A 113 ILE A 127 LEU A 186	STU A 1 (-3.8A) None STU A 1 ( 4.2A) None None STU A 1 (-4.4A)	0.66A	3cs9B-3fmeA: 18.2	3cs9B-3fmeA: 27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CS9_C_NILC600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 9	LEU A 59 VAL A 67 LYS A 82 VAL A 113 ILE A 127 MET A 132	STU A 1 (-3.8A) None STU A 1 ( 4.2A) None None None	0.74A	3cs9C-3fmeA: 17.8	3cs9C-3fmeA: 27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CS9_C_NILC600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 9	VAL A 67 LYS A 82 ILE A 127 MET A 132 VAL A 185	None STU A 1 ( 4.2A) None None None	1.39A	3cs9C-3fmeA: 17.8	3cs9C-3fmeA: 27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CS9_D_NILD600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LEU A 59 VAL A 67 LYS A 82 LEU A 186	STU A 1 (-3.8A) None STU A 1 ( 4.2A) STU A 1 (-4.4A)	0.63A	3cs9D-3fmeA: 17.8	3cs9D-3fmeA: 27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EYG_A_MI1A1_1 (TYROSINE-PROTEIN KINASE)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	9 / 12	LEU A 59 GLY A 60 GLY A 62 GLY A 65 VAL A 67 ALA A 80 MET A 129 SER A 135 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None None None STU A 1 (-3.4A) STU A 1 ( 3.8A) STU A 1 (-3.2A) STU A 1 (-4.4A)	0.62A	3eygA-3fmeA: 16.6	3eygA-3fmeA: 28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EYG_A_MI1A1_1 (TYROSINE-PROTEIN KINASE)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	10 / 12	LEU A 59 GLY A 60 GLY A 65 VAL A 67 ALA A 80 LYS A 82 MET A 129 SER A 135 ASN A 184 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None None STU A 1 (-3.4A) STU A 1 ( 4.2A) STU A 1 ( 3.8A) STU A 1 (-3.2A) STU A 1 ( 4.9A) STU A 1 (-4.4A)	0.69A	3eygA-3fmeA: 16.6	3eygA-3fmeA: 28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FUP_A_MI1A1_1 (TYROSINE-PROTEIN KINASE JAK2)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	9 / 12	LEU A 59 GLY A 60 GLY A 62 GLY A 65 VAL A 67 ALA A 80 MET A 129 SER A 135 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None None None STU A 1 (-3.4A) STU A 1 ( 3.8A) STU A 1 (-3.2A) STU A 1 (-4.4A)	0.70A	3fupA-3fmeA: 21.5	3fupA-3fmeA: 26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FUP_A_MI1A1_1 (TYROSINE-PROTEIN KINASE JAK2)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	9 / 12	LEU A 59 GLY A 60 GLY A 65 VAL A 67 ALA A 80 LYS A 82 MET A 129 SER A 135 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None None STU A 1 (-3.4A) STU A 1 ( 4.2A) STU A 1 ( 3.8A) STU A 1 (-3.2A) STU A 1 (-4.4A)	0.71A	3fupA-3fmeA: 21.5	3fupA-3fmeA: 26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FUP_B_MI1B1_1 (TYROSINE-PROTEIN KINASE JAK2)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	9 / 12	LEU A 59 GLY A 60 GLY A 62 VAL A 67 ALA A 80 LYS A 82 VAL A 113 MET A 129 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None None STU A 1 (-3.4A) STU A 1 ( 4.2A) None STU A 1 ( 3.8A) STU A 1 (-4.4A)	0.56A	3fupB-3fmeA: 21.5	3fupB-3fmeA: 26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IK3_A_0LIA1_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 7	LEU A 59 LYS A 82 ILE A 127 MET A 132	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None	0.53A	3ik3A-3fmeA: 17.2	3ik3A-3fmeA: 26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IK3_B_0LIB2_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 7	LEU A 59 LYS A 82 ILE A 127 MET A 132	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None	0.54A	3ik3B-3fmeA: 17.3	3ik3B-3fmeA: 26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K5V_A_STIA2_2 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LEU A 59 LYS A 82 ILE A 127 MET A 132	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None	0.55A	3k5vA-3fmeA: 21.3	3k5vA-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K5V_A_STIA2_2 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LEU A 59 LYS A 82 VAL A 113 ILE A 127	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None	0.57A	3k5vA-3fmeA: 21.3	3k5vA-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K5V_B_STIB2_2 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 6	LEU A 59 LYS A 82 VAL A 113 ILE A 127 MET A 132	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None None	0.74A	3k5vB-3fmeA: 16.8	3k5vB-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LS4_H_TCIH220_1 (HEAVY CHAIN OF ANTIBODY FAB FRAGMENT)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 10	VAL A 324 VAL A 328 LEU A 332 GLY A 191 VAL A 193	None	1.00A	3ls4H-3fmeA: undetectable	3ls4H-3fmeA: 23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LXK_A_MI1A1125_1 (TYROSINE-PROTEIN KINASE JAK3)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	8 / 12	LEU A 59 GLY A 60 VAL A 67 ALA A 80 LYS A 82 VAL A 113 MET A 129 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None STU A 1 (-3.4A) STU A 1 ( 4.2A) None STU A 1 ( 3.8A) STU A 1 (-4.4A)	0.79A	3lxkA-3fmeA: 21.5	3lxkA-3fmeA: 24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LXN_A_MI1A1_1 (NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	7 / 12	LEU A 59 GLY A 60 GLY A 62 VAL A 67 ALA A 80 SER A 135 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None None STU A 1 (-3.4A) STU A 1 (-3.2A) STU A 1 (-4.4A)	0.48A	3lxnA-3fmeA: 21.8	3lxnA-3fmeA: 27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LXN_A_MI1A1_1 (NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	7 / 12	LEU A 59 GLY A 60 VAL A 67 ALA A 80 LYS A 82 SER A 135 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None STU A 1 (-3.4A) STU A 1 ( 4.2A) STU A 1 (-3.2A) STU A 1 (-4.4A)	0.50A	3lxnA-3fmeA: 21.8	3lxnA-3fmeA: 27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MS9_A_STIA1_2 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LYS A 82 VAL A 113 ILE A 127 MET A 132	STU A 1 ( 4.2A) None None None	0.62A	3ms9A-3fmeA: 17.6	3ms9A-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MS9_B_STIB1_2 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 7	LYS A 82 VAL A 113 ILE A 127 MET A 132	STU A 1 ( 4.2A) None None None	0.64A	3ms9B-3fmeA: 17.7	3ms9B-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MSS_A_STIA1_2 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LYS A 82 VAL A 113 ILE A 127 MET A 132	STU A 1 ( 4.2A) None None None	0.61A	3mssA-3fmeA: 17.8	3mssA-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MSS_B_STIB1_2 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 7	LYS A 82 VAL A 113 ILE A 127 MET A 132	STU A 1 ( 4.2A) None None None	0.63A	3mssB-3fmeA: 17.7	3mssB-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MSS_C_STIC1_2 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	LYS A 82 VAL A 113 ILE A 127 MET A 132	STU A 1 ( 4.2A) None None None	0.65A	3mssC-3fmeA: 17.7	3mssC-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MSS_D_STID1_2 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 6	VAL A 67 LYS A 82 VAL A 113 ILE A 127 MET A 132	None STU A 1 ( 4.2A) None None None	0.65A	3mssD-3fmeA: 17.9	3mssD-3fmeA: 26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXZ_A_0LIA1_2 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 9	LEU A 59 LYS A 82 ILE A 127 MET A 132 LEU A 186	STU A 1 (-3.8A) STU A 1 ( 4.2A) None None STU A 1 (-4.4A)	0.50A	3oxzA-3fmeA: 17.3	3oxzA-3fmeA: 27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UG2_A_IREA1_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	7 / 12	LEU A 59 VAL A 67 ALA A 80 LYS A 82 LEU A 131 MET A 132 LEU A 186	STU A 1 (-3.8A) None STU A 1 (-3.4A) STU A 1 ( 4.2A) STU A 1 (-4.6A) None STU A 1 (-4.4A)	0.69A	3ug2A-3fmeA: 15.7	3ug2A-3fmeA: 28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UG2_A_IREA1_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	7 / 12	LEU A 59 VAL A 67 ALA A 80 LYS A 82 MET A 132 ASP A 137 LEU A 186	STU A 1 (-3.8A) None STU A 1 (-3.4A) STU A 1 ( 4.2A) None STU A 1 (-3.5A) STU A 1 (-4.4A)	0.91A	3ug2A-3fmeA: 15.7	3ug2A-3fmeA: 28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ANS_A_VGHA9000_1 (ALK TYROSINE KINASE RECEPTOR)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 9	LEU A 59 VAL A 67 ALA A 80 MET A 129 MET A 132 LEU A 186	STU A 1 (-3.8A) None STU A 1 (-3.4A) STU A 1 ( 3.8A) None STU A 1 (-4.4A)	0.57A	4ansA-3fmeA: 21.1	4ansA-3fmeA: 27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CKI_A_ADNA2022_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 11	LEU A 59 GLY A 60 VAL A 67 ALA A 80 SER A 135 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None STU A 1 (-3.4A) STU A 1 (-3.2A) STU A 1 (-4.4A)	0.55A	4ckiA-3fmeA: 17.8	4ckiA-3fmeA: 25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_I_ACTI507_0 (RNA POLYMERASE 3D-POL)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	3 / 3	LYS A 181 PRO A 182 SER A 183	None None STU A 1 (-4.2A)	0.43A	4k50I-3fmeA: undetectable	4k50I-3fmeA: 20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L9I_A_8PRA601_1 (RHODOPSIN KINASE)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 7	ALA A 80 MET A 129 MET A 132 LEU A 186	STU A 1 (-3.4A) STU A 1 ( 3.8A) None STU A 1 (-4.4A)	0.65A	4l9iA-3fmeA: 8.6	4l9iA-3fmeA: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L9I_A_8PRA601_1 (RHODOPSIN KINASE)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 7	VAL A 67 ALA A 80 MET A 129 LEU A 186	None STU A 1 (-3.4A) STU A 1 ( 3.8A) STU A 1 (-4.4A)	0.63A	4l9iA-3fmeA: 8.6	4l9iA-3fmeA: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L9I_B_8PRB601_1 (RHODOPSIN KINASE)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 8	GLY A 62 ALA A 80 MET A 129 MET A 132 LEU A 186	None STU A 1 (-3.4A) STU A 1 ( 3.8A) None STU A 1 (-4.4A)	0.85A	4l9iB-3fmeA: 21.7	4l9iB-3fmeA: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L9I_B_8PRB601_1 (RHODOPSIN KINASE)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 8	GLY A 62 VAL A 67 ALA A 80 LYS A 82 MET A 129	None None STU A 1 (-3.4A) STU A 1 ( 4.2A) STU A 1 ( 3.8A)	0.42A	4l9iB-3fmeA: 21.7	4l9iB-3fmeA: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L9I_B_8PRB601_1 (RHODOPSIN KINASE)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 8	GLY A 62 VAL A 67 ALA A 80 MET A 129 LEU A 186	None None STU A 1 (-3.4A) STU A 1 ( 3.8A) STU A 1 (-4.4A)	0.67A	4l9iB-3fmeA: 21.7	4l9iB-3fmeA: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O0W_A_ADNA501_1 (AURORA KINASE A)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 6	LEU A 59 GLY A 60 VAL A 67 ALA A 80 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None STU A 1 (-3.4A) STU A 1 (-4.4A)	0.32A	4o0wA-3fmeA: 24.4	4o0wA-3fmeA: 27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OTI_A_MI1A1001_1 (SERINE/THREONINE-PRO TEIN KINASE N1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	9 / 12	LEU A 59 GLY A 60 GLY A 62 GLY A 65 VAL A 67 ALA A 80 LYS A 82 VAL A 113 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None None None STU A 1 (-3.4A) STU A 1 ( 4.2A) None STU A 1 (-4.4A)	0.58A	4otiA-3fmeA: 16.2	4otiA-3fmeA: 26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WBO_C_ANWC601_0 (RHODOPSIN KINASE)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 6	LEU A 59 ALA A 80 MET A 129 MET A 132 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.4A) STU A 1 ( 3.8A) None STU A 1 (-4.4A)	0.55A	4wboC-3fmeA: 21.6	4wboC-3fmeA: 22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XOY_A_DX4A401_0 (MITOGEN-ACTIVATED PROTEIN KINASE 1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	ALA A 80 LEU A 131 MET A 132 LEU A 186	STU A 1 (-3.4A) STU A 1 (-4.6A) None STU A 1 (-4.4A)	0.20A	4xoyA-3fmeA: 21.0	4xoyA-3fmeA: 26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP3_A_DX4A401_0 (MITOGEN-ACTIVATED PROTEIN KINASE 1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 6	ALA A 80 LEU A 131 MET A 132 LEU A 186	STU A 1 (-3.4A) STU A 1 (-4.6A) None STU A 1 (-4.4A)	0.30A	4xp3A-3fmeA: 21.0	4xp3A-3fmeA: 26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H2U_B_1N1B501_1 (PROTEIN-TYROSINE KINASE 6)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 12	LEU A 59 VAL A 67 ALA A 80 ILE A 127 LEU A 131 LEU A 186	STU A 1 (-3.8A) None STU A 1 (-3.4A) None STU A 1 (-4.6A) STU A 1 (-4.4A)	0.75A	5h2uB-3fmeA: 16.8	5h2uB-3fmeA: 26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H2U_D_1N1D504_1 (PROTEIN-TYROSINE KINASE 6)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 12	LEU A 59 VAL A 67 ALA A 80 ILE A 127 LEU A 131 LEU A 186	STU A 1 (-3.8A) None STU A 1 (-3.4A) None STU A 1 (-4.6A) STU A 1 (-4.4A)	0.64A	5h2uD-3fmeA: 16.7	5h2uD-3fmeA: 26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 12	VAL A 67 ALA A 80 LYS A 82 ILE A 127 ASP A 137 CYH A 196	None STU A 1 (-3.4A) STU A 1 ( 4.2A) None STU A 1 (-3.5A) STU A 1 ( 3.7A)	0.84A	5hesB-3fmeA: 17.9	5hesB-3fmeA: 26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LVN_A_ADNA402_1 (3-PHOSPHOINOSITIDE-D EPENDENT PROTEIN KINASE 1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 11	LEU A 59 GLY A 60 VAL A 67 ALA A 80 VAL A 113 LEU A 186	STU A 1 (-3.8A) STU A 1 (-3.5A) None STU A 1 (-3.4A) None STU A 1 (-4.4A)	0.37A	5lvnA-3fmeA: 22.9	5lvnA-3fmeA: 25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LW1_B_ADNB401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 9	GLY A 60 VAL A 67 ALA A 80 MET A 129 MET A 132	STU A 1 (-3.5A) None STU A 1 (-3.4A) STU A 1 ( 3.8A) None	0.48A	5lw1B-3fmeA: 20.8	5lw1B-3fmeA: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LW1_E_ADNE401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 10	GLY A 60 VAL A 67 ALA A 80 MET A 129 LEU A 131 MET A 132	STU A 1 (-3.5A) None STU A 1 (-3.4A) STU A 1 ( 3.8A) STU A 1 (-4.6A) None	0.49A	5lw1E-3fmeA: 20.5	5lw1E-3fmeA: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LW1_H_ADNH401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 9	GLY A 60 VAL A 67 ALA A 80 MET A 129 LEU A 131 MET A 132	STU A 1 (-3.5A) None STU A 1 (-3.4A) STU A 1 ( 3.8A) STU A 1 (-4.6A) None	0.52A	5lw1H-3fmeA: 20.8	5lw1H-3fmeA: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MO4_A_NILA601_1 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	5 / 10	LEU A 59 VAL A 67 LYS A 82 ILE A 127 MET A 132	STU A 1 (-3.8A) None STU A 1 ( 4.2A) None None	0.40A	5mo4A-3fmeA: 16.9	5mo4A-3fmeA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NKN_A_LOCA201_2 (NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	3 / 3	VAL A 324 LYS A 194 MET A 195	None	1.08A	5nknA-3fmeA: undetectable	5nknA-3fmeA: 15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TE0_A_XINA401_2 (AP2-ASSOCIATED PROTEIN KINASE 1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 5	LEU A 59 VAL A 67 MET A 129 CYH A 196	STU A 1 (-3.8A) None STU A 1 ( 3.8A) STU A 1 ( 3.7A)	0.62A	5te0A-3fmeA: 21.4	5te0A-3fmeA: 24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VC3_A_DB8A601_2 (WEE1-LIKE PROTEIN KINASE)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	4 / 4	VAL A 67 LYS A 82 VAL A 113 ASN A 184	None STU A 1 ( 4.2A) None STU A 1 ( 4.9A)	1.01A	5vc3A-3fmeA: 22.5	5vc3A-3fmeA: 23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HD4_A_STIA604_0 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 12	VAL A 67 ALA A 80 LYS A 82 VAL A 113 ILE A 127 LEU A 186	None STU A 1 (-3.4A) STU A 1 ( 4.2A) None None STU A 1 (-4.4A)	0.60A	6hd4A-3fmeA: 16.9	6hd4A-3fmeA: 16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HD4_B_STIB602_0 (TYROSINE-PROTEIN KINASE ABL1)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 12	VAL A 67 ALA A 80 LYS A 82 VAL A 113 ILE A 127 LEU A 186	None STU A 1 (-3.4A) STU A 1 ( 4.2A) None None STU A 1 (-4.4A)	0.58A	6hd4B-3fmeA: 16.7	6hd4B-3fmeA: 16.91

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FMO_E_ADNE351_1","CAMP-DEPENDENT PROTEIN KINASE","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",7,"LEU A  59;GLY A  60;VAL A  67;ALA A  80;VAL A 113;ASN A 184;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;STU A   1 (-3.4A);None;STU A   1 ( 4.9A);STU A   1 (-4.4A)","0.56A","1fmoE-3fmeA:22.4","1fmoE-3fmeA:26.87"],["1HK2_A_T44A3004_1","SERUM ALBUMIN","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"PHE A 313;ALA A 159;LEU A 155;MET A 247","None","0.95A","1hk2A-3fmeA:undetectable","1hk2A-3fmeA:19.52"],["1IEP_A_STIA201_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LYS A  82;VAL A 113;ILE A 127;MET A 132","STU A   1 ( 4.2A);None;None;None","0.67A","1iepA-3fmeA:17.7","1iepA-3fmeA:26.06"],["1IEP_B_STIB202_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LYS A  82;ILE A 127;MET A 132;LEU A 186","STU A   1 ( 4.2A);None;None;STU A   1 (-4.4A)","0.73A","1iepB-3fmeA:17.6","1iepB-3fmeA:26.06"],["1IEP_B_STIB202_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LYS A  82;VAL A 113;ILE A 127;LEU A 186","STU A   1 ( 4.2A);None;None;STU A   1 (-4.4A)","0.76A","1iepB-3fmeA:17.6","1iepB-3fmeA:26.06"],["1OPJ_B_STIB4_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;LYS A  82;ILE A 127;MET A 132","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None","0.52A","1opjB-3fmeA:17.0","1opjB-3fmeA:26.06"],["1SV9_A_DIFA701_1","PHOSPHOLIPASE A2","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"LEU A 308;ALA A 159;ILE A 162;GLY A 244;PHE A 287","None","1.12A","1sv9A-3fmeA:undetectable","1sv9A-3fmeA:18.56"],["2B17_A_DIFA701_1","PHOSPHOLIPASE A2 VRV-PL-VIIIA","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"LEU A 308;ALA A 159;ILE A 162;GLY A 244;PHE A 287","None","1.14A","2b17A-3fmeA:undetectable","2b17A-3fmeA:18.56"],["2EVA_A_ADNA498_1","TAK1 KINASE - TAB1 CHIMERA FUSION PROTEIN","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"GLY A  60;VAL A  67;ALA A  80;MET A 129;SER A 135;LEU A 186","STU A   1 (-3.5A);None;STU A   1 (-3.4A);STU A   1 ( 3.8A);STU A   1 (-3.2A);STU A   1 (-4.4A)","0.61A","2evaA-3fmeA:18.8","2evaA-3fmeA:28.53"],["2FUM_A_MIXA539_1","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",7,"LEU A  59;GLY A  60;VAL A  67;ALA A  80;ASP A 179;LYS A 181;ASN A 184","STU A   1 (-3.8A);STU A   1 (-3.5A);None;STU A   1 (-3.4A);None;None;STU A   1 ( 4.9A)","0.58A","2fumA-3fmeA:20.0","2fumA-3fmeA:28.39"],["2FUM_B_MIXB1539_1","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",7,"LEU A  59;GLY A  60;VAL A  67;ALA A  80;MET A 129;LYS A 181;ASN A 184","STU A   1 (-3.8A);STU A   1 (-3.5A);None;STU A   1 (-3.4A);STU A   1 ( 3.8A);None;STU A   1 ( 4.9A)","0.63A","2fumB-3fmeA:23.5","2fumB-3fmeA:28.39"],["2FUM_C_MIXC2539_1","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"LEU A  59;GLY A  60;VAL A  67;ALA A  80;MET A 129;ASN A 184","STU A   1 (-3.8A);STU A   1 (-3.5A);None;STU A   1 (-3.4A);STU A   1 ( 3.8A);STU A   1 ( 4.9A)","0.59A","2fumC-3fmeA:23.8","2fumC-3fmeA:28.39"],["2FUM_D_MIXD3539_1","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",7,"LEU A  59;GLY A  60;GLY A  62;VAL A  67;ALA A  80;MET A 129;ASN A 184","STU A   1 (-3.8A);STU A   1 (-3.5A);None;None;STU A   1 (-3.4A);STU A   1 ( 3.8A);STU A   1 ( 4.9A)","0.53A","2fumD-3fmeA:20.8","2fumD-3fmeA:28.39"],["2HYY_A_STIA600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;LYS A  82;VAL A 113;ILE A 127","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None","0.46A","2hyyA-3fmeA:17.7","2hyyA-3fmeA:27.27"],["2HYY_B_STIB600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;LYS A  82;ILE A 127;MET A 132","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None","0.52A","2hyyB-3fmeA:17.6","2hyyB-3fmeA:27.27"],["2HYY_B_STIB600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;LYS A  82;VAL A 113;ILE A 127","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None","0.52A","2hyyB-3fmeA:17.6","2hyyB-3fmeA:27.27"],["2HYY_C_STIC600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;LYS A  82;ILE A 127;MET A 132","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None","0.50A","2hyyC-3fmeA:17.3","2hyyC-3fmeA:27.27"],["2HYY_D_STID600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;LYS A  82;VAL A 113;MET A 132","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None","0.61A","2hyyD-3fmeA:17.5","2hyyD-3fmeA:27.27"],["2PRG_A_BRLA1_2","PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",3,"ILE A 154;ILE A 187;LEU A 278","None","0.53A","2prgA-3fmeA:undetectable","2prgA-3fmeA:22.81"],["3AOX_A_EMHA901_1","ALK TYROSINE KINASE RECEPTOR","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"LEU A  59;ALA A  80;VAL A 113;LEU A 131;MET A 132;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.4A);None;STU A   1 (-4.6A);None;STU A   1 (-4.4A)","0.72A","3aoxA-3fmeA:21.0","3aoxA-3fmeA:26.37"],["3CS9_A_NILA600_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"LEU A  59;VAL A  67;LYS A  82;VAL A 113;ILE A 127","STU A   1 (-3.8A);None;STU A   1 ( 4.2A);None;None","0.54A","3cs9A-3fmeA:17.5","3cs9A-3fmeA:27.12"],["3CS9_B_NILB600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"LEU A  59;VAL A  67;LYS A  82;VAL A 113;ILE A 127;LEU A 186","STU A   1 (-3.8A);None;STU A   1 ( 4.2A);None;None;STU A   1 (-4.4A)","0.66A","3cs9B-3fmeA:18.2","3cs9B-3fmeA:27.12"],["3CS9_C_NILC600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"LEU A  59;VAL A  67;LYS A  82;VAL A 113;ILE A 127;MET A 132","STU A   1 (-3.8A);None;STU A   1 ( 4.2A);None;None;None","0.74A","3cs9C-3fmeA:17.8","3cs9C-3fmeA:27.12"],["3CS9_C_NILC600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"VAL A  67;LYS A  82;ILE A 127;MET A 132;VAL A 185","None;STU A   1 ( 4.2A);None;None;None","1.39A","3cs9C-3fmeA:17.8","3cs9C-3fmeA:27.12"],["3CS9_D_NILD600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;VAL A  67;LYS A  82;LEU A 186","STU A   1 (-3.8A);None;STU A   1 ( 4.2A);STU A   1 (-4.4A)","0.63A","3cs9D-3fmeA:17.8","3cs9D-3fmeA:27.12"],["3EYG_A_MI1A1_1","TYROSINE-PROTEIN KINASE","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",9,"LEU A  59;GLY A  60;GLY A  62;GLY A  65;VAL A  67;ALA A  80;MET A 129;SER A 135;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;None;None;STU A   1 (-3.4A);STU A   1 ( 3.8A);STU A   1 (-3.2A);STU A   1 (-4.4A)","0.62A","3eygA-3fmeA:16.6","3eygA-3fmeA:28.39"],["3EYG_A_MI1A1_1","TYROSINE-PROTEIN KINASE","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",10,"LEU A  59;GLY A  60;GLY A  65;VAL A  67;ALA A  80;LYS A  82;MET A 129;SER A 135;ASN A 184;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;None;STU A   1 (-3.4A);STU A   1 ( 4.2A);STU A   1 ( 3.8A);STU A   1 (-3.2A);STU A   1 ( 4.9A);STU A   1 (-4.4A)","0.69A","3eygA-3fmeA:16.6","3eygA-3fmeA:28.39"],["3FUP_A_MI1A1_1","TYROSINE-PROTEIN KINASE JAK2","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",9,"LEU A  59;GLY A  60;GLY A  62;GLY A  65;VAL A  67;ALA A  80;MET A 129;SER A 135;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;None;None;STU A   1 (-3.4A);STU A   1 ( 3.8A);STU A   1 (-3.2A);STU A   1 (-4.4A)","0.70A","3fupA-3fmeA:21.5","3fupA-3fmeA:26.35"],["3FUP_A_MI1A1_1","TYROSINE-PROTEIN KINASE JAK2","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",9,"LEU A  59;GLY A  60;GLY A  65;VAL A  67;ALA A  80;LYS A  82;MET A 129;SER A 135;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;None;STU A   1 (-3.4A);STU A   1 ( 4.2A);STU A   1 ( 3.8A);STU A   1 (-3.2A);STU A   1 (-4.4A)","0.71A","3fupA-3fmeA:21.5","3fupA-3fmeA:26.35"],["3FUP_B_MI1B1_1","TYROSINE-PROTEIN KINASE JAK2","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",9,"LEU A  59;GLY A  60;GLY A  62;VAL A  67;ALA A  80;LYS A  82;VAL A 113;MET A 129;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;None;STU A   1 (-3.4A);STU A   1 ( 4.2A);None;STU A   1 ( 3.8A);STU A   1 (-4.4A)","0.56A","3fupB-3fmeA:21.5","3fupB-3fmeA:26.35"],["3IK3_A_0LIA1_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;LYS A  82;ILE A 127;MET A 132","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None","0.53A","3ik3A-3fmeA:17.2","3ik3A-3fmeA:26.58"],["3IK3_B_0LIB2_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;LYS A  82;ILE A 127;MET A 132","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None","0.54A","3ik3B-3fmeA:17.3","3ik3B-3fmeA:26.58"],["3K5V_A_STIA2_2","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;LYS A  82;ILE A 127;MET A 132","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None","0.55A","3k5vA-3fmeA:21.3","3k5vA-3fmeA:26.06"],["3K5V_A_STIA2_2","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;LYS A  82;VAL A 113;ILE A 127","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None","0.57A","3k5vA-3fmeA:21.3","3k5vA-3fmeA:26.06"],["3K5V_B_STIB2_2","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"LEU A  59;LYS A  82;VAL A 113;ILE A 127;MET A 132","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None;None","0.74A","3k5vB-3fmeA:16.8","3k5vB-3fmeA:26.06"],["3LS4_H_TCIH220_1","HEAVY CHAIN OF ANTIBODY FAB FRAGMENT","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"VAL A 324;VAL A 328;LEU A 332;GLY A 191;VAL A 193","None","1.00A","3ls4H-3fmeA:undetectable","3ls4H-3fmeA:23.99"],["3LXK_A_MI1A1125_1","TYROSINE-PROTEIN KINASE JAK3","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",8,"LEU A  59;GLY A  60;VAL A  67;ALA A  80;LYS A  82;VAL A 113;MET A 129;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;STU A   1 (-3.4A);STU A   1 ( 4.2A);None;STU A   1 ( 3.8A);STU A   1 (-4.4A)","0.79A","3lxkA-3fmeA:21.5","3lxkA-3fmeA:24.85"],["3LXN_A_MI1A1_1","NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",7,"LEU A  59;GLY A  60;GLY A  62;VAL A  67;ALA A  80;SER A 135;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;None;STU A   1 (-3.4A);STU A   1 (-3.2A);STU A   1 (-4.4A)","0.48A","3lxnA-3fmeA:21.8","3lxnA-3fmeA:27.81"],["3LXN_A_MI1A1_1","NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",7,"LEU A  59;GLY A  60;VAL A  67;ALA A  80;LYS A  82;SER A 135;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;STU A   1 (-3.4A);STU A   1 ( 4.2A);STU A   1 (-3.2A);STU A   1 (-4.4A)","0.50A","3lxnA-3fmeA:21.8","3lxnA-3fmeA:27.81"],["3MS9_A_STIA1_2","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LYS A  82;VAL A 113;ILE A 127;MET A 132","STU A   1 ( 4.2A);None;None;None","0.62A","3ms9A-3fmeA:17.6","3ms9A-3fmeA:26.06"],["3MS9_B_STIB1_2","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LYS A  82;VAL A 113;ILE A 127;MET A 132","STU A   1 ( 4.2A);None;None;None","0.64A","3ms9B-3fmeA:17.7","3ms9B-3fmeA:26.06"],["3MSS_A_STIA1_2","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LYS A  82;VAL A 113;ILE A 127;MET A 132","STU A   1 ( 4.2A);None;None;None","0.61A","3mssA-3fmeA:17.8","3mssA-3fmeA:26.06"],["3MSS_B_STIB1_2","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LYS A  82;VAL A 113;ILE A 127;MET A 132","STU A   1 ( 4.2A);None;None;None","0.63A","3mssB-3fmeA:17.7","3mssB-3fmeA:26.06"],["3MSS_C_STIC1_2","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LYS A  82;VAL A 113;ILE A 127;MET A 132","STU A   1 ( 4.2A);None;None;None","0.65A","3mssC-3fmeA:17.7","3mssC-3fmeA:26.06"],["3MSS_D_STID1_2","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"VAL A  67;LYS A  82;VAL A 113;ILE A 127;MET A 132","None;STU A   1 ( 4.2A);None;None;None","0.65A","3mssD-3fmeA:17.9","3mssD-3fmeA:26.06"],["3OXZ_A_0LIA1_2","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"LEU A  59;LYS A  82;ILE A 127;MET A 132;LEU A 186","STU A   1 (-3.8A);STU A   1 ( 4.2A);None;None;STU A   1 (-4.4A)","0.50A","3oxzA-3fmeA:17.3","3oxzA-3fmeA:27.33"],["3UG2_A_IREA1_1","EPIDERMAL GROWTH FACTOR RECEPTOR","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",7,"LEU A  59;VAL A  67;ALA A  80;LYS A  82;LEU A 131;MET A 132;LEU A 186","STU A   1 (-3.8A);None;STU A   1 (-3.4A);STU A   1 ( 4.2A);STU A   1 (-4.6A);None;STU A   1 (-4.4A)","0.69A","3ug2A-3fmeA:15.7","3ug2A-3fmeA:28.11"],["3UG2_A_IREA1_1","EPIDERMAL GROWTH FACTOR RECEPTOR","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",7,"LEU A  59;VAL A  67;ALA A  80;LYS A  82;MET A 132;ASP A 137;LEU A 186","STU A   1 (-3.8A);None;STU A   1 (-3.4A);STU A   1 ( 4.2A);None;STU A   1 (-3.5A);STU A   1 (-4.4A)","0.91A","3ug2A-3fmeA:15.7","3ug2A-3fmeA:28.11"],["4ANS_A_VGHA9000_1","ALK TYROSINE KINASE RECEPTOR","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"LEU A  59;VAL A  67;ALA A  80;MET A 129;MET A 132;LEU A 186","STU A   1 (-3.8A);None;STU A   1 (-3.4A);STU A   1 ( 3.8A);None;STU A   1 (-4.4A)","0.57A","4ansA-3fmeA:21.1","4ansA-3fmeA:27.06"],["4CKI_A_ADNA2022_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"LEU A  59;GLY A  60;VAL A  67;ALA A  80;SER A 135;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;STU A   1 (-3.4A);STU A   1 (-3.2A);STU A   1 (-4.4A)","0.55A","4ckiA-3fmeA:17.8","4ckiA-3fmeA:25.74"],["4K50_I_ACTI507_0","RNA POLYMERASE 3D-POL","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",3,"LYS A 181;PRO A 182;SER A 183","None;None;STU A   1 (-4.2A)","0.43A","4k50I-3fmeA:undetectable","4k50I-3fmeA:20.66"],["4L9I_A_8PRA601_1","RHODOPSIN KINASE","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"ALA A  80;MET A 129;MET A 132;LEU A 186","STU A   1 (-3.4A);STU A   1 ( 3.8A);None;STU A   1 (-4.4A)","0.65A","4l9iA-3fmeA:8.6","4l9iA-3fmeA:21.98"],["4L9I_A_8PRA601_1","RHODOPSIN KINASE","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"VAL A  67;ALA A  80;MET A 129;LEU A 186","None;STU A   1 (-3.4A);STU A   1 ( 3.8A);STU A   1 (-4.4A)","0.63A","4l9iA-3fmeA:8.6","4l9iA-3fmeA:21.98"],["4L9I_B_8PRB601_1","RHODOPSIN KINASE","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"GLY A  62;ALA A  80;MET A 129;MET A 132;LEU A 186","None;STU A   1 (-3.4A);STU A   1 ( 3.8A);None;STU A   1 (-4.4A)","0.85A","4l9iB-3fmeA:21.7","4l9iB-3fmeA:21.98"],["4L9I_B_8PRB601_1","RHODOPSIN KINASE","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"GLY A  62;VAL A  67;ALA A  80;LYS A  82;MET A 129","None;None;STU A   1 (-3.4A);STU A   1 ( 4.2A);STU A   1 ( 3.8A)","0.42A","4l9iB-3fmeA:21.7","4l9iB-3fmeA:21.98"],["4L9I_B_8PRB601_1","RHODOPSIN KINASE","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"GLY A  62;VAL A  67;ALA A  80;MET A 129;LEU A 186","None;None;STU A   1 (-3.4A);STU A   1 ( 3.8A);STU A   1 (-4.4A)","0.67A","4l9iB-3fmeA:21.7","4l9iB-3fmeA:21.98"],["4O0W_A_ADNA501_1","AURORA KINASE A","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"LEU A  59;GLY A  60;VAL A  67;ALA A  80;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;STU A   1 (-3.4A);STU A   1 (-4.4A)","0.32A","4o0wA-3fmeA:24.4","4o0wA-3fmeA:27.78"],["4OTI_A_MI1A1001_1","SERINE\/THREONINE-PROTEIN KINASE N1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",9,"LEU A  59;GLY A  60;GLY A  62;GLY A  65;VAL A  67;ALA A  80;LYS A  82;VAL A 113;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;None;None;STU A   1 (-3.4A);STU A   1 ( 4.2A);None;STU A   1 (-4.4A)","0.58A","4otiA-3fmeA:16.2","4otiA-3fmeA:26.45"],["4WBO_C_ANWC601_0","RHODOPSIN KINASE","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"LEU A  59;ALA A  80;MET A 129;MET A 132;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.4A);STU A   1 ( 3.8A);None;STU A   1 (-4.4A)","0.55A","4wboC-3fmeA:21.6","4wboC-3fmeA:22.83"],["4XOY_A_DX4A401_0","MITOGEN-ACTIVATED PROTEIN KINASE 1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"ALA A  80;LEU A 131;MET A 132;LEU A 186","STU A   1 (-3.4A);STU A   1 (-4.6A);None;STU A   1 (-4.4A)","0.20A","4xoyA-3fmeA:21.0","4xoyA-3fmeA:26.87"],["4XP3_A_DX4A401_0","MITOGEN-ACTIVATED PROTEIN KINASE 1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"ALA A  80;LEU A 131;MET A 132;LEU A 186","STU A   1 (-3.4A);STU A   1 (-4.6A);None;STU A   1 (-4.4A)","0.30A","4xp3A-3fmeA:21.0","4xp3A-3fmeA:26.87"],["5H2U_B_1N1B501_1","PROTEIN-TYROSINE KINASE 6","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"LEU A  59;VAL A  67;ALA A  80;ILE A 127;LEU A 131;LEU A 186","STU A   1 (-3.8A);None;STU A   1 (-3.4A);None;STU A   1 (-4.6A);STU A   1 (-4.4A)","0.75A","5h2uB-3fmeA:16.8","5h2uB-3fmeA:26.28"],["5H2U_D_1N1D504_1","PROTEIN-TYROSINE KINASE 6","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"LEU A  59;VAL A  67;ALA A  80;ILE A 127;LEU A 131;LEU A 186","STU A   1 (-3.8A);None;STU A   1 (-3.4A);None;STU A   1 (-4.6A);STU A   1 (-4.4A)","0.64A","5h2uD-3fmeA:16.7","5h2uD-3fmeA:26.28"],["5HES_B_032B401_1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"VAL A  67;ALA A  80;LYS A  82;ILE A 127;ASP A 137;CYH A 196","None;STU A   1 (-3.4A);STU A   1 ( 4.2A);None;STU A   1 (-3.5A);STU A   1 ( 3.7A)","0.84A","5hesB-3fmeA:17.9","5hesB-3fmeA:26.38"],["5LVN_A_ADNA402_1","3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"LEU A  59;GLY A  60;VAL A  67;ALA A  80;VAL A 113;LEU A 186","STU A   1 (-3.8A);STU A   1 (-3.5A);None;STU A   1 (-3.4A);None;STU A   1 (-4.4A)","0.37A","5lvnA-3fmeA:22.9","5lvnA-3fmeA:25.61"],["5LW1_B_ADNB401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"GLY A  60;VAL A  67;ALA A  80;MET A 129;MET A 132","STU A   1 (-3.5A);None;STU A   1 (-3.4A);STU A   1 ( 3.8A);None","0.48A","5lw1B-3fmeA:20.8","5lw1B-3fmeA:12.86"],["5LW1_E_ADNE401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"GLY A  60;VAL A  67;ALA A  80;MET A 129;LEU A 131;MET A 132","STU A   1 (-3.5A);None;STU A   1 (-3.4A);STU A   1 ( 3.8A);STU A   1 (-4.6A);None","0.49A","5lw1E-3fmeA:20.5","5lw1E-3fmeA:12.86"],["5LW1_H_ADNH401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"GLY A  60;VAL A  67;ALA A  80;MET A 129;LEU A 131;MET A 132","STU A   1 (-3.5A);None;STU A   1 (-3.4A);STU A   1 ( 3.8A);STU A   1 (-4.6A);None","0.52A","5lw1H-3fmeA:20.8","5lw1H-3fmeA:12.86"],["5MO4_A_NILA601_1","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",5,"LEU A  59;VAL A  67;LYS A  82;ILE A 127;MET A 132","STU A   1 (-3.8A);None;STU A   1 ( 4.2A);None;None","0.40A","5mo4A-3fmeA:16.9","5mo4A-3fmeA:21.34"],["5NKN_A_LOCA201_2","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",3,"VAL A 324;LYS A 194;MET A 195","None","1.08A","5nknA-3fmeA:undetectable","5nknA-3fmeA:15.71"],["5TE0_A_XINA401_2","AP2-ASSOCIATED PROTEIN KINASE 1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"LEU A  59;VAL A  67;MET A 129;CYH A 196","STU A   1 (-3.8A);None;STU A   1 ( 3.8A);STU A   1 ( 3.7A)","0.62A","5te0A-3fmeA:21.4","5te0A-3fmeA:24.29"],["5VC3_A_DB8A601_2","WEE1-LIKE PROTEIN KINASE","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",4,"VAL A  67;LYS A  82;VAL A 113;ASN A 184","None;STU A   1 ( 4.2A);None;STU A   1 ( 4.9A)","1.01A","5vc3A-3fmeA:22.5","5vc3A-3fmeA:23.49"],["6HD4_A_STIA604_0","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"VAL A  67;ALA A  80;LYS A  82;VAL A 113;ILE A 127;LEU A 186","None;STU A   1 (-3.4A);STU A   1 ( 4.2A);None;None;STU A   1 (-4.4A)","0.60A","6hd4A-3fmeA:16.9","6hd4A-3fmeA:16.91"],["6HD4_B_STIB602_0","TYROSINE-PROTEIN KINASE ABL1","3fme","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","Homo sapiens",6,"VAL A  67;ALA A  80;LYS A  82;VAL A 113;ILE A 127;LEU A 186","None;STU A   1 (-3.4A);STU A   1 ( 4.2A);None;None;STU A   1 (-4.4A)","0.58A","6hd4B-3fmeA:16.7","6hd4B-3fmeA:16.91"]]