SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fmx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		5 / 11 ILE X 263
ALA X 266
ARG X 111
VAL X 116
ALA X 119
 NAI  X 401 (-4.5A)
None
None
None
None
 1.13A 1n4hA-3fmxX:
undetectable		 1n4hA-3fmxX:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		3 / 3 ASP X  71
TYR X  70
GLU X  40
 None
 0.86A 1vm1A-3fmxX:
undetectable		 1vm1A-3fmxX:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 5 LEU X 172
GLY X 249
ALA X 175
ILE X 171
 None
 0.68A 2aohB-3fmxX:
undetectable		 2aohB-3fmxX:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 5 GLY X 346
PRO X 117
VAL X 116
ILE X 335
 None
 0.86A 2aoiA-3fmxX:
undetectable		 2aoiA-3fmxX:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 8 ASP X 250
LEU X  90
TYR X 141
LEU X 280
 NAI  X 401 ( 4.5A)
None
None
None
 1.00A 2bfpC-3fmxX:
2.7		 2bfpC-3fmxX:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 8 ASP X 250
LEU X  90
TYR X 141
LEU X 280
 NAI  X 401 ( 4.5A)
None
None
None
 0.97A 2bfpD-3fmxX:
undetectable		 2bfpD-3fmxX:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 7 GLN X 103
ILE X 107
SER X 279
TYR X 104
 None
 1.32A 2xz5D-3fmxX:
undetectable
2xz5E-3fmxX:
undetectable		 2xz5D-3fmxX:
18.75
2xz5E-3fmxX:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		5 / 11 ASP X 250
SER X 253
SER X 268
PHE X 281
GLU X 282
 NAI  X 401 ( 4.5A)
None
None
None
NAI  X 401 ( 3.2A)
 1.31A 3ko0A-3fmxX:
undetectable
3ko0B-3fmxX:
0.0
3ko0C-3fmxX:
undetectable
3ko0D-3fmxX:
undetectable		 3ko0A-3fmxX:
13.35
3ko0B-3fmxX:
13.35
3ko0C-3fmxX:
13.35
3ko0D-3fmxX:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG202_1
(PROTEIN S100-A4)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		5 / 10 ASP X 250
SER X 253
SER X 268
PHE X 281
GLU X 282
 NAI  X 401 ( 4.5A)
None
None
None
NAI  X 401 ( 3.2A)
 1.38A 3ko0E-3fmxX:
undetectable
3ko0F-3fmxX:
undetectable
3ko0G-3fmxX:
0.0
3ko0H-3fmxX:
undetectable		 3ko0E-3fmxX:
13.35
3ko0F-3fmxX:
13.35
3ko0G-3fmxX:
13.35
3ko0H-3fmxX:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		5 / 11 SER X 268
PHE X 281
GLU X 282
ASP X 250
SER X 253
 None
None
NAI  X 401 ( 3.2A)
NAI  X 401 ( 4.5A)
None
 1.36A 3ko0O-3fmxX:
undetectable
3ko0P-3fmxX:
undetectable
3ko0Q-3fmxX:
undetectable
3ko0R-3fmxX:
undetectable		 3ko0O-3fmxX:
13.35
3ko0P-3fmxX:
13.35
3ko0Q-3fmxX:
13.35
3ko0R-3fmxX:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_A_P77A203_1
(PROTEIN S100-A4)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		5 / 10 ASP X 250
SER X 253
GLU X 282
SER X 268
PHE X 281
 NAI  X 401 ( 4.5A)
None
NAI  X 401 ( 3.2A)
None
None
 1.29A 3m0wA-3fmxX:
0.6
3m0wB-3fmxX:
undetectable
3m0wI-3fmxX:
undetectable
3m0wJ-3fmxX:
undetectable		 3m0wA-3fmxX:
13.41
3m0wB-3fmxX:
13.41
3m0wI-3fmxX:
13.41
3m0wJ-3fmxX:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B203_1
(PROTEIN S100-A4)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		5 / 9 ASP X 250
SER X 253
SER X 268
PHE X 281
GLU X 282
 NAI  X 401 ( 4.5A)
None
None
None
NAI  X 401 ( 3.2A)
 1.32A 3m0wA-3fmxX:
0.6
3m0wB-3fmxX:
undetectable
3m0wC-3fmxX:
undetectable
3m0wD-3fmxX:
undetectable		 3m0wA-3fmxX:
13.41
3m0wB-3fmxX:
13.41
3m0wC-3fmxX:
13.41
3m0wD-3fmxX:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		5 / 10 ASP X 250
SER X 253
SER X 268
PHE X 281
GLU X 282
 NAI  X 401 ( 4.5A)
None
None
None
NAI  X 401 ( 3.2A)
 1.34A 3m0wC-3fmxX:
undetectable
3m0wD-3fmxX:
undetectable
3m0wE-3fmxX:
0.7
3m0wF-3fmxX:
0.7		 3m0wC-3fmxX:
13.41
3m0wD-3fmxX:
13.41
3m0wE-3fmxX:
13.41
3m0wF-3fmxX:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_D_P77D203_1
(PROTEIN S100-A4)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		5 / 10 SER X 268
PHE X 281
GLU X 282
ASP X 250
SER X 253
 None
None
NAI  X 401 ( 3.2A)
NAI  X 401 ( 4.5A)
None
 1.32A 3m0wA-3fmxX:
0.6
3m0wB-3fmxX:
undetectable
3m0wC-3fmxX:
undetectable
3m0wD-3fmxX:
undetectable		 3m0wA-3fmxX:
13.41
3m0wB-3fmxX:
13.41
3m0wC-3fmxX:
13.41
3m0wD-3fmxX:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		5 / 10 ASP X  86
TYR X 141
SER X  89
GLY X  92
ASP X 250
 NAI  X 401 (-2.7A)
None
None
None
NAI  X 401 ( 4.5A)
 1.44A 4mmcA-3fmxX:
undetectable		 4mmcA-3fmxX:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		5 / 10 ALA X 330
VAL X  27
ILE X 265
VAL X 353
ILE X 357
 None
 1.11A 4q1wB-3fmxX:
undetectable		 4q1wB-3fmxX:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		5 / 11 SER X 189
PHE X 176
ASP X 177
VAL X 240
ILE X 171
 None
 0.96A 4uuuB-3fmxX:
undetectable		 4uuuB-3fmxX:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		3 / 3 ASP X 317
ARG X 319
TYR X 320
 None
 0.91A 5a7mA-3fmxX:
2.4		 5a7mA-3fmxX:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		3 / 3 ASP X 317
ARG X 319
TYR X 320
 None
 0.89A 5a7mB-3fmxX:
2.1		 5a7mB-3fmxX:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 7 ARG X  99
SER X 142
ARG X 166
GLY X 167
 None
 0.94A 5btaA-3fmxX:
undetectable
5btaC-3fmxX:
undetectable
5btaD-3fmxX:
2.4		 5btaA-3fmxX:
22.91
5btaC-3fmxX:
22.91
5btaD-3fmxX:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 6 SER X 142
ARG X 166
GLY X 167
ARG X  99
 None
 0.88A 5btaA-3fmxX:
undetectable
5btaB-3fmxX:
undetectable
5btaC-3fmxX:
undetectable		 5btaA-3fmxX:
22.91
5btaB-3fmxX:
21.96
5btaC-3fmxX:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 6 ARG X  99
SER X 142
ARG X 166
GLY X 167
 None
 0.86A 5btcA-3fmxX:
undetectable
5btcC-3fmxX:
undetectable
5btcD-3fmxX:
2.2		 5btcA-3fmxX:
22.91
5btcC-3fmxX:
22.91
5btcD-3fmxX:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 6 SER X 142
ARG X 166
GLY X 167
ARG X  99
 None
 0.81A 5btcA-3fmxX:
undetectable
5btcB-3fmxX:
2.2
5btcC-3fmxX:
undetectable		 5btcA-3fmxX:
22.91
5btcB-3fmxX:
21.96
5btcC-3fmxX:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 7 SER X 142
ARG X 166
GLY X 167
ARG X  99
 None
 0.86A 5btfA-3fmxX:
undetectable
5btfB-3fmxX:
undetectable
5btfC-3fmxX:
undetectable		 5btfA-3fmxX:
22.91
5btfB-3fmxX:
21.96
5btfC-3fmxX:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 8 THR X 350
ILE X  16
PRO X 283
MET X 302
 None
None
NH4  X 402 (-3.5A)
None
 0.86A 5g48A-3fmxX:
undetectable		 5g48A-3fmxX:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE
(Pseudomonas
putida) 		4 / 6 ASP X 177
ILE X 171
ARG X 170
TYR X 104
 None
 1.23A 5igyA-3fmxX:
undetectable		 5igyA-3fmxX:
22.45