SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fo5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		4 / 6 LEU A 443
ARG A 414
TYR A 547
VAL A 432
 None
 0.88A 1db1A-3fo5A:
undetectable		 1db1A-3fo5A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		3 / 3 ARG A 523
GLY A 553
PRO A 552
 None
None
GOL  A 595 ( 4.8A)
 0.63A 2hreD-3fo5A:
undetectable		 2hreD-3fo5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		4 / 8 ALA A 492
ILE A 471
ILE A 490
HIS A 516
 None
 0.91A 2zm8A-3fo5A:
undetectable		 2zm8A-3fo5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		4 / 8 ALA A 492
ILE A 471
ILE A 490
HIS A 516
 None
 0.92A 2zmaA-3fo5A:
undetectable		 2zmaA-3fo5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 12 ARG A 449
VAL A 544
LEU A 395
GLY A 531
LEU A 443
 1PE  A   2 (-2.8A)
None
None
None
None
 0.98A 3n8zB-3fo5A:
undetectable		 3n8zB-3fo5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		4 / 8 VAL A 544
TYR A 546
LEU A 415
TYR A 570
 None
1PE  A   2 (-4.0A)
None
None
 1.11A 3v81A-3fo5A:
undetectable		 3v81A-3fo5A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		4 / 8 GLU A 521
ARG A 523
GLY A 525
ARG A 524
 None
 1.06A 4fgzA-3fo5A:
undetectable
4fgzB-3fo5A:
undetectable		 4fgzA-3fo5A:
22.52
4fgzB-3fo5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 12 TYR A 546
THR A 527
THR A 551
ALA A 550
TRP A 404
 1PE  A   2 (-4.0A)
1PE  A   2 ( 3.8A)
1PE  A   2 (-4.5A)
GOL  A 595 (-4.3A)
None
 1.24A 4u15B-3fo5A:
undetectable		 4u15B-3fo5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 9 ARG A 447
LEU A 508
ILE A 506
SER A 493
ALA A 470
 None
1PE  A   2 (-4.7A)
None
None
None
 1.45A 4z69A-3fo5A:
undetectable		 4z69A-3fo5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 10 ARG A 447
LEU A 508
ILE A 506
SER A 493
ALA A 470
 None
1PE  A   2 (-4.7A)
None
None
None
 1.42A 4z69I-3fo5A:
undetectable		 4z69I-3fo5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		4 / 6 ALA A 550
SER A 425
SER A 394
PRO A 374
 GOL  A 595 (-4.3A)
None
None
None
 1.14A 5c6pA-3fo5A:
undetectable		 5c6pA-3fo5A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EDL_A_VIBA201_1
(PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 12 TYR A 456
ILE A 490
SER A 530
TYR A 546
ARG A 449
 None
None
1PE  A   2 ( 4.3A)
1PE  A   2 (-4.0A)
1PE  A   2 (-2.8A)
 1.09A 5edlA-3fo5A:
undetectable		 5edlA-3fo5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EDL_A_VIBA201_1
(PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 12 TYR A 456
VAL A 489
ILE A 490
TYR A 546
ARG A 449
 None
None
None
1PE  A   2 (-4.0A)
1PE  A   2 (-2.8A)
 1.24A 5edlA-3fo5A:
undetectable		 5edlA-3fo5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		4 / 7 GLY A 531
ALA A 492
PHE A 532
ASN A 548
 None
None
None
GOL  A 595 (-4.0A)
 0.89A 5mvsA-3fo5A:
undetectable		 5mvsA-3fo5A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		4 / 8 GLY A 531
ALA A 492
PHE A 532
ASN A 548
 None
None
None
GOL  A 595 (-4.0A)
 0.88A 5mvsB-3fo5A:
undetectable		 5mvsB-3fo5A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		3 / 3 ALA A 439
GLN A 540
THR A 542
 None
 0.60A 5n0oA-3fo5A:
undetectable		 5n0oA-3fo5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		3 / 3 GLU A 577
HIS A 433
VAL A 432
 None
 0.78A 5trqB-3fo5A:
undetectable		 5trqB-3fo5A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		4 / 8 VAL A 413
TYR A 570
HIS A 427
CYH A 533
 None
 1.20A 6gneB-3fo5A:
undetectable		 6gneB-3fo5A:
18.73