SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fmo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DZY_A_9CRA463_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3fmo	ATP-DEPENDENT RNA HELICASE DDX19B (Homo sapiens)	5 / 12	ILE B 295 ALA B 122 GLN B 119 ASN B 73 ALA B 147	None None ADP B 301 (-3.2A) None None	1.12A	3dzyA-3fmoB: undetectable	3dzyA-3fmoB: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_B_CHDB102_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	3fmo	ATP-DEPENDENT RNA HELICASE DDX19B (Homo sapiens)	5 / 11	LEU B 97 LEU B 99 LEU B 127 ALA B 146 LEU B 150	None None None ADP B 301 (-3.5A) None	1.13A	4wg0B-3fmoB: undetectable 4wg0C-3fmoB: undetectable 4wg0D-3fmoB: undetectable	4wg0B-3fmoB: 3.67 4wg0C-3fmoB: 3.67 4wg0D-3fmoB: 3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_D_CHDD102_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	3fmo	ATP-DEPENDENT RNA HELICASE DDX19B (Homo sapiens)	5 / 11	LEU B 97 LEU B 99 LEU B 127 ALA B 146 LEU B 150	None None None ADP B 301 (-3.5A) None	1.13A	4wg0D-3fmoB: undetectable 4wg0E-3fmoB: undetectable 4wg0F-3fmoB: undetectable	4wg0D-3fmoB: 3.67 4wg0E-3fmoB: 3.67 4wg0F-3fmoB: 3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_P_CHDP307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3fmo	ATP-DEPENDENT RNA HELICASE DDX19B (Homo sapiens)	4 / 5	LEU B 103 GLN B 102 PHE B 188 PHE B 94	None	1.15A	6nmpP-3fmoB: undetectable 6nmpW-3fmoB: undetectable	6nmpP-3fmoB: 21.28 6nmpW-3fmoB: 13.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3DZY_A_9CRA463_1","RETINOIC ACID RECEPTOR RXR-ALPHA","3fmo","ATP-DEPENDENT RNA HELICASE DDX19B","Homo sapiens",5,"ILE B 295;ALA B 122;GLN B 119;ASN B  73;ALA B 147","None;None;ADP B 301 (-3.2A);None;None","1.12A","3dzyA-3fmoB:undetectable","3dzyA-3fmoB:20.22"],["4WG0_B_CHDB102_0","NUCLEAR RECEPTOR COACTIVATOR 2","3fmo","ATP-DEPENDENT RNA HELICASE DDX19B","Homo sapiens",5,"LEU B  97;LEU B  99;LEU B 127;ALA B 146;LEU B 150","None;None;None;ADP B 301 (-3.5A);None","1.13A","4wg0B-3fmoB:undetectable;4wg0C-3fmoB:undetectable;4wg0D-3fmoB:undetectable","4wg0B-3fmoB:3.67;4wg0C-3fmoB:3.67;4wg0D-3fmoB:3.67"],["4WG0_D_CHDD102_0","NUCLEAR RECEPTOR COACTIVATOR 2","3fmo","ATP-DEPENDENT RNA HELICASE DDX19B","Homo sapiens",5,"LEU B  97;LEU B  99;LEU B 127;ALA B 146;LEU B 150","None;None;None;ADP B 301 (-3.5A);None","1.13A","4wg0D-3fmoB:undetectable;4wg0E-3fmoB:undetectable;4wg0F-3fmoB:undetectable","4wg0D-3fmoB:3.67;4wg0E-3fmoB:3.67;4wg0F-3fmoB:3.67"],["6NMP_P_CHDP307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3fmo","ATP-DEPENDENT RNA HELICASE DDX19B","Homo sapiens",4,"LEU B 103;GLN B 102;PHE B 188;PHE B  94","None","1.15A","6nmpP-3fmoB:undetectable;6nmpW-3fmoB:undetectable","6nmpP-3fmoB:21.28;6nmpW-3fmoB:13.50"]]