SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 10 GLY A 112
ALA A 118
ILE A 114
SER A 120
ALA A 119
 None
 1.04A 1gtnU-3fmsA:
undetectable
1gtnV-3fmsA:
undetectable		 1gtnU-3fmsA:
17.11
1gtnV-3fmsA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.21A 1hrkB-3fmsA:
undetectable		 1hrkB-3fmsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		3 / 3 ASP A  73
LYS A  77
ARG A  80
 None
 1.06A 1ra8A-3fmsA:
undetectable		 1ra8A-3fmsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 THR A  72
GLU A  30
LEU A  32
LEU A  26
LEU A 159
 None
 1.08A 2jfaA-3fmsA:
undetectable		 2jfaA-3fmsA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.21A 2po7A-3fmsA:
undetectable		 2po7A-3fmsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.19A 2po7B-3fmsA:
undetectable		 2po7B-3fmsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 THR A  72
GLU A  30
LEU A  32
LEU A  26
LEU A 159
 None
 1.13A 2qxsB-3fmsA:
undetectable		 2qxsB-3fmsA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		4 / 6 LEU A  32
GLY A  68
LEU A  37
SER A  38
 None
ACT  A 303 ( 3.8A)
None
None
 0.66A 3aiaA-3fmsA:
undetectable		 3aiaA-3fmsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.24A 3aqiB-3fmsA:
undetectable		 3aqiB-3fmsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 9 LEU A  52
LEU A  17
GLU A  36
PHE A  69
GLU A  30
 None
None
None
ACT  A 303 ( 4.3A)
None
 1.29A 3tmzA-3fmsA:
1.2		 3tmzA-3fmsA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.21A 3w1wA-3fmsA:
undetectable		 3w1wA-3fmsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.21A 3w1wB-3fmsA:
undetectable		 3w1wB-3fmsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
GLU A  90
ARG A  86
ILE A 114
LEU A 107
 None
None
ACT  A 302 (-3.0A)
None
None
 1.17A 4j24B-3fmsA:
undetectable		 4j24B-3fmsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
GLU A  90
ARG A  86
ILE A 114
LEU A 107
 None
None
ACT  A 302 (-3.0A)
None
None
 1.17A 4j26B-3fmsA:
undetectable		 4j26B-3fmsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 133
ARG A 132
ALA A 118
ILE A 181
GLY A 103
 None
 1.21A 4l9qA-3fmsA:
3.2		 4l9qA-3fmsA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 11 LEU A  26
GLU A  19
LEU A  17
LEU A  37
LEU A  32
 None
 1.17A 4wg0G-3fmsA:
undetectable
4wg0H-3fmsA:
undetectable
4wg0I-3fmsA:
undetectable		 4wg0G-3fmsA:
9.52
4wg0H-3fmsA:
9.52
4wg0I-3fmsA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 11 LEU A  26
GLU A  19
LEU A  17
LEU A  37
LEU A  32
 None
 1.09A 4wg0K-3fmsA:
undetectable
4wg0L-3fmsA:
undetectable
4wg0M-3fmsA:
undetectable		 4wg0K-3fmsA:
9.52
4wg0L-3fmsA:
9.52
4wg0M-3fmsA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A  32
LEU A  55
LEU A  16
ASN A  15
ALA A  51
 None
 1.20A 4x1kA-3fmsA:
undetectable
4x1kB-3fmsA:
undetectable		 4x1kA-3fmsA:
21.45
4x1kB-3fmsA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		3 / 3 HIS A 174
HIS A 134
HIS A 196
 NI  A 301 (-3.3A)
NI  A 301 ( 3.3A)
NI  A 301 ( 3.3A)
 0.61A 5zrdA-3fmsA:
undetectable		 5zrdA-3fmsA:
17.91