SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3fn5 SORTASE A
(Streptococcus
pyogenes) 		5 / 12 ILE A 144
GLN A 246
ILE A 105
ASN A 106
LEU A 107
 None
 1.17A 1dhfA-3fn5A:
undetectable		 1dhfA-3fn5A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3fn5 SORTASE A
(Streptococcus
pyogenes) 		4 / 5 TYR A 178
LYS A 220
VAL A 191
ILE A 218
 None
 1.34A 1opjA-3fn5A:
undetectable		 1opjA-3fn5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3fn5 SORTASE A
(Streptococcus
pyogenes) 		4 / 5 PHE A 145
ILE A 211
CYH A 208
HIS A 143
 None
 1.04A 3r0lD-3fn5A:
undetectable		 3r0lD-3fn5A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3fn5 SORTASE A
(Streptococcus
pyogenes) 		4 / 5 GLU A 202
SER A 138
GLN A 129
ASP A 192
 None
 1.45A 5fhrB-3fn5A:
undetectable		 5fhrB-3fn5A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 3fn5 SORTASE A
(Streptococcus
pyogenes) 		5 / 12 ASN A 241
PHE A 240
LEU A 237
ASP A 171
ILE A 109
 None
 1.34A 6dwnB-3fn5A:
undetectable		 6dwnB-3fn5A:
19.30