SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 11 LEU A 217
GLY A 195
THR A 252
VAL A 155
VAL A 158
 None
 1.26A 1akdA-3fn4A:
undetectable		 1akdA-3fn4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		3 / 3 ALA A 292
VAL A 294
TRP A 321
 None
 0.84A 1bdwA-3fn4A:
undetectable
1bdwB-3fn4A:
undetectable		 1bdwA-3fn4A:
3.01
1bdwB-3fn4A:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 12 THR A 252
GLY A 195
ALA A 199
GLY A 203
ALA A 198
 None
 0.85A 1bx4A-3fn4A:
4.7		 1bx4A-3fn4A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 12 GLY A 276
GLY A 300
VAL A 250
ASP A 249
ARG A 185
 None
 1.27A 1n2xA-3fn4A:
8.3		 1n2xA-3fn4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		6 / 11 LEU A 217
VAL A 194
GLY A 195
THR A 252
VAL A 155
VAL A 158
 None
 1.41A 1phgA-3fn4A:
undetectable		 1phgA-3fn4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		3 / 3 SER A 334
GLY A 335
ARG A 284
 GOL  A 402 (-3.4A)
GOL  A 402 (-3.5A)
GOL  A 402 (-2.5A)
 0.37A 1t9wA-3fn4A:
undetectable		 1t9wA-3fn4A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 12 THR A 119
GLY A 121
GLY A 335
ILE A  94
GLN A  96
 None
GOL  A 402 ( 4.0A)
GOL  A 402 (-3.5A)
None
None
 1.26A 2akeA-3fn4A:
undetectable		 2akeA-3fn4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 12 THR A 119
GLY A 121
GLY A 335
ILE A  94
GLN A  96
 None
GOL  A 402 ( 4.0A)
GOL  A 402 (-3.5A)
None
None
 1.27A 2azxA-3fn4A:
undetectable		 2azxA-3fn4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 12 THR A 119
GLY A 121
GLY A 335
ILE A  94
GLN A  96
 None
GOL  A 402 ( 4.0A)
GOL  A 402 (-3.5A)
None
None
 1.29A 2azxB-3fn4A:
undetectable		 2azxB-3fn4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 10 PHE A  98
GLY A 347
THR A 348
ALA A 345
ALA A 346
 GOL  A 402 ( 4.7A)
None
None
None
None
 0.86A 2ej3B-3fn4A:
undetectable		 2ej3B-3fn4A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		4 / 7 TYR A 344
CYH A 145
ILE A 122
SER A 337
 None
None
GOL  A 402 (-4.2A)
None
 1.28A 2xz5A-3fn4A:
undetectable
2xz5B-3fn4A:
undetectable		 2xz5A-3fn4A:
19.51
2xz5B-3fn4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		4 / 7 ILE A 122
SER A 337
TYR A 344
CYH A 145
 GOL  A 402 (-4.2A)
None
None
None
 1.23A 2xz5D-3fn4A:
undetectable
2xz5E-3fn4A:
undetectable		 2xz5D-3fn4A:
19.51
2xz5E-3fn4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 9 VAL A 309
GLY A 285
ILE A 293
TYR A 305
GLY A 307
 None
 1.37A 3csjB-3fn4A:
undetectable		 3csjB-3fn4A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		4 / 8 GLY A  51
GLN A 341
GLN A  96
THR A 336
 None
 0.91A 3rglA-3fn4A:
undetectable		 3rglA-3fn4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 12 ALA A 131
LEU A 103
THR A 119
ALA A 117
ILE A  93
 None
 1.15A 3ut5B-3fn4A:
undetectable		 3ut5B-3fn4A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 9 LEU A 217
GLY A 195
THR A 252
VAL A 155
VAL A 158
 None
 1.25A 4c9kB-3fn4A:
undetectable		 4c9kB-3fn4A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		4 / 6 ARG A 349
ILE A  94
VAL A   3
LEU A  70
 None
 0.89A 4em2A-3fn4A:
undetectable		 4em2A-3fn4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		3 / 3 PRO A 312
TYR A 102
GLY A 389
 None
 0.75A 4g2zA-3fn4A:
undetectable		 4g2zA-3fn4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 12 ALA A 120
LEU A  59
LEU A  57
LEU A  50
LEU A 118
 None
 1.23A 4zn7A-3fn4A:
undetectable		 4zn7A-3fn4A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 9 LEU A 217
VAL A 194
GLY A 195
THR A 252
VAL A 158
 None
 1.36A 5cp4A-3fn4A:
undetectable		 5cp4A-3fn4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 9 LEU A 217
VAL A 194
THR A 252
VAL A 155
VAL A 158
 None
 1.35A 5cp4A-3fn4A:
undetectable		 5cp4A-3fn4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		4 / 8 GLY A  47
GLN A 341
LEU A 338
THR A 342
 None
 0.97A 5sxqA-3fn4A:
undetectable		 5sxqA-3fn4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		4 / 8 GLY A  47
GLN A 341
LEU A 338
THR A 342
 None
 0.88A 5sxtA-3fn4A:
undetectable		 5sxtA-3fn4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		4 / 8 GLY A  47
GLN A 341
LEU A 338
THR A 342
 None
 0.91A 5sxtB-3fn4A:
undetectable		 5sxtB-3fn4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		4 / 8 GLY A  47
GLN A 341
LEU A 338
THR A 342
 None
 0.93A 5syjA-3fn4A:
undetectable		 5syjA-3fn4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		4 / 8 GLY A  47
GLN A 341
LEU A 338
THR A 342
 None
 0.83A 5syjB-3fn4A:
undetectable		 5syjB-3fn4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		3 / 3 GLU A 364
ARG A 362
TYR A 365
 None
 0.66A 5trqB-3fn4A:
undetectable		 5trqB-3fn4A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 9 SER A 339
PHE A  44
SER A  52
GLY A  55
THR A 348
 None
 1.42A 6awpA-3fn4A:
undetectable		 6awpA-3fn4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Moraxella
sp.) 		5 / 9 VAL A 194
HIS A 218
ALA A 151
VAL A 150
SER A 147
 None
None
None
GOL  A 402 (-4.8A)
SO4  A 403 ( 4.5A)
 1.45A 6c2mA-3fn4A:
undetectable		 6c2mA-3fn4A:
12.18