SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fnt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3fnt HAP PROTEIN
(Plasmodium
falciparum) 		4 / 5 LEU A 188
LEU A 128
SER A  75
LEU A  73
 None
 1.01A 1a4lC-3fntA:
undetectable		 1a4lC-3fntA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3fnt HAP PROTEIN
(Plasmodium
falciparum) 		4 / 8 TYR A 313
THR A 311
GLY A 302
VAL A 212
 None
 0.89A 2a1oA-3fntA:
undetectable		 2a1oA-3fntA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3fnt HAP PROTEIN
(Plasmodium
falciparum) 		4 / 4 PHE A  31
TYR A 136
ILE A 213
LEU A 214
 None
 1.43A 3sudA-3fntA:
undetectable		 3sudA-3fntA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 3fnt HAP PROTEIN
(Plasmodium
falciparum) 		4 / 7 ASP A 290
THR A 225
PRO A 288
THR A 222
 None
 1.26A 5b6iA-3fntA:
undetectable		 5b6iA-3fntA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3fnt HAP PROTEIN
(Plasmodium
falciparum) 		4 / 5 VAL A 197
VAL A 205
GLY A 201
PHE A 227
 None
 0.79A 5d4nA-3fntA:
undetectable
5d4nC-3fntA:
undetectable		 5d4nA-3fntA:
14.46
5d4nC-3fntA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 3fnt HAP PROTEIN
(Plasmodium
falciparum) 		5 / 11 PHE A 310
ILE A 153
LEU A  30
LEU A 214
ALA A  34
 None
 1.32A 5fctA-3fntA:
undetectable		 5fctA-3fntA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 3fnt HAP PROTEIN
(Plasmodium
falciparum) 		5 / 12 PHE A 310
ILE A 153
LEU A  30
LEU A 214
ALA A  34
 None
 1.33A 5fctB-3fntA:
undetectable		 5fctB-3fntA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 3fnt HAP PROTEIN
(Plasmodium
falciparum) 		3 / 3 ASP A  68
SER A  58
TYR A  64
 None
 0.80A 5glmA-3fntA:
undetectable		 5glmA-3fntA:
22.14