SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fnc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D4S_A_TIMA401_2 (BETA-2 ADRENERGIC RECEPTOR/T4-LYSOZYME CHIMERA)	3fnc	PUTATIVE ACETYLTRANSFERASE (Listeria innocua)	3 / 3	THR A 27 SER A 23 PHE A 40	None None MLI A 161 (-4.8A)	0.67A	3d4sA-3fncA: undetectable	3d4sA-3fncA: 16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_D_SAMD300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	3fnc	PUTATIVE ACETYLTRANSFERASE (Listeria innocua)	5 / 12	LEU A 89 TYR A 88 TYR A 45 ALA A 72 GLY A 70	EDO A 165 (-4.9A) EDO A 167 (-4.1A) MLI A 161 (-4.5A) None None	1.38A	3ou6D-3fncA: undetectable	3ou6D-3fncA: 18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU7_C_SAMC300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	3fnc	PUTATIVE ACETYLTRANSFERASE (Listeria innocua)	5 / 12	LEU A 89 TYR A 88 TYR A 45 ALA A 72 GLY A 70	EDO A 165 (-4.9A) EDO A 167 (-4.1A) MLI A 161 (-4.5A) None None	1.35A	3ou7C-3fncA: undetectable	3ou7C-3fncA: 18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU7_C_SAMC300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	3fnc	PUTATIVE ACETYLTRANSFERASE (Listeria innocua)	5 / 12	TYR A 45 ALA A 72 GLY A 70 LEU A 102 ALA A 85	MLI A 161 (-4.5A) None None None None	1.30A	3ou7C-3fncA: undetectable	3ou7C-3fncA: 18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU7_C_SAMC300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	3fnc	PUTATIVE ACETYLTRANSFERASE (Listeria innocua)	5 / 12	TYR A 88 TYR A 45 ALA A 72 GLY A 70 LEU A 102	EDO A 167 (-4.1A) MLI A 161 (-4.5A) None None None	1.23A	3ou7C-3fncA: undetectable	3ou7C-3fncA: 18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU7_D_SAMD300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	3fnc	PUTATIVE ACETYLTRANSFERASE (Listeria innocua)	5 / 12	TYR A 88 TYR A 45 ALA A 72 GLY A 70 LEU A 102	EDO A 167 (-4.1A) MLI A 161 (-4.5A) None None None	1.24A	3ou7D-3fncA: undetectable	3ou7D-3fncA: 18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSA_A_X2NA590_1 (CYP51 VARIANT1)	3fnc	PUTATIVE ACETYLTRANSFERASE (Listeria innocua)	5 / 12	ALA A 56 LEU A 84 PHE A 130 PHE A 87 GLY A 99	None None MLI A 162 (-4.7A) None MLI A 162 (-3.4A)	1.19A	5fsaA-3fncA: undetectable	5fsaA-3fncA: 17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MRA_B_DM2B204_1 (SORCIN)	3fnc	PUTATIVE ACETYLTRANSFERASE (Listeria innocua)	4 / 6	TYR A 147 PHE A 40 ASP A 145 GLY A 148	None MLI A 161 (-4.8A) None None	1.18A	5mraA-3fncA: undetectable 5mraB-3fncA: undetectable	5mraA-3fncA: 21.67 5mraB-3fncA: 21.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3D4S_A_TIMA401_2","BETA-2 ADRENERGIC RECEPTOR\/T4-LYSOZYME CHIMERA","3fnc","PUTATIVE ACETYLTRANSFERASE","Listeria innocua",3,"THR A  27;SER A  23;PHE A  40","None;None;MLI A 161 (-4.8A)","0.67A","3d4sA-3fncA:undetectable","3d4sA-3fncA:16.27"],["3OU6_D_SAMD300_0","SAM-DEPENDENT METHYLTRANSFERASE","3fnc","PUTATIVE ACETYLTRANSFERASE","Listeria innocua",5,"LEU A  89;TYR A  88;TYR A  45;ALA A  72;GLY A  70","EDO A 165 (-4.9A);EDO A 167 (-4.1A);MLI A 161 (-4.5A);None;None","1.38A","3ou6D-3fncA:undetectable","3ou6D-3fncA:18.83"],["3OU7_C_SAMC300_0","SAM-DEPENDENT METHYLTRANSFERASE","3fnc","PUTATIVE ACETYLTRANSFERASE","Listeria innocua",5,"LEU A  89;TYR A  88;TYR A  45;ALA A  72;GLY A  70","EDO A 165 (-4.9A);EDO A 167 (-4.1A);MLI A 161 (-4.5A);None;None","1.35A","3ou7C-3fncA:undetectable","3ou7C-3fncA:18.83"],["3OU7_C_SAMC300_0","SAM-DEPENDENT METHYLTRANSFERASE","3fnc","PUTATIVE ACETYLTRANSFERASE","Listeria innocua",5,"TYR A  45;ALA A  72;GLY A  70;LEU A 102;ALA A  85","MLI A 161 (-4.5A);None;None;None;None","1.30A","3ou7C-3fncA:undetectable","3ou7C-3fncA:18.83"],["3OU7_C_SAMC300_0","SAM-DEPENDENT METHYLTRANSFERASE","3fnc","PUTATIVE ACETYLTRANSFERASE","Listeria innocua",5,"TYR A  88;TYR A  45;ALA A  72;GLY A  70;LEU A 102","EDO A 167 (-4.1A);MLI A 161 (-4.5A);None;None;None","1.23A","3ou7C-3fncA:undetectable","3ou7C-3fncA:18.83"],["3OU7_D_SAMD300_0","SAM-DEPENDENT METHYLTRANSFERASE","3fnc","PUTATIVE ACETYLTRANSFERASE","Listeria innocua",5,"TYR A  88;TYR A  45;ALA A  72;GLY A  70;LEU A 102","EDO A 167 (-4.1A);MLI A 161 (-4.5A);None;None;None","1.24A","3ou7D-3fncA:undetectable","3ou7D-3fncA:18.83"],["5FSA_A_X2NA590_1","CYP51 VARIANT1","3fnc","PUTATIVE ACETYLTRANSFERASE","Listeria innocua",5,"ALA A  56;LEU A  84;PHE A 130;PHE A  87;GLY A  99","None;None;MLI A 162 (-4.7A);None;MLI A 162 (-3.4A)","1.19A","5fsaA-3fncA:undetectable","5fsaA-3fncA:17.76"],["5MRA_B_DM2B204_1","SORCIN;SORCIN","3fnc","PUTATIVE ACETYLTRANSFERASE","Listeria innocua",4,"TYR A 147;PHE A  40;ASP A 145;GLY A 148","None;MLI A 161 (-4.8A);None;None","1.18A","5mraA-3fncA:undetectable;5mraB-3fncA:undetectable","5mraA-3fncA:21.67;5mraB-3fncA:21.67"]]