SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3foc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.36A 1fkfA-3focA:
undetectable
1fkfA-3focA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.36A 1fkjA-3focA:
undetectable
1fkjA-3focA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 6 PRO A 211
ASP A 145
ASP A 143
TYR A 104
None
1.39A 1hpkA-3focA:
undetectable
1hpkA-3focA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.28A 1tcoC-3focA:
undetectable
1tcoC-3focA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.21A 1yatA-3focA:
undetectable
1yatA-3focA:
14.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
7 / 12 TYR A  73
THR A  74
GLY A  75
GLY A  77
THR A 110
GLU A 113
GLN A 198
None
0.77A 2akeA-3focA:
46.5
2akeA-3focA:
43.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
8 / 12 TYR A  73
THR A  74
GLY A  75
GLY A  77
THR A 110
GLU A 113
ILE A 269
PHE A 279
None
0.55A 2akeA-3focA:
46.5
2akeA-3focA:
43.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
6 / 12 TYR A  73
THR A  74
GLY A  75
ILE A 269
GLN A 275
PHE A 279
None
1.00A 2akeA-3focA:
46.5
2akeA-3focA:
43.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
7 / 12 TYR A  73
THR A  74
GLY A  75
GLY A  77
GLN A 108
THR A 110
GLN A 198
None
0.70A 2azxA-3focA:
46.2
2azxA-3focA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
9 / 12 TYR A  73
THR A  74
GLY A  75
GLY A  77
GLN A 108
THR A 110
GLU A 113
ILE A 269
PHE A 279
None
0.49A 2azxA-3focA:
46.2
2azxA-3focA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
6 / 12 TYR A  73
THR A  74
GLY A  75
ILE A 269
GLN A 275
PHE A 279
None
1.01A 2azxA-3focA:
46.2
2azxA-3focA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
7 / 8 LEU A  88
ILE A  92
PHE A 368
LEU A 403
ILE A 404
HIS A 407
ARG A 410
None
0.86A 2azxA-3focA:
46.2
2azxA-3focA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
6 / 12 TYR A  73
GLY A  75
GLY A  77
GLN A 108
THR A 110
GLN A 198
None
0.64A 2azxB-3focA:
45.9
2azxB-3focA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
9 / 12 TYR A  73
THR A  74
GLY A  75
GLY A  77
GLN A 108
THR A 110
GLU A 113
ILE A 269
PHE A 279
None
0.54A 2azxB-3focA:
45.9
2azxB-3focA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
6 / 12 TYR A  73
THR A  74
GLY A  75
ILE A 269
GLN A 275
PHE A 279
None
1.02A 2azxB-3focA:
45.9
2azxB-3focA:
40.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 8 TYR A 382
ASP A 359
SER A 340
HIS A 349
None
1.07A 2bteA-3focA:
4.0
2bteA-3focA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 8 TYR A 382
ASP A 359
SER A 340
HIS A 349
None
1.02A 2bteD-3focA:
5.3
2bteD-3focA:
19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 TYR A  73
GLY A  75
GLY A  77
GLN A 108
GLN A 198
None
1.49A 2dr2A-3focA:
46.4
2dr2A-3focA:
43.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
7 / 11 TYR A  73
GLY A  75
GLY A  77
GLN A 108
THR A 110
GLU A 113
GLN A 198
None
0.74A 2dr2A-3focA:
46.4
2dr2A-3focA:
43.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
8 / 11 TYR A  73
GLY A  75
GLY A  77
GLN A 108
THR A 110
GLU A 113
ILE A 269
PHE A 279
None
0.56A 2dr2A-3focA:
46.4
2dr2A-3focA:
43.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 TYR A  73
GLY A  75
ILE A 269
GLN A 275
PHE A 279
None
1.16A 2dr2A-3focA:
46.4
2dr2A-3focA:
43.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 10 GLY A  86
LEU A  88
LEU A  89
ILE A  92
LEU A 403
None
1.01A 2f8dA-3focA:
undetectable
2f8dA-3focA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 10 GLY A  86
LEU A  88
LEU A  89
ILE A  92
LEU A 403
None
1.02A 2f8dB-3focA:
undetectable
2f8dB-3focA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.33A 2fkeA-3focA:
undetectable
2fkeA-3focA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
6 / 11 PHE A 256
ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.45A 2vn1A-3focA:
undetectable
2vn1A-3focA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 10 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.25A 2vn1B-3focA:
undetectable
2vn1B-3focA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 7 GLY A  86
ILE A  92
MET A  45
LEU A 302
None
0.90A 2xrhA-3focA:
undetectable
2xrhA-3focA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 6 ARG A 161
GLN A 108
PHE A 148
LEU A 428
None
1.18A 3ablP-3focA:
undetectable
3ablW-3focA:
undetectable
3ablP-3focA:
19.12
3ablW-3focA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 10 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.27A 3ihzA-3focA:
undetectable
3ihzA-3focA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 7 PHE A 181
GLY A 182
PHE A 183
PHE A 194
None
0.93A 3ko0D-3focA:
undetectable
3ko0E-3focA:
undetectable
3ko0D-3focA:
12.28
3ko0E-3focA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 7 PHE A 194
PHE A 181
GLY A 182
PHE A 183
None
0.91A 3ko0M-3focA:
0.0
3ko0P-3focA:
undetectable
3ko0M-3focA:
12.28
3ko0P-3focA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 8 PHE A 181
GLY A 182
PHE A 183
PHE A 194
None
0.94A 3ko0O-3focA:
undetectable
3ko0Q-3focA:
undetectable
3ko0O-3focA:
12.28
3ko0Q-3focA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.36A 3o5rA-3focA:
undetectable
3o5rA-3focA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 10 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.18A 3uf8A-3focA:
undetectable
3uf8A-3focA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 10 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.19A 3uqaA-3focA:
undetectable
3uqaA-3focA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
3 / 3 LYS A 370
ARG A 410
LEU A 403
None
1.33A 3v4tE-3focA:
undetectable
3v4tE-3focA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.24A 3vawA-3focA:
undetectable
3vawA-3focA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 7 GLY A  77
THR A 110
ILE A 109
THR A  94
None
0.92A 4acaC-3focA:
2.5
4acaC-3focA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 10 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.41A 4dz3A-3focA:
undetectable
4dz3A-3focA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 10 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.21A 4dz3B-3focA:
undetectable
4dz3B-3focA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 12 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.24A 5b8iC-3focA:
undetectable
5b8iC-3focA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.21A 5huaA-3focA:
undetectable
5huaA-3focA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.23A 5hw8D-3focA:
undetectable
5hw8D-3focA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 11 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.17A 5hwcA-3focA:
undetectable
5hwcA-3focA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 8 LEU A  97
PHE A  34
GLU A  35
ILE A  26
None
0.90A 5mzjA-3focA:
undetectable
5mzjA-3focA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
3 / 3 LEU A 323
ILE A 404
TYR A 364
None
0.67A 5uunB-3focA:
undetectable
5uunB-3focA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 6 ARG A 161
GLN A 108
PHE A 148
LEU A 428
None
1.12A 5z84P-3focA:
undetectable
5z84W-3focA:
undetectable
5z84P-3focA:
19.12
5z84W-3focA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 6 ARG A 161
GLN A 108
PHE A 148
LEU A 428
None
1.13A 5z85P-3focA:
undetectable
5z85W-3focA:
undetectable
5z85P-3focA:
19.12
5z85W-3focA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 6 ARG A 161
GLN A 108
PHE A 148
LEU A 428
None
1.08A 5z86C-3focA:
undetectable
5z86J-3focA:
undetectable
5z86C-3focA:
19.12
5z86J-3focA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 6 ARG A 161
GLN A 108
PHE A 148
LEU A 428
None
1.08A 5zcpC-3focA:
undetectable
5zcpJ-3focA:
undetectable
5zcpC-3focA:
19.12
5zcpJ-3focA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
4 / 6 ARG A 161
GLN A 108
PHE A 148
LEU A 428
None
1.12A 5zcpP-3focA:
undetectable
5zcpW-3focA:
undetectable
5zcpP-3focA:
19.12
5zcpW-3focA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 12 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.22A 6mkeA-3focA:
undetectable
6mkeD-3focA:
undetectable
6mkeA-3focA:
11.42
6mkeD-3focA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis)
5 / 10 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.24A 6mkeD-3focA:
undetectable
6mkeD-3focA:
11.42